Navigation Links
New Model Provides Insights Into Intravenous and Subcutaneous Immunoglobulin Pharmacokinetics in Patients With Primary Immunodeficiencies
Date:3/19/2011

KING OF PRUSSIA, Pa., March 19, 2011 /PRNewswire/ -- CSL Behring today announced the development of an innovative pharmacokinetic (PK) model that allows the absorption, distribution, metabolism, and elimination of subcutaneous (SC) immunoglobulin G (IgG) following administration to be simulated with a high degree of accuracy and precision. The new PK model provides a novel means of simulating the mechanism by which SC IgG is transported after it is injected into the subcutaneous tissue. Data from the model, which was developed by CSL Behring in collaboration with researchers at Cardiff University, Keele University, and Prism Ideas Ltd, were described in both a poster presentation and an oral presentation at the 2011 American Academy of Allergy, Asthma and Immunology annual meeting.

The current understanding of the clinical implications of SC versus intravenous (IV) dosing of IgG in primary immunodeficiency (PI) patients is limited. In addition, little is known about where SC IgG travels within the body after it is administered and how long it remains there. This information defines IgG's pharmacokinetic (PK) profile and could affect the volume and frequency of IgG dosing for PI patients.

"At CSL Behring we are continually searching for and identifying ways of improving treatment for patients with primary immunodeficiencies," said Martin Bexon, M.D., Program Director, Global Clinical Research and Development at CSL Behring. "This model increases our knowledge of how SC IgG is distributed throughout the body and has the potential to help us further optimize a dosing schedule that balances the convenience and therapeutic value of Hizentra for PI patients."

The new PK model, presented at this meeting in both a poster (Bexon et al; Poster 46; Session 2203) and an oral presentation (Jolles et al; Session 4602) describes a complex system of continuous interactions between extravascular (tissue) and intravascular (blood) compartments that help
'/>"/>

SOURCE CSL Behring
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. PAREXEL Experts To Address Best-Practice Strategic Partnership Models To Increase Operating Efficiency, Development Effectiveness at Partnerships in Clinical Trials
2. FDA Approves Revised Alphanate® Labeling to Include Reduced Infectivity of an Experimental Model Agent for vCJD
3. S*BIOs Novel Dual mTOR/PI3 Kinase Inhibitor SB2343 Demonstrates Excellent PK/PD Properties Leading to Significant Anti-Tumor Efficacy in Xenograft Models
4. Reportlinker Adds Drug Device Combination Market to 2016 - Technological Convergence to be the New Business Model for Growth and Profitability
5. Nonin Medical, Inc. Launches New WristOx2™, Model 3150 in U.S. and Canada
6. Maldonado Medicals Green Initiative, a Model for the American Small Business
7. MedWOW Adds Parts Finder Service and Enhances Business Model
8. CareFusion Recall of Alaris PC Units Model 8015 Classified as Class I Recall
9. Transposagen Announces Exclusive License with Charles River Laboratories for p53 and Bcrp TGEM™ Knockout Rat Models
10. Reportlinker Adds Sales Force Effectiveness in Pharmaceuticals - Cost Pressures Increase Pharmaceutical Companies Adoption of New Sales Models and Technologies
11. Tengion Presents New Data Demonstrating Functional Regeneration in a Diabetic Chronic Kidney Failure Model at the International Society for Cellular Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... -- The International Trade Commission (ITC) issued its final decision in ... a notice issued on December 23, the ITC ruled in ... humidifier was invalid. BMC President, James Xu ... excited with the ITC,s decision in this case. This victory ... the very beginning on the key patents in the case. ...
(Date:12/24/2014)... FARMINGTON, Conn. , Dec. 24, ... PTN), a biopharmaceutical company developing targeted, receptor-specific peptide ... unmet medical need and commercial potential, today announced ... of 2,050,000 shares of its common stock and ... its common stock.  Funds under the management of ...
(Date:12/24/2014)... PHILADELPHIA , Dec. 23, 2014 ... a medical device company focused on skin permeation, ... that Scott W. Hollander has been ... Mr. Hollander has more than 20 years of ... equipment industries, and most recently served as Vice ...
Breaking Medicine Technology:ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3
... 17, 2011 Damage to the spine can happen for ... car accident, wear and tear from old age, or blunt ... past have had to deal with back braces, reduced mobility, ... Seyed M. Rezaian,s patented Spinal Fixator, patients are able to ...
... Unilife Corporation ("Unilife" or the "Company") (NASDAQ: ... Deputy Secretary of the U.S. Department of Agriculture, for a ... at its facility in York, Pennsylvania. The White ... direction of President Obama. The Winning the Future Roundtables ...
Cached Medicine Technology:Dr. Seyed M. Rezaian's Spinal Fixator a Revolutionary Invention for Healing Injuries of the Thoracolumbar Spine 2Unilife Hosts White House Business Council Meeting 2Unilife Hosts White House Business Council Meeting 3
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... The report “TS-1 (Colorectal Cancer) – ... current treatment landscape, unmet needs, current pipeline and commercial ... anti-cancer drug which is typically used for treating colorectal ... for treating gastric cancer and pancreatic cancer. TS-1 is ... was first approved in 1999 in Japan for the ...
(Date:12/25/2014)... “Every three months the trends for ... evening dress will be one of the hottest styles in ... says. Today, the company releases 26 A-line sweetheart evening dresses, ... off. , “We are trying our best to help ... latest designs. Along with affordable prices, we provide discounted delivery ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 Recently, Dylan ... dresses, has excitedly released its collection of discounted prom ... to Percy, a senior spokesman of the company, the ... of this promotion is to expand the UK market. ... in several different colors, lengths, and styles: A-line strapless, ...
(Date:12/25/2014)... December 25, 2014 Recently, BellasDress ... on all its wedding dresses. BellasDress has chosen their ... for gift choices for the holiday season. , ... pick suitable wedding gowns here at discount prices. The ... experience at its website. , “All our ...
Breaking Medicine News(10 mins):Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... for future treatments, researchers say , MONDAY, March 22 ... with an increased risk for lung cancer in people ... analyzed DNA from more than 1,000 people with lung ... found strong evidence that two variations in a gene ...
... , ... medical marketing newsletter Healthcare Success Marketing Advisor has just surpassed the 10,000 subscriber milestone. ... (PRWEB) March ... Healthcare Success Marketing Advisor has just surpassed over 10,000 subscribers., , ,Written and ...
... Today, the U.S. Agency for International Development (USAID) ... US$12.7 million in their global partnership, the Water ... eight new multi-year programs throughout sub-Saharan Africa in Angola ... Mozambique , Senegal , South Africa , ...
... , March 22 Actress and philanthropist Holly Robinson Peete has partnered with ... example" by making smart food choices their children can emulate. MHAIA,s goal is to help reduce the ... ... ...
... ... trial, funded by the Mesothelioma Applied Research Foundation, publishes successful results for mesothelioma treatment. ... (PRWEB) ... trial to be well-tolerated and capable of inducing an immunological response against mesothelioma cells ...
... ... Hawaii , is unveiling a new, interactive website geared toward educating web visitors about state-of-the-art ... ... obesity, weighing 80 pounds or more over the average for their size and body type. ...
Cached Medicine News:Health News:Medical Marketing Newsletter Reaches 10,000 Subscribers 2Health News:The Coca-Cola Company and USAID Expand Global Water Partnership 2Health News:The Coca-Cola Company and USAID Expand Global Water Partnership 3Health News:The Coca-Cola Company and USAID Expand Global Water Partnership 4Health News:The Coca-Cola Company and USAID Expand Global Water Partnership 5Health News:The Coca-Cola Company and USAID Expand Global Water Partnership 6Health News:Avocados from Mexico Encourages Parents to Model Good Eating Habits 2Health News:Avocados from Mexico Encourages Parents to Model Good Eating Habits 3Health News:Avocados from Mexico Encourages Parents to Model Good Eating Habits 4Health News:New Mesothelioma Treatment Shows Promise 2Health News:Honolulu, Hawaii Bariatric Surgery Practice Launches New Website to Reach Out to Patients Fighting Morbid Obesity 2Health News:Honolulu, Hawaii Bariatric Surgery Practice Launches New Website to Reach Out to Patients Fighting Morbid Obesity 3
... A fixed pipette is ... a single volume. Fixed volume ... and advantages as other Finnpipette ... design, Super blow-out (1-40ul), Soft-touch ...
Inquire...
... is precision, ergonomics, and value!, ... with soft non-slip, contoured handle , ... light plunger spring action , Completely ... without the need for recalibration , ...
100L...
Medicine Products: