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New Model Provides Insights Into Intravenous and Subcutaneous Immunoglobulin Pharmacokinetics in Patients With Primary Immunodeficiencies
Date:3/19/2011

determine the location and level of SCIG in different parts of the body after injection. Unlike IVIG, which is injected directly into the intravascular compartment, SCIG is injected into the extravascular compartment. Fluctuations in serum IgG after IVIG dosing, which were lower in the first half of the 30-day dosing cycle and higher in the second half of the cycle than would be anticipated, led the study authors to hypothesize that IgG must be distributed to multiple compartments in the body. This strongly supports the theory that IgG distribution from the intravascular to the extravascular compartment occurs early in the dosing cycle, with the reverse occurring later in the dosing cycle.

After SC injection into the extravascular space, the model describes the interplay between IgG being broken down before reaching the circulation and also salvaged from this space to be returned to the bloodstream. The fate of IgG is similar between IVIG and SCIG after it reaches the intravascular compartment.

"Clearly a need exists to better understand the highly complex pharmacokinetic interactions that take place after an infusion of IgG, especially SCIG, in areas of the body that are not traditionally monitored by clinicians," said Stephen Jolles, M.D., University Hospital of Wales, Cardiff, U.K. "This new PK model represents a major step toward filling this need, especially for clinicians who measure serum IgG as a means of determining overall levels of IgG, and provides valuable insight into movement of IgG around the body with implications for improving PI patient dosing and treatment."

About Primary ImmunodeficienciesPrimary immunodeficiency (PI) is a group of more than 150 diseases that affect the cells, tissues and proteins of the immune system.(1) In people with PI, the immune system is either absent or functioning inadequately, leaving them more susceptible to infection.(2) For individuals with PI – many of them children – infectio
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SOURCE CSL Behring
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