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New MTHFR Gene Test Extends Holistic Pharmacogenomics Approach to Treating Depression
Date:11/4/2013

MASON, Ohio, Nov. 4, 2013 /PRNewswire/ -- Assurex Health, a leading personalized medicine company, announced today the release of GeneSight® MTHFR, the latest addition to its pharmacogenomic test panel. GeneSight MTHFR determines the alleles at the C677T polymorphism in the MTHFR gene to predict effects on folic acid conversion.  An individual's genetic inability to convert folic acid into l-methylfolate has been linked to higher incidence of depression.

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The Assurex Health Clinical Development team analyzed 112 published articles and clinical studies examining the association between C677T polymorphisms and circulating homocysteine and folate levels. Over 90% of studies found a statistically significant positive association between reduced conversion of folic acid and the T allele.  Patients with reduced folate levels may benefit from folic acid or folate supplementation.

MTHFR will be the fourth GeneSight test, joining other GeneSight tests already available for patients diagnosed with depression, anxiety, bipolar disorder, schizophrenia, ADHD and chronic pain. Like the other GeneSight tests, GeneSight MTHFR uses a patient's DNA, collected via a simple cheek swab, and matches it with all relevant treatment information to provide support to clinicians to help get patients on the right regimens faster.

"The addition of GeneSight MTHFR to Assurex Health's suite of neuropsychiatric personalized medicine products will further enable clinicians to personalize and optimize treatment for patients suffering from mental illness," according to Bryan M. Dechairo, Ph.D., Senior Vice President, Medical Affairs & Clinical Development at Assurex Health. "Prescribing a genetically informed treatment regimen helps the clinician bett
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SOURCE Assurex Health
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