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New Oral Anticoagulants Markets
Date:3/25/2013

nical Efficacy 44
3.2.16.7 Strengths of Dabigatran in Controlling Bleeding 44
3.2.17 Comparison of Dabigatran and Rivaroxaban in Sites of Action 45
3.3 Rivaroxaban (Xarelto) 45
3.3.1 Dosage and Administration 46
3.3.2 Risk of Stroke after Discontinuation in Non-Valvular Atrial Fibrillation 47
3.3.3 Risk of Bleeding 47
3.3.4 Bleeding Events in ROCKET AF Trial 48
3.3.5 Bleeding Events in RECORD Trial 48
3.3.6 Overdosage 49
3.3.7 Mechanism of Action 50
3.3.8 Comparable Efficacy of Rivaroxaban 50
3.3.9 Prophylaxis of Deep Vein Thrombosis 52
3.4 Eliquis (Apixaban) 53
3.4.1 AVERROES Results 56
3.5 Edoxaban 58
3.6 Betrixaban 59
3.7 Pipeline Agents 63
3.8 Comparison of Oral Anticoagulants 66
3.9 Heparins 68
3.10 Dalteparin (Fragmin) 70
3.11 Enoxaparin (Lovenox) 70
3.11.1 Indications and Usage 70
3.11.2 Percutaneous Coronary Revascularization Procedures 71
3.11.3 Use of Lovenox with Concomitant Medical Conditions 71
3.11.3.1 Thrombocytopenia 71
3.11.3.2 Interchangeability with Other Heparins 72
3.11.3.3 Pregnant Women with Mechanical Prosthetic Heart Valves 72
3.11.3.4 Laboratory Tests 72
3.11.3.5 Pharmacodynamics 72
3.11.3.6 Pharmacokinetics 72
3.12 Fondaparinux (Arixtra) 73
3.13 Tinzaparin (Innohep) 74
3.14 Semuloparin Sodium (AVE5026) 75
3.15 Idrabiotaparinux 75
3.16 Otamixaban 75
3.17 RB006 75
3.18 Reversal Agents and Antidotes 76
3.18.1 Vitamin K 78
3.18.2 Recombinant Factor VIIa 78
3.18.3 Prothrombin Complex Concentrates 80

4. A Brief Overview of Antiplatelets 83
4.1 Overview of this Chapter 83
4.1.1 Differences between Antiplatelets and Anticoagulants 84
4.1.2 Need for Antiplatelets 84
4.1.3 Side Effects of Antiplatelets 85
4.1.4 Choosing an Antiplatelet 86
4.1.5 Role of Platelets in Thrombosis 87
4.1.6 Inhibitors of Platelet Adhesion 88
4.1.7 Inhibitors of Platelet Activa
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