Navigation Links
New Model Provides Insights Into Intravenous and Subcutaneous Immunoglobulin Pharmacokinetics in Patients With Primary Immunodeficiencies
Date:3/19/2011

determine the location and level of SCIG in different parts of the body after injection. Unlike IVIG, which is injected directly into the intravascular compartment, SCIG is injected into the extravascular compartment. Fluctuations in serum IgG after IVIG dosing, which were lower in the first half of the 30-day dosing cycle and higher in the second half of the cycle than would be anticipated, led the study authors to hypothesize that IgG must be distributed to multiple compartments in the body. This strongly supports the theory that IgG distribution from the intravascular to the extravascular compartment occurs early in the dosing cycle, with the reverse occurring later in the dosing cycle.

After SC injection into the extravascular space, the model describes the interplay between IgG being broken down before reaching the circulation and also salvaged from this space to be returned to the bloodstream. The fate of IgG is similar between IVIG and SCIG after it reaches the intravascular compartment.

"Clearly a need exists to better understand the highly complex pharmacokinetic interactions that take place after an infusion of IgG, especially SCIG, in areas of the body that are not traditionally monitored by clinicians," said Stephen Jolles, M.D., University Hospital of Wales, Cardiff, U.K. "This new PK model represents a major step toward filling this need, especially for clinicians who measure serum IgG as a means of determining overall levels of IgG, and provides valuable insight into movement of IgG around the body with implications for improving PI patient dosing and treatment."

About Primary ImmunodeficienciesPrimary immunodeficiency (PI) is a group of more than 150 diseases that affect the cells, tissues and proteins of the immune system.(1) In people with PI, the immune system is either absent or functioning inadequately, leaving them more susceptible to infection.(2) For individuals with PI – many of them children – infectio
'/>"/>

SOURCE CSL Behring
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. PAREXEL Experts To Address Best-Practice Strategic Partnership Models To Increase Operating Efficiency, Development Effectiveness at Partnerships in Clinical Trials
2. FDA Approves Revised Alphanate® Labeling to Include Reduced Infectivity of an Experimental Model Agent for vCJD
3. S*BIOs Novel Dual mTOR/PI3 Kinase Inhibitor SB2343 Demonstrates Excellent PK/PD Properties Leading to Significant Anti-Tumor Efficacy in Xenograft Models
4. Reportlinker Adds Drug Device Combination Market to 2016 - Technological Convergence to be the New Business Model for Growth and Profitability
5. Nonin Medical, Inc. Launches New WristOx2™, Model 3150 in U.S. and Canada
6. Maldonado Medicals Green Initiative, a Model for the American Small Business
7. MedWOW Adds Parts Finder Service and Enhances Business Model
8. CareFusion Recall of Alaris PC Units Model 8015 Classified as Class I Recall
9. Transposagen Announces Exclusive License with Charles River Laboratories for p53 and Bcrp TGEM™ Knockout Rat Models
10. Reportlinker Adds Sales Force Effectiveness in Pharmaceuticals - Cost Pressures Increase Pharmaceutical Companies Adoption of New Sales Models and Technologies
11. Tengion Presents New Data Demonstrating Functional Regeneration in a Diabetic Chronic Kidney Failure Model at the International Society for Cellular Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... DALLAS , July 11, 2014 ... report "Scintillator Market by Composition of Material, Application ... and others), End Product (Personal Instrument, Hand-Held Instruments, ... Forecast and Analysis to 2013 - 2020", published by MarketsandMarkets, ... a CAGR of 5.62% from 2014 to 2020, ...
(Date:7/11/2014)... On Thursday, July 10, ... Dow Jones Industrial Average finished the day 0.42% lower at ... The losses were broad based as eight out of ten ... Care Sector Index ended the day at 711.88, down 0.02%, ... month. Investor-Edge has initiated coverage on the following equities: Covidien ...
(Date:7/11/2014)... LONDON , July 11, 2014 /PRNewswire/ ... of visitors to Safety & Health Expo ... by the move to London ... senior management attending exhibition.     ... (Photo: http://photos.prnewswire.com/prnh/20140711/696892-a ) ...
Breaking Medicine Technology:Scintillator Market will be worth $479.16 Million by 2020 2Scintillator Market will be worth $479.16 Million by 2020 3Scintillator Market will be worth $479.16 Million by 2020 4Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 2UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 3UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 4
... /PRNewswire/ -- Ethicon Endo-Surgery, Inc. today announced ... IDE feasibility trial. The case, which was performed at ... Invasive Surgery, marks the first natural orifice translumenal endoscopic ... NOTES is a surgical method in which external incisions ...
... 9 Approximately ninety-one percent of dentists say patients complaining ... nationwide member survey conducted by the Academy of General Dentistry ... by a decrease in salivary function. It affects approximately ... people at risk for tooth decay. During the Academy of ...
Cached Medicine Technology:First Patient of NOTES Investigational Device Exemption (IDE) Study Successfully Treated With Ethicon Endo-Surgery Devices 2First Patient of NOTES Investigational Device Exemption (IDE) Study Successfully Treated With Ethicon Endo-Surgery Devices 3Dry Mouth Linked to Prescription and Over the Counter Drugs 2Dry Mouth Linked to Prescription and Over the Counter Drugs 3
(Date:7/12/2014)... News) -- Burn injuries increase in the summer as people ... experts. Among those most vulnerable to these seasonal fire hazards: ... often get burned by putting their hands on the side ... burn unit at Loyola University Medical Center in Maywood, Ill., ... of ,When you play with fire, you get burned, is ...
(Date:7/12/2014)... Lindsay, ON Canada (PRWEB) July 12, 2014 Sean ... known for throwing out special challenges to his clients. He’s also ... Girls Club. He recently found a way to combine the two ... has raised $2,000 for the Boys and Girls Club. , ... Loss Program, which started on June 23rd. Francis sent out emails ...
(Date:7/12/2014)... Using and carrying around a catheter ... from Ashland, Va., decided that there needed to be ... to conceive of our design," he said. , They ... which provides an inconspicuous way to use and carry ... as promotes comfort and peace of mind. Producible in ...
(Date:7/12/2014)... With prom shopping reaching its final days, VogueQueen.com, ... to showcase its new and trendy apparels. Recently, the ... in its online shop. Additionally, it is now providing ... gowns. According to the company’s sales manager, the promotion ... , He says, “Now, worldwide clients can order ...
(Date:7/12/2014)... Wright & Schulte LLC has filed a DePuy ... of Johnson & Johnson, on behalf of an Ohio man ... metal-on-metal DePuy Pinnacle hip replacement and had to undergo revision ... The DePuy hip lawsuit was filed July 7, 2014, in ... 3:14-cv-2427) where DePuy Pinnacle Hip lawsuit litigation is underway ...
Breaking Medicine News(10 mins):Health News:Burn Injuries More Common in Summer 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 3Health News:VogueQueen.com Updates Its Summer Collection With New And Trendy Evening Dresses 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 5
... people who get lots of vitamin E in their ... those who take in relatively little. Researchers once had high ... important safeguard against heart attacks. But that idea eventually faded ... some think the vitamin may protect against cancer perhaps by ...
... prostate cancer would rather find out sooner than later if ... cancer using the prostate-specific antigen test. But since PSA levels normally ... to know what a high reading is and what may just ... have to undergo repeated biopsies to determine whether they have cancer ...
... a recent study done on rats has shed light on ... brain cell in a rat can make its whiskers twitch, ... controls movement. Eventually this could help scientists develop devices paralyzed ... researchers say they thought that because the part of the ...
... ( an evolution specialist ), helped China's SARS Epidemiology ... fingerprinted virus samples from several dozen infected people and ... provides more evidence that SARS jumps from animals to ... of new cases is crucial, before viral strains have ...
... study shows there may be reason to believe we have ... brain may block unwanted memories. ,Researchers from Stanford University ... were given 36 pairs of unrelated words and asked to ... word pairs into three sets of 12. Participants were asked ...
... research presented at the annual meeting of the Radiological ... accurately detect small cancers and stones in the kidneys, ... ,Multi Detector CT Urography ( MDCTU ) scans can ... through the body from different angles. Patients are given ...
Cached Medicine News:Health News:Vitamin E Found To reduce bladder cancer risk 2Health News:Scientists Have Traced How The SARS Virus evolved 2Health News:CT Scans Said to Accurately Detect Small Cancers 2
... specifically designed for monitoring the performance ... for separation and quantification of cholesterol ... in patient serum samples. Liposure is ... and A (IDL), LDL subfractions, HDL ...
... The Lipoprint System is a high resolution diagnostic ... tested by other methods. The test procedure is ... three hours. Any abnormal value is clearly flagged. ... highly atherogenic, small dense LDL in red and ...
... the only control for monitoring ... synovial fluid samples performed manually ... also an aid for identifying ... a pathological condition present in ...
... Suitable for use with ... BR2 bilirubinometers (pediatric) and all ... instruments including Aeroset, AU Series, ... Vitros. These controls contain purified ...
Medicine Products: