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New PLATO Sub-Analysis of CABG Patients Presented at ACC
Date:3/16/2010

eatment:

  • Total mortality was reduced by 51% (RRR; p<0.01) with ticagrelor (4.6% of 632) compared to clopidogrel (9.2% of 629)(1)
  • CV death was reduced by 48% (RRR; p<0.01) with ticagrelor (4.0% of 632) compared to clopidogrel (7.5% of 629)(1)
  • Rate of the primary endpoint (composite of CV death, myocardial infarction, or stroke) from the time of CABG was 10.5% (66/632) with ticagrelor and 12.6% (79/629) with clopidogrel (HR 0.84; CI 0.60-1.16, p=0.29)(1)

Additionally, there was no significant difference in CABG-related major bleeding for ticagrelor compared to clopidogrel,(1) according to both the PLATO and TIMI bleeding criteria respectively (81% for ticagrelor vs. 80% for clopidogrel, and 59% for ticagrelor vs. 58% for clopidogrel for PLATO-defined and TIMI-defined, respectively).

"These treatment comparisons were consistent with the effects seen in the overall PLATO trial," said Dr. Claes Held.(1,2)

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