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New Oral Anticoagulants Markets

11.1: Boehringer's Pipeline (84 Products in Development) 218
Figure 11.2: The 3D Structure of Dabigatran in Complex with Thrombin 219
Figure 11.3: Non-CABC-Related TIMI Major or Minor Bleeding Events 223
Figure 11.4: Time to First Event of CV Death, MI or Stroke (TRITON-TIMI 38) 226
Figure A1.1: Transesophageal Echocardiogram Showing Thrombus in the Left Atrial
Appendage 235


Table 2.1: Limitations and Consequences of Vitamin K Antagonists 18
Table 2.2: Pharmacokinetics of Injectable Anticoagulants 18
Table 2.3: Marketed and Registered Drugs for Anticoagulation and Related
Disorders 19
Table 2.4: Desired Attributes of Newly Developed Anticoagulants 24
Table 2.5: Comparison of New Anticoagulants 25
Table 3.1: Examples of Drugs that Interact with Warfarin 32
Table 3.2: Vitamin K Content of Selected Vegetables 33
Table 3.3: Weekly Requirements of Vegetables Based on Age and Gender 34
Table 3.4: Vitamin K Content of Commonly Used Oils 34
Table 3.5: Vitamin K Content in the Oil of Fast and Processed Foods 35
Table 3.6: Vitamin K Content in Nutritional Supplements per 8 OZ 35
Table 3.7: Mean Dabigatran Plasma Concentration and the 25th-75th Percentiles 38
Table 3.8: Discontinuation Rules before Surgical Procedures 40
Table 3.9: Strengths and Weaknesses of Dabigatran Compared with Others 43
Table 3.10: Bleeding Events in ROCKET AF Trial 48
Table 3.11: Bleeding Events in Patients Undergoing Hip or Knee Replacement
Surgeries (RECORD) 49
Table 3.12: Other Adverse Reactions Reported in RECORD 1-3 Studies 50
Table 3.13: Clinical Outcomes of EINSTEIN PE 51
Table 3.14: Primary Composite Endpoint Results in ROCKET AF Study 51
Table 3.15: Key Efficacy Analysis Results from RECORD Trial 53
Table 3.16: Phase III AF Trials 58
Table 3.17: Drugs in Development for Anticoagulation and Related Disorders 63
Table 3.18: Comparison of Oral Antic

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