Navigation Links
New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease
Date:6/2/2009

NF-alpha therapy approved by the FDA for the treatment of moderately to severely active Crohn's disease for the reduction of the signs and symptoms in patients who have an inadequate response to conventional therapy. During the past decade, REMICADE has also become the first and only anti-TNF-alpha therapy approved by the FDA for the treatment of moderately to severely active ulcerative colitis, in patients with an inadequate response to conventional therapy, a related inflammatory bowel disease. REMICADE is also approved for the treatment of pediatric patients with moderately to severely active Crohn's disease who have had an inadequate response to conventional therapies.

The SONIC study was supported by Centocor Ortho Biotech, Inc.

About SONIC

SONIC was a multicenter, Phase 3b, randomized, double-blind, controlled clinical trial designed to compare the efficacy and safety of REMICADE monotherapy, azathioprine monotherapy and combination therapy with the 2 drugs in patients with moderately to severely active Crohn's disease who were naive to immunomodulator and biologic therapy. A total of 508 patients from the U.S., Europe and Israel were enrolled in the study and were randomized into three groups; 170 patients received azathioprine less than or equal to 2.5 mg/kg/day and placebo infusions, 169 patients received REMICADE 5 mg/kg infusions at weeks 0, 2, 6 and every 8 weeks thereafter with placebo capsules and 169 patients received REMICADE 5 mg/kg and azathioprine less than or equal to 2.5 mg/kg/day at week 26. The primary endpoint of SONIC was to assess the induction of steroid-free remission at week 26. Patients completing treatment through week 30, and who, in the opinion of the investigator, may benefit from continued treatment, entered into the study extension beginning at week 30 through week 50.

SONIC previously demonstrated the effect of REMICADE therapy on steroid-free remiss
'/>"/>

SOURCE Centocor Ortho Biotech Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. XTENT Announces Positive Two-Year CUSTOM I and One-Year CUSTOM II Trial Data for Novel Drug-Eluting Stent System
2. Abbott Announces Positive One-Year Results from the Worlds First Clinical Trial of a Fully Bioabsorbable Drug Eluting Coronary Stent
3. Results From One-Year Study Suggest Advair(R) Provides Important Benefits for African American Patients With Asthma
4. Data from One-Year Liraglutide Phase 3 Study Published Online in The Lancet
5. New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease
6. New Findings Show Efficacy of REMICADE(R) Compared With Azathioprine in Treatment of Crohns Disease According to First-of-its Kind Study
7. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
8. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
9. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
10. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
11. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)...   LabStyle Innovations Corp . (OTCQB:DRIO), developer of ... appointment of Professor Richard B. Stone ... Directors. Prof. Stone brings over forty-five ... as an entrepreneur, venture capitalist public, company officer ... He currently serves on the board of directors ...
(Date:1/15/2014)... , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds ... its store . (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ... upgrade and policy support, China,s ... years, with total market size rising from 3.28 billion ...
(Date:1/15/2014)... Foundation today announced it has established a relief fund ... weather that has gripped much of the nation. AARP and ... to support these emergency relief efforts AARP and AARP Foundation ... up to $500,000 in aid. The matching program will be ...
Breaking Medicine Technology:LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
... 9, 2011 Reportlinker.com announces that a ... its catalogue: Medical Equipment ... - Q2 2011 ... Deals Analysis: M&A and Investment Trends - ...
... August 9, 2011 , " Two ... Their Transition Schedule   and   Identify Critical Milestones   and ... , a pioneer in providing eLearning solutions to more than 1,300 ... Years and Counting", as well as updates to its eBook, ...
Cached Medicine Technology:Medical Equipment Quarterly Deals Analysis: M&A and Investment Trends - Q2 2011 2Medical Equipment Quarterly Deals Analysis: M&A and Investment Trends - Q2 2011 3Medical Equipment Quarterly Deals Analysis: M&A and Investment Trends - Q2 2011 4Medical Equipment Quarterly Deals Analysis: M&A and Investment Trends - Q2 2011 5Medical Equipment Quarterly Deals Analysis: M&A and Investment Trends - Q2 2011 6Medical Equipment Quarterly Deals Analysis: M&A and Investment Trends - Q2 2011 7Medical Equipment Quarterly Deals Analysis: M&A and Investment Trends - Q2 2011 8Medical Equipment Quarterly Deals Analysis: M&A and Investment Trends - Q2 2011 9Medical Equipment Quarterly Deals Analysis: M&A and Investment Trends - Q2 2011 10Medical Equipment Quarterly Deals Analysis: M&A and Investment Trends - Q2 2011 11Medical Equipment Quarterly Deals Analysis: M&A and Investment Trends - Q2 2011 12Elsevier / MC Strategies Introduces Additional Resources to its ICD-10 Roadmap, Helping Healthcare Organizations Prepare for October 2013 2Elsevier / MC Strategies Introduces Additional Resources to its ICD-10 Roadmap, Helping Healthcare Organizations Prepare for October 2013 3
(Date:7/12/2014)... Praeclarus Press is excited to ... new resource for women in need of lactation support. ... away from their children. Today’s mothers receive very clear ... but often feel unsupported when it comes to balancing ... evidence-based insights, and written by Nancy Mohrbacher, an international ...
(Date:7/12/2014)... Maxim Peptide, a website that features ... solely in scientific experiments, is currently celebrating its second ... Maxim Peptide, which was created by the founders of ... updated website that now features a special deals section. ... with fascinating articles about peptide research, including a new ...
(Date:7/11/2014)... 2014 Recently, DressyQuinceanera.com, a well-known wedding ... Dama dresses to its online category. Furthermore, the ... at deeply discounted rates, up to 62% off. , ... equally excellent in terms of quality and style. All ... discounts are also offered for the company’s other items: ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 As ... filed against Johnson & Johnson’s Ethicon Inc. unit ... LLP notes that the Texas Attorney General’s Office ... marketing of surgical mesh products used to treat ... to a report from kens5.com, the probe began ...
(Date:7/11/2014)... HealthDay Reporter THURSDAY, July 10, 2014 (HealthDay ... thought to be cured by immediate and aggressive drug treatment ... AIDS-causing virus in her bloodstream, disappointed federal officials announced Thursday ... remained virus-free even though she stopped taking HIV medications when ... would open the door to a functional cure for all ...
Breaking Medicine News(10 mins):Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2Health News:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Health News:DressyQuinceanera.com: Beautiful Quinceanera Dama Dresses At Low Prices 2Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 2Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 3Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 4Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 2Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 3
... Challenges to Working FamiliesPITTSBURGH, March 2 ... President Obama,s selection of Gov. Kathleen Sebelius ... and Human Services (HHS).(Logo: http://www.newscom.com/cgi-bin/prnh/20080131/DC12982LOGO )USW ... her nomination is another example of how ...
... Susan G. Komen for the Cure(R) Advocacy Alliance ... to fill a key cabinet post, with the ... the next Secretary of Health and Human Services. ... encouraged that the Obama Administration has moved proactively ...
... EVANSTON, Ill. --- Optical technology developed by a Northwestern ... be effective in detecting the presence of pancreatic cancer ... to clinical trial results published in the journal ... which researchers hope could help raise the extremely low ...
... goals for the University of Houston,s department of health and ... expands to the National Center for Human Performance in the ... door to other investigators within the Medical Center who are ... professor and department chair. "This is the culmination of ...
... The Kidney TRUST,s Rapid-Screening Program Promotes Kidney Health ... a non-profit organization dedicated to chronic kidney disease ... Month and World Kidney Day on March 12 ... in Colorado, California, Texas, and Washington, D.C. throughout ...
... to influenza A strain, which is most common in US, ... troubling increase in resistance to the antiviral drug Tamiflu is ... season, a new government report shows. , Almost 100 percent ... the drug, up from 12 percent during last year,s flu ...
Cached Medicine News:Health News:Steelworkers Say President's Choice for Health and Human Services a Good One 2Health News:Susan G. Komen for the Cure(R) Advocacy Alliance Applauds Selection of Gov. Sebelius for Secretary of Health and Human Services 2Health News:Optical techniques show continued promise in detecting pancreatic cancer 2Health News:Optical techniques show continued promise in detecting pancreatic cancer 3Health News:Optical techniques show continued promise in detecting pancreatic cancer 4Health News:Motor behavioral research at UH moves to prestigious Texas Medical Center 2Health News:March Is National Kidney Month 2Health News:Resistance to Tamiflu Growing 2Health News:Resistance to Tamiflu Growing 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: