Navigation Links
New Phase 2 Data Published in New England Journal of Medicine Show Bardoxolone Methyl Sustained Improvement in Measure of Kidney Function (eGFR) Over 52 Weeks in Patients With Moderate to Severe Chronic Kidney Disease and Type 2 Diabetes
Date:6/24/2011

IRVING, Texas and ABBOTT PARK, Ill., June 24, 2011 /PRNewswire/ -- New Phase 2 clinical trial data published online today in The New England Journal of Medicine show that patients with moderate to severe chronic kidney disease and type 2 diabetes receiving bardoxolone methyl for 52 weeks experienced a sustained improvement in kidney function throughout the treatment period, as measured by estimated glomerular filtration rate (eGFR). The data were also presented today in a Late-Breaking Clinical Trials session at the 2011 European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Congress in Prague, Czech Republic.

The Phase 2 dose-finding clinical trial, known as the BEAM study, showed that in patients with moderate to severe chronic kidney disease – defined by an eGFR of 20 to 45 mL/min/1.73m2 – and type 2 diabetes, eGFR at 52 weeks was significantly improved with bardoxolone methyl treatment by up to 10.5 mL/min/1.73m2 in patients receiving 75 mg (p<0.001).

"The published data for bardoxolone methyl suggest that it may have potential to delay kidney disease progression in patients with compromised kidney function," said Dr. David Warnock of the University of Alabama at Birmingham, who presented the findings at the ERA-EDTA session and is the senior author of the article.  "Further study to learn more about the clinical benefits of this drug candidate is warranted."

The multi-center, double-blind, placebo-controlled trial enrolled 227 patients who were randomly assigned to receive placebo, 25, 75 or 150 mg of bardoxolone methyl orally, once daily for 52 weeks.

Specifically, the 52-week data showed:

  • At 52 weeks, patients receiving each of the three tested doses of bardoxolone methyl experienced a statistically significant improvement in eGFR, an important measure of kidney function. Increases were 5.8, 10.5 and 9.3 mL/min/1.73m2 for the 25, 75
    '/>"/>

SOURCE Abbott
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
3. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... YORK , May 20, 2013 /PRNewswire-iReach/ -- It is ... than one third being overweight or obese gyms and supplement ... the time the condition is primarily related to dietary issues ... can be the result of a glandular problem or even ... One common vitamin deficiency is a lack of ...
(Date:5/20/2013)... May 20, 2013  Upsher-Smith Laboratories, Inc., a ... new treatments for diseases of the central nervous ... designed website, upsher-smith.com . The new site ... part of the company,s mission statement – Advancing ... centers around people with a story to tell, ...
(Date:5/20/2013)...  Hill-Rom Holdings, Inc. (NYSE: HRC ) ... the 38 th Annual Deutsche Bank Health Care ... 30, 2013, at 1:30 p.m. EDT. (Logo: ... to listen to the live discussion via the internet ... at http://www.media-server.com/m/p/f7bj3q84 . A recorded replay of the ...
Breaking Medicine Technology:USB12Shots.com Discusses the Possibility of B12 Shots for Weight Loss 2Upsher-Smith Introduces Newly Redesigned Corporate Website 2
... , , Coalition ... Hepatitis and support CDC research and programs , ... the Institute of Medicine (IOM) report on viral hepatitis, the ... Disease Control and Prevention), in partnership with CDC,s Division of ...
... , , , , JERUSALEM, Jan. 11 ... Alert for TNT/PETN/RDX/NITRATE Explosive Identifier is actually a General Screening ... TNT,PETN,RDX and Nitrates but with the 3 ampoules it contains, ... which makes it a General Screening Explosive Identifier.. , Ampoule ...
Cached Medicine Technology:CDC Foundation Launches Viral Hepatitis Action Coalition 2International Drug & Explosives Detection Firm IDenta Corp Announces that the TNT/PETN/RDX/NITRATE Test Kit can be used as a General Screening Explosive Identifier 2International Drug & Explosives Detection Firm IDenta Corp Announces that the TNT/PETN/RDX/NITRATE Test Kit can be used as a General Screening Explosive Identifier 3
(Date:5/21/2013)... Albuquerque, New Mexico (PRWEB) May 21, 2013 ... Practical Perspective for Caregivers ” has over 50 years ... years was the process of losing both her mom ... years has been serving as a volunteer with the ... experiences have given her an understanding and insight into ...
(Date:5/21/2013)... Canadian-based FundRazr has 25 million reasons why ... has accumulated a list of our 25 Most Notable ... this week. Among them is the DC Entertainment and ... from video gamers, on-going legal fees support for the ... Tiger Woods sending underserved kids to school, lifesaving health ...
(Date:5/21/2013)... HealthDay Reporter , , MONDAY, May 20 (HealthDay News) -- ... critically ill patients who have been placed on ventilators, ... according to a new study. Intensive care unit ... choice whenever they liked enjoyed a 36 percent reduction ... music, researchers found. The ICU patients who were ...
(Date:5/21/2013)... Amy Norton HealthDay Reporter , , MONDAY, May 20 ... has become the norm for prostate cancer in the United ... -- at least for some men, a new study suggests. ... who had radiation therapy after prostate cancer surgery, the newer ... advantage over the conventional version. Men who received ...
(Date:5/21/2013)... May 21, 2013 Dr. James C. ... Director of the Sarcoma Division of the John Theurer ... Jersey has been named one of the top 13 ... Week. Dr. Wittig is one of approximately 125 ... list was created by surveying thought leaders in the ...
Breaking Medicine News(10 mins):Health News:International Book Release on Alzheimer’s Care-giving by Barbara Michels “The Alzheimer’s Journey…A Practical Perspective for Caregivers 2Health News:International Book Release on Alzheimer’s Care-giving by Barbara Michels “The Alzheimer’s Journey…A Practical Perspective for Caregivers 3Health News:International Book Release on Alzheimer’s Care-giving by Barbara Michels “The Alzheimer’s Journey…A Practical Perspective for Caregivers 4Health News:Favorite Music May Ease Anxiety in ICU Patients 2Health News:Favorite Music May Ease Anxiety in ICU Patients 3Health News:Newer, Pricier Prostate Cancer Radiation No Better Than Old: Study 2Health News:Newer, Pricier Prostate Cancer Radiation No Better Than Old: Study 3Health News:Newer, Pricier Prostate Cancer Radiation No Better Than Old: Study 4Health News:James C. Wittig, MD, Selected as one of America's Top 13 Orthopaedic Oncologists 2Health News:James C. Wittig, MD, Selected as one of America's Top 13 Orthopaedic Oncologists 3
... of Public Health reported that most of the flu shot ... to the department, 94% of the state's total order has ... 24. Over 1.7 million vaccines will be stocked that includes ... Centers for Disease Control and Prevention revealed that this flu ...
... The World Health Organization (WHO), on Friday, had initiated the ... prevent infections associated //with Health care practices. WHO said that ... costs but also will save lives. ,It is ... by the infections caused by the hospitals, which are mainly ...
... are more likely to develop certain types of cancer ... // ,Grace LeMasters and colleagues at the ... fire fighters from 32 previously published scientific studies to ... of their profession, reported science portal EurekAlert. ...
... recent study revealed that consuming just two cups of green ... Texas in collaboration with their counterparts in the UK carried ... online edition of the Journal of Allergy and Clinical Immunology. ... (EGCG) present in green tea has the ability to block ...
... disease are alarming. According to a news release by McGill ... Canada and 8,500 deaths from the disease are expected every ... deaths, as reported by the Centers for Disease Control and ... and 16,000 deaths. ,However, here is some good ...
... the eyes can diagnose cerebral malaria in children, according ... complication where the Plasmodium falciparum parasite infects capillaries that ... to detect as patients can be unconscious and have ... ratio in cerebral malaria is 25-50 percent, reported science ...
Cached Medicine News:Health News:The Anti-HIV Properties Of Green Tea Uncovered 2
Micro dressing forceps....
... Leica M520 OH3 is a ... optical performance available on the ... unique stand. The Leica M520 ... the greatest range of movement ...
Advanced operating microscope with zoom and variable focus up to 500 mm....
DUALSWITCH-SHUNTSYSTEM for L-P-Derivation...
Medicine Products: