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New PLATO Sub-Analysis of CABG Patients Presented at ACC
Date:3/16/2010

ATLANTA, March 16 /PRNewswire-FirstCall/ -- AstraZeneca (NYSE: AZN) today announced results of a new analysis of the PLATO (A Study of PLATelet Inhibition and Patient Outcomes) study which showed there were fewer deaths in patients with acute coronary syndromes (ACS) who took the investigational oral antiplatelet ticagrelor (BRILINTA™/BRILIQUE™) within seven days prior to having heart bypass surgery (coronary artery bypass graft, CABG) compared to those who took clopidogrel.(1) These data were presented today at the American College of Cardiology (ACC) meeting in Atlanta, Georgia.

"The CABG sub-analysis represents current clinical management of patients with ACS,"(1) said Dr. Claes Held, PhD, Associate Professor of Cardiology at the Uppsala Clinical Research Center and Department of Cardiology, and the sub-study's lead researcher.  "The effects of ticagrelor compared to clopidogrel showed a reduction of total mortality by 51% and CV death by 48%."(1)

This analysis included 1261 patients who were on study medication up to seven days prior to stopping study medication due to the need for urgent CABG surgery at any time after their ACS event.(1) The patients randomized to ticagrelor had a significantly lower rate of total and CV death than those randomized to clopidogrel tr
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SOURCE AstraZeneca
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