Navigation Links
New Nexavar Data Presented in Multiple Tumor Types at 44th American Society of Clinical Oncology Annual Meeting
Date:6/2/2008

en shown to target members of two classes of kinases known to be involved in both cell proliferation (growth) and angiogenesis (blood supply) -- two important processes that enable cancer growth. These kinases included Raf kinase, VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-B, KIT, FLT-3 and RET.

Nexavar is also being evaluated by the companies, international study groups, government agencies and individual investigators as a single agent or combination treatment in a wide range of cancers, including metastatic melanoma, lung cancer, breast cancer and as an adjuvant therapy for kidney cancer.

Important Safety Considerations For Patients Taking Nexavar

Based on the currently approved U.S. package insert for the treatment of patients with unresectable hepatocellular carcinoma and advanced kidney cancer, hypertension may occur early in the course of therapy and blood pressure should be monitored weekly during the first six weeks of therapy and treated as needed. In HCC patients, bleeding with a fatal outcome from any site was reported in 2.4% for Nexavar and 4% in placebo. The incidence of treatment-emergent cardiac ischemia/infarction was 2.7% for Nexavar vs. 1.3% for placebo. In RCC patients, incidence of bleeding regardless of causality was 15% for Nexavar vs. 8% for placebo and the incidence of treatment-emergent cardiac ischemia/infarction was 2.9% for Nexavar vs. 0.4% for placebo. Most common adverse events .20% related to Nexavar for both HCC and RCC were fatigue, weight loss, rash/desquamation, hand-foot skin reaction, alopecia, diarrhea, nausea, and abdominal pain. Grade 3/4 adverse events in HCC and RCC patients, respectively, were 45% for Nexavar vs. 32% for placebo and 38% for Nexavar and 28% for placebo. Women of child-bearing potential should be advised to avoid becoming pregnant and advised against breast-feeding. In cases of any severe or persistent side effects, temporary treatment interruption, dose modification or permanent discontinuation
'/>"/>

SOURCE Bayer HealthCare Pharmaceuticals, Inc.; OnyxPharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2 3 4 5 6

Related medicine technology :

1. Nexavar Significantly Improves Overall Survival by 47 Percent in Asia-Pacific Liver Cancer Study
2. Nexavar First FDA-Approved Drug Therapy for Liver Cancer
3. ZymoGenetics Reports Positive Phase 1 Results for IL-21 With Nexavar(R)
4. Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial
5. Preliminary Data from Ongoing Phase 1 Data of Investigational Anti-PD-1 Antibody Presented at American Society of Clinical Oncology Annual Meeting
6. Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments
7. New Analyses Presented at ASCO Reaffirmed Efficacy and Safety of TORISEL in Patients With Advanced Kidney Cancer
8. Data To Be Presented at ASCO Supports Potential of Peregrines Cotara(R) for the Treatment of Brain Cancer
9. About 60 Clinical Studies Regarding Schering-Ploughs Oncology Compounds Will be Presented at ASCO
10. Two DOXIL(R) Studies to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting
11. Treprostinil Data Presented at American Thoracic Society Conference Demonstrates Significant Clinical Progress in All Four Routes of Administration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... -- Israel Brain Technologies (IBT) has announced the ... 1 st International Brain Technology Conference, which ... in Tel Aviv , recently ranked as ... by the Wall Street Journal and the epicenter ... showcase the latest breakthroughs in neuroscience and brain technology and ...
(Date:5/23/2013)... May 23, 2013 Halozyme Therapeutics, Inc. ... appointment of David A. Ramsay ... most recently Vice President, Corporate Development at Halozyme. ... "With his established financial management experience and ... working in our commercial group for the last ...
(Date:5/23/2013)... 2013  Omeros Corporation (NASDAQ: OMER ... Application (IND) to evaluate OMS824 in Huntington,s disease ... Drug Administration (FDA). OMS824 selectively inhibits phosphodiesterase 10 ... brain linked to a wide range of diseases ... OMS824 has shown promising results in animal models ...
Breaking Medicine Technology:Israel Brain Technologies Announces Israel's 1st International Brain Technology Conference 2Israel Brain Technologies Announces Israel's 1st International Brain Technology Conference 3Halozyme Therapeutics Names David A. Ramsay Chief Financial Officer 2Investigational New Drug Application Cleared by FDA for OMS824 in Huntington's Disease 2Investigational New Drug Application Cleared by FDA for OMS824 in Huntington's Disease 3Investigational New Drug Application Cleared by FDA for OMS824 in Huntington's Disease 4
... Whenever someone needs high-quality drugs for less money, they are ... of the large choice of pharmacies, it may not be ... make things simpler and safer for anyone looking to buy ... website promotion is the responsibility of the renowned search ...
... 2011 /PRNewswire-Asia/ -- Winner Medical Group Inc. (Nasdaq: ... manufacturer of medical dressings, medical disposables and non-woven ... China, today announced that one of its subsidiaries, ... recently awarded a Cotton Processing Certificate by the ...
Cached Medicine Technology:New Online Pharmacy Rx-webmasters.com Allows Customers to Pay Less for High-Quality Drugs 2Winner Medical Obtains Cotton Processing Certificate from the State Development and Reform Commission 2Winner Medical Obtains Cotton Processing Certificate from the State Development and Reform Commission 3
(Date:5/23/2013)... Rottenstein Law Group LLP, a New York-based nationwide mass ... Center at http://www.rotlaw.com/tylenol , dedicated to issues that ... filing lawsuits. , The painkiller Tylenol (acetaminophen) has ... to a 2009 report from the U.S. Food and ... warned consumers against using more than the recommended dose ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 Dr. Katherine ... new charitable organization in Orange County, OCCares , will ... Orange County. The event details are as follows: , ... Academy Auditorium, 13732 Clinton Street, Garden Grove, CA 92843 , ... crossover music by Christian vocalists Charmaine & Jonathan Thulin. ...
(Date:5/23/2013)... The vast majority of Americans believe it’s ... their level of physical activity, the healthfulness of their ... taking that control. Those are among the findings ... Food & Health Survey. , According to the Survey, ... “a great deal of control” or “complete control” over ...
(Date:5/23/2013)... 2013 Click here to read the ... are increasingly seeing their success develop through merger ... according to new research carried out by MaRS ... company has compiled its research into a series of ... the research have shown the general trend that the ...
(Date:5/23/2013)... 2013 Jeanne Ettelson, president of ... popular and only free OCD support group in Chicago. ... for OCD sufferers, the group is lead by psychologists ... This allows group participants to learn accurate information ... Prevention. , “Participants in Beyond OCD’s support group ...
Breaking Medicine News(10 mins):Health News:Rottenstein Law Group LLP Now Accepting Tylenol Cases, Announces New Tylenol Lawsuit Information Center 2Health News:Dr. Katherine Ahn is Proud to Announce the Launch Her Family's New Charity OCCares 2Health News:Dr. Katherine Ahn is Proud to Announce the Launch Her Family's New Charity OCCares 3Health News:Americans Experience “Control Gap” Regarding Their Weight, Diet, Activity Level; Rate Their Overall Diet a “B-Minus” 2Health News:Americans Experience “Control Gap” Regarding Their Weight, Diet, Activity Level; Rate Their Overall Diet a “B-Minus” 3Health News:Americans Experience “Control Gap” Regarding Their Weight, Diet, Activity Level; Rate Their Overall Diet a “B-Minus” 4Health News:Merrill DataSite Releases New Comments: Trends amidst Canadian and US Tech M&A 2Health News:Merrill DataSite Releases New Comments: Trends amidst Canadian and US Tech M&A 3Health News:Merrill DataSite Releases New Comments: Trends amidst Canadian and US Tech M&A 4Health News:Beyond OCD Support Group Marks Fifth Anniversary 2
... a protein called IGF-1 not entirely successful, studies find ... that prostate cancer can be treated successfully just by ... factor (IGF-1) has been undermined by two new studies. ... a number of drug companies and academic researchers, stimulated ...
... Consumers flooded Castle Connolly,s,website http://www.castleconnolly.com in ... Top Doctors," offered in collaboration with the,award-winning newspaper ... alone,Tuesday, April 29th, Newsday,s online users viewed Castle ... to our usual heavy traffic,from other sources," said ...
... MIRAMAR, Fla., May 1 Nipro Diabetes Systems ... time to the market. The,pump helps control blood ... and 2,diabetes. Built for safety, reliability, accuracy and ... screens for easy programming.,Developed and manufactured in the ...
... to Make Ends Meet, HARRISBURG, Pa., May 1 ... the rising costs of health care,would be greatly helped ... care insurance for all, a Department of Agriculture official ... Food Bank, Deputy Secretary,of Agriculture Cheryl Cook said passage ...
... 1 Physicians Healthcare Management,Group, Inc. (Phyhealth) ... organizations (HMOs) in partnership with physicians, today,announced ... as medical director,of Phyhealth Plan Corporation., ... Orlando, Florida, who has,extensive experience as the ...
... with pregnancy outcomes, CHICAGO, May 1 With ... wants to remind mothers-to-be,that maintaining good oral health is ... Research suggests there may be an association between maternal ... In addition, a,recent study says that pregnant women with ...
Cached Medicine News:Health News:Complications Found in Proposed Prostate Cancer Treatment 2Health News:Castle Connolly's 'Long Island's Top Doctors' Published in Newsday Generates More Than 1.1 Million Views of Top Doctors' Profiles in Single Day 2Health News:Photo: Introduction of the Amigo Insulin Pump Offers a Lifestyle Where 'Life Has No Limits' 2Health News:Pennsylvania Agriculture Official Says Passage of PA ABC Crucial to Rural Communities 2Health News:Phyhealth Appoints Gerald H. Priceman as Medical Director 2Health News:Phyhealth Appoints Gerald H. Priceman as Medical Director 3Health News:American Dental Association Stresses Good Oral Health During Pregnancy 2
Solid 14 mm blades. Dull finish....
Angled for temporal approach. Open 14 mm rounded blades for patient comfort. Dull finish....
Open 14 mm blades of heavy 1 mm wire. Dull finish. Most popular size or model....
Open wire style blades allow complete manipulation of the phaco tip inside the eye. Lid control is excellent, exposure is maximized, and the likelihood of positive pressure is reduced....
Medicine Products: