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New Oral Anticoagulants Markets
Date:3/25/2013

is Chapter 16
2.1.1 Unmet Medical Needs with Existing Anticoagulants 17
2.1.2 Pharmacology of Injectable Anticoagulants 18
2.1.3 Marketed and Registered Drugs for Anticoagulation and Related Disorders 19
2.2 Oral Anticoagulants 21
2.2.1 Potential Limitations of New Oral Anticoagulants 23
2.2.2 Desired Attributes of Anticoagulants 24
2.2.3 Comparison of New Anticoagulants 24
2.2.4 Bleed Rates of New Anticoagulants 27

3. Selected Oral Anticoagulants 30
3.1 Warfarin 30
3.1.1 Warfarin's Place in Clinical Therapy 31
3.1.2 Drug Interaction with Warfarin 31
3.1.3 Warfarin's Interactions with Food 32
3.1.4 Interactions of Warfarin with Dietary Vitamin K 34
3.2 Dabigatran (Pradaxa) 36
3.2.1 Use of Dabigatran in Particular Situations 38
3.2.2 Measuring the Anticoagulant Effect of Dabigatran 38
3.2.3 Activated Partial Thromboplastin Time (aPTT) 38
3.2.4 Thrombin Time (TT) and Hemoclot 39
3.2.5 Ecarin Clotting Time (ECT) 39
3.2.6 Prothrombin Time (PT) and INR 39
3.2.7 Measures for Overdose 40
3.2.8 Management of Bleeding Complications 40
3.2.9 For Patients Undergoing Surgical Intervention 40
3.2.10 For Dental Interventions 40
3.2.11 For Spinal Anesthesia/Epidural Anesthesia/Lumbar Puncture 41
3.2.12 For Patients with Acute Coronary Syndrome (ACS) 41
3.2.13 Cardioversion in Dabigatran Treated Patients 41
3.2.14 For Patients with Stroke 41
3.2.15 Dabigatran after Ischemic Stroke 41
3.2.16 Strengths and Weaknesses of Dabigatran 42
3.2.16.1 Strengths of Dabigatran in Metabolism, Pharmacokinetics and
Pharmacodynamics 42
3.2.16.2 Weaknesses of Dabigatran in Metabolism, Pharmacokinetics and
Pharmacodynamics 43
3.2.16.3 Strengths of Dabigatran in Laboratory Monitoring 43
3.2.16.4 Weaknesses of Dabigatran in Laboratory Monitoring 43
3.2.16.5 Strengths of Dabigatran in Clinical Efficacy 44
3.2.16.6 Weaknesses of Dabigatran in Cli
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