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New Oral Anticoagulants Markets
Date:3/25/2013

11.9 Eli Lilly & Co 222
11.9.1 Effient (Daiichi Sankyo) 222
11.9.2 General Risk of Bleeding 223
11.9.3 Coronary Artery By-Pass Graft Surgery-Related Bleeding 224
11.9.4 Discontinuation of Effient 224
11.9.5 Thrombotic Thrombocytopenic Purpura 224
11.9.6 Hypersensitivity Including Angiodema 225
11.9.7 Clinical Studies 225
11.10 Genentech, Inc. 227
11.10.1 Activase (Altepase) 227
11.11 GlaxoSmithKline PLC 227
11.11.1 Fondaparinux 228
11.12 Medicure, Inc. 228
11.12.1 Aggrastat 228
11.13 Merck & Co., Inc. 229
11.13.1 SCH 5303348 229
11.14 Novartis AG 229
11.14.1 Elinogrel 229
11.15 Ortho-McNeil Pharmaceutical, Inc. 229
11.15.1 Rivaroxaban (Xarelto) 230
11.16 Pfizer, Inc. 230
11.16.1 Eliquis (Apixaban) 230
11.17 Pharmion, LLC 230
11.17.1 Tinzaparin (Innohep) 231
11.18 Portola Pharmaceuticals, Inc. 231
11.19 Sanofi 232
11.19.1 Lovenox (Enoxaparin) 232
11.19.2 Idrabiotaparinux 233
11.20 The Medicines Company 233
11.20.1 Argatroban 233
11.20.2 Angiomax (Bivalirudin) 234

Appendix 1: Innovations in Cardiac Rhythm Management with New Anticoagulants 235
Appendix 1.1: Dual Antiplatelet Therapy 236
Appendix 1.2: Direct Thrombin Inhibitors 236
Appendix 1.3: Factor Xa Inhibitors 238
Appendix 1.4: Comparing the Trials 240
Appendix 1.5: Interventions Targeting the Left Atrial Appendage 241
Appendix 2: Oral Contraceptives and the Risk of Venous Thromboembolism 244
Appendix 2.1: Hormonal Effects on Venus Thromboembolism 244
Appendix 2.2: Assessing Venous Thromboembolism Risks of Oral Contraceptives 245
Appendix 2.3: Recent Research 245

INDEX OF FIGURES

Figure 2.1: Almost 100 Years of Anticoagulation Therapy 17
Figure 2.2: Site of Action of New Anticoagulants 22
Figure 3.1: Pathway of Dabigatran Action 36
Figure 3.2: Sites of Action of Dabigatran and Rivaroxaban 45
Figure 3.3: Time to Firs
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