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New Post Hoc Analyses Examined the Effects of Neupro® (Rotigotine Transdermal System) on Daytime Functioning, Daytime Symptoms, Pain and Mood in Restless Legs Syndrome
Date:6/10/2011

verity of mood disturbance due to RLS symptoms (p<0.0001). Significant improvement with rotigotine transdermal versus placebo (from baseline to end of maintenance) was also seen in the Self-rating Depression Scale (SDS-Index), i.e. patient reporting of moderate to definite severe depression (p<0.0001).

Notes to Editors

About Restless Legs Syndrome

Restless Legs Syndrome (RLS) is a neurological disorder characterized by an uncontrollable urge to move the legs during periods of inactivity and rest. These urges are usually accompanied by uncomfortable or unpleasant sensations in the legs.  Prevalence in the general population is between 3% and 10% and treatment is needed only in the moderate to severe form of the disorder. Dopaminergic treatment is the first choice in idiopathic restless legs syndrome.

About Neupro® in European Union

Neupro® is approved in the European Union for the symptomatic treatment of moderate to severe idiopathic restless legs syndrome in adults. Neupro® (rotigotine) is also approved in the European Union for the treatment of the signs and symptoms of early-stage idiopathic Parkinson's disease, as monotherapy (i.e. without levodopa) or in combination with levodopa, i.e. over the course of the disease, through to late stages when the effect of levodopa wears off or becomes inconsistent and fluctuations of the therapeutic effect occurs.

Neupro® in Europe Important Safety Information

Neupro® is contraindicated in case of hypersensitivity to the active substance or to any of its excipients, and in case of magnetic resonance imaging (MRI) or cardioversion. Neupro® should be removed if the patient has to undergo MRI or cardioversion.

It is recommended to monitor blood pressure, especially at the beginning of treatment, due to the general risk of orthostatic hypotension associated with dopaminergic therapy.

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