New MIRCERA(R) Data Analyses to be Featured at the American Society of Nephrology Annu...(th C.E.R.A. in patients (pts) with chron...),Health

disease (CKD) is unaffected by baseline hemoglobin (Hb) level. R.

Provenzano et al. (SU-PO796. November 4: 10:00 a.m. - 12:00 p.m. PST.

Exhibit Hall, Moscone Center)

-- Median hemoglobin (Hb) decline following C.E.R.A. dose interruption is

similar to that with other erythropoiesis stimulating agents (ESAs). P.

Barany et al. (SU-PO795. November 4: 10:00 a.m. - 12:00 p.m. PST.

Exhibit Hall, Moscone Center)

-- Diabetes status and ethnicity do not alter efficacy of C.E.R.A. in

patients with chronic kidney disease: analysis of 3 phase III trials.

T. Golper et al. (SU-PO1019. November 4: 10:00 a.m. - 12:00 p.m. PST.

Exhibit Hall, Moscone Center)

-- C.E.R.A. maintains hemoglobin in dialysis patients directly switched

from epoetin (EPO) without increasing iron therapy requirements. A.

Nissenson et al. (F-PO855. November 2: 10:00 a.m. - 12:00 p.m. PDT.

Exhibit Hall, Moscone Center)

-- C.E.R.A. every 2 or 4 weeks maintains hemoglobin control in CKD

patients on dialysis with and without congestive heart failure: pooled

Phase III analysis. S. Fishbane et al. (F-PO843. November 2:

10:00 a.m. - 12:00 p.m. PDT. Exhibit Hall, Moscone Center)

About MIRCERA

The clinical program for MIRCERA consisted of 10 global studies involving more than 2,700 patients from 29 countries. The Phase III program for MIRCERA included two correction studies and four maintenance studies exploring intravenous (IV) and subcutaneous (SC) MIRCERA at extended administration intervals.

MIRCERA has a longer half-life than any commercially available erythropoiesis-stimulating agent (ESA). In clinical trials MIRCERA corrected anemia in chronic kidney disease (CKD) patients with dosing once every two weeks and maintained hemoglobin levels in CKD patients with dosing intervals up to once
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