BASEL, Switzerland, June 11 /PRNewswire-FirstCall/ --
- Data Published in the British Journal of Cancer Reports That NeoRecormon use has no Negative Impact on Overall Survival or Tumour Progression
A new meta-analysis of all 12 prospective, randomised, controlled studies in 2,301 cancer patients shows that treating anaemia with NeoRecormon(R) (epoetin beta) has no negative impact on survival, tumour progression or deaths caused by blood clots, when used within its approved indications (1).
These encouraging results reported in the British Journal of Cancer,
June 2008, showed no new safety concerns with NeoRecormon when used in
accordance with its label and current EORTC guidelines.
Key findings of the meta-analysis
- No statistically significant difference in terms of overall survival
between patients receiving NeoRecormon or control.
- No statistically significant difference in disease progression between
NeoRecormon and the control groups, however there was a trend in favour
of a reduced risk of disease progression among NeoRecormon-treated
- There was an increased incidence of thromboembolic events (TEE) in the
NeoRecormon group (7.1% vs. 4.4%). This is consistent with the risk
observed in the erythropoiesis stimulating agent (ESA) class in
general, known by Health Authorities and described in all ESA labels.
There was no difference in the incidence of serious (4% vs. 3%) or
fatal TEEs (1% vs. 1%) for the NeoRecormon and control groups
About the meta-analysis
- The meta-analysis was conducted to evaluate differences between
NeoRecormon and control (placebo or standard care) with regard to
overall survival, disease progression and TEEs.
- In contrast to other conventional meta-analyses, in this meta-analysis
individual patient level data and not study leve
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