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New PLATO Sub-Analysis of CABG Patients Presented at ACC
Date:3/16/2010

onary Artery Bypass Grafting)

CABG surgery is advised for certain ACS patients, including those who are not candidates for percutaneous coronary intervention (PCI). It is not always known which ACS patients will be advised for CABG surgery at the time of initiating oral antiplatelet therapy.(3) These patients have significant narrowing and blockages of the heart arteries (coronary artery disease).(4) CABG is a type of heart surgery that reroutes, or "bypasses," blood around clogged arteries to improve blood flow and oxygen to the heart.(5)

About PLATO CABG analysis

In the PLATO study, a double-dummy, double-blind randomized trial comparing ticagrelor plus aspirin with clopidogrel plus aspirin in patients with ACS, 1899 patients underwent CABG during the trial.(1) The trial recommended administration of ticagrelor/placebo-clopidogrel to be withheld for 24-72 hours and clopidogrel/placebo-ticagrelor for 5 days prior to CABG surgery. In the exploratory analysis, 1261 patients received study-drug up to seven days prior to CABG surgery.(1) The analysis counted events occurring from after the CABG procedure until the end of the study.(1)


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