Navigation Links
New Intra-Nasal Cooling System May Improve Survival When Initiated Soon After Cardiac Arrest
Date:8/16/2010

New Intra-Nasal Cooling System May Improve Survival When Initiated Soon After... -- SAN DIEGO, California, August 16, 2010 /PRNewswire/ --


Advanced Search Search

  
Close
  1. Send a release
  2. Member sign in
  3. Become a member
  4. For journalists
  5. Global sites
PR Newswire: news distribution, targeting and monitoring
  1. Products & Services
  2. Knowledge Center
  3. Browse News Releases
  4. Contact PR Newswire
Publishing & Information Services, Health Care & Hospitals, Medical Equipment, Medical Pharmaceuticals, New Products & Services, Surveys, Polls and Research, Clinical Trials & Medical Discoveries Click to view news release full screen  

New Intra-Nasal Cooling System May Improve Survival When Initiated Soon After Cardiac Arrest

 

SAN DIEGO, California, August 16, 2010 /PRNewswire/ -- A new portable system which cools the brain via the nasal cavity may improve survival following cardiac arrest compared with standard care procedures, particularly when CPR and cooling are initiated early. Results from a recent study showed that the RhinoChill(TM) Intra-Nasal Cooling System enabled brain temperature to reach target several hours earlier than patients cooled in the emergency room. It is widely recognized that the sooner brain temperature can be reduced, the better the chances of minimizing long-term damage.

The study, published online in the prestigious peer-reviewed journal Circulation, is the first to evaluate cooling using this system in a randomized protocol conducted in the field and during the arrest. The Pre-Resuscitation Intra-Nasal Cooling Effectiveness (PRINCE) study involved 200 patients with witnessed cardiac arrest across 15 locations in Belgium, Germany, Italy, Czech Republic and Sweden, where cardiopulmonary resuscitation (CPR) had been initiated within 20 minutes of collapse. Patients were randomized to either intra-nasal cooling with RhinoChill along with standard advanced cardiac life support (ACLS) care or ACLS alone until they were either resuscitated or reached hospital, at which stage patients in both groups were cooled.

Results showed that the target tympanic temperature of 34 degreesC, used as an approximation of brain temperature, was reached three hours earlier in the group receiving pre-hospital cooling with RhinoChill. Target core body temperature was also reached two hours earlier. Among patients surviving as far as hospital admission, 47% of patients who were cooled survived to discharge, compared with only 31% of those who had not been cooled. Survival rates in the 75% of patients who received CPR within ten minutes of collapse were 59% and 29% respectively.

37% of those cooled intranasally during the arrest survived neurologically intact, compared with only 21% of those not cooled in the field. Neurologically intact survival rates in patients who received CPR within ten minutes of collapse were 46% and 18% respectively, a very significant difference.

"In this study, early cooling of the brain combined with early CPR favorably affected outcomes, irrespective of rhythm," commented PRINCE lead investigator, Dr. Maaret Castren of the Department of Clinical Science and Education, Karolinska Institute, Stockholm, Sweden and the Department of Emergency Medicine, Sodersjukhuset. "We believe that this study demonstrates that making every attempt to initiate both CPR and intra-arrest cooling as early as possible in the resuscitation process should be adopted."

In an accompanying editorial to the PRINCE study published in Circulation, Dr. Lance Becker from the University of Pennsylvania observes that: 'Although the numbers are too small to reach significance, they provide some tantalizing cooling rates and survival trends that suggest that improved outcomes from intra-arrest nasal cooling may be found in a larger clinical trial.'

He also comments that: 'A strength of this approach [RhinoChill] appears to be its relative noninvasiveness and ease of administration. It may prove an ideal device for the emergency medical services setting.'

The RhinoChill Intra-Nasal Cooling System uses a non-invasive nasal catheter to spray a rapidly evaporating coolant liquid into the nasal cavity. This large nasal cavity is a heat exchanger and lies right under the brain. The system's portability and ease of use mean that cooling of the brain can be initiated much sooner after a cardiac arrest than with traditional devices, which cannot be used until the patient reaches hospital.

Cardiac arrest shuts off blood flow to the brain, and death can start within four to six minutes if circulation is not quickly restored. Resuscitated patients may suffer brain injury due to lack of oxygen, and because restored blood flow can cause inflammation in damaged tissues. Cooling the brain reduces its need for oxygen and slows the damage processes.

The RhinoChill System received CE Mark Approval for marketing in European Union countries in December 2007. It is currently planned to commence launches in selected European markets from October 2010. The RhinoChill System is not for sale in the USA.

For further information, please contact:

Richard Kenyon: +44-7831-569940; richard@rkpr.co.uk


'/>"/>
SOURCE Circulation
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Cardiums InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology
2. Arctic Sun Therapeutic Cooling Device at Center of Heroic Rescue
3. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
4. CardioFocus Endoscopic Ablation System Earns CE Mark to Treat Atrial Fibrillation; US Clinical Investigation Underway
5. Siemens Preclinical Imaging System Helps The Methodist Hospital in Houston Further Its Research Mission
6. Syndicom SpineConnect Web Platform Chosen for Applied Spines Leg and Back Pain Clinical Trial of Its Stabilimax NZ(R) Dynamic Spine Stabilization System
7. Life Recovery Systems Receives European CE Mark Approval for Its ThermoSuit(R) System
8. New Topical Therapy Safely Treats Serious Skin Infections Without Systemic Side Effects
9. Flexible Medical Systems Raises $1.2M Seed Investment for Initial Human Trials
10. Abbott Initiates Clinical Study to Evaluate Use of RX Herculink(R) Elite(TM) Renal Stent System for the Treatment of Renal Artery Stenosis
11. Neupro(R) (Rotigotine Transdermal System) Effective in Controlling Early Morning Motor Impairment and Generally Well-Tolerated for Long-Term Use in Patients with Parkinsons Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... On Thursday, Feb. 11, 2016, surgeons at ... North Austin Medical Center successfully completed the first robotic ... Surgical System with Trumpf Medical,s advanced operating table, ... , M.D., colorectal surgeon at the Texas Institute for ... Motion technology, which seamlessly combines the da Vinci Xi ...
(Date:2/12/2016)... 12, 2016  Eli Lilly and Company (NYSE: LLY ... Alimta® (pemetrexed disodium) vitamin regimen patent would not presently be ... France , Italy and ... product only with dextrose solution.  --> ... Court of Appeal held that Lilly,s patent would be indirectly ...
(Date:2/12/2016)... Ga. , Feb. 12 2016  OMS Supply, ... dental and medical practitioners, announced today the recent launching ... offers visitors a variety of features that enhance the ... oral surgery supplies. --> ... is a fairly new company that started in early ...
Breaking Medicine Technology:
(Date:2/13/2016)... ... February 13, 2016 , ... ... top Clinical Data Management Solution Providers list for its expertise in eClinical Solutions. ... domain expertise to serve the technology needs of global clients. DDi provides smarter ...
(Date:2/12/2016)... TX (PRWEB) , ... February 12, 2016 , ... Mystic ... as expressed in Blue SKies Buddha, the biography of Rama - Dr. Frederick Lenz. ... a love story, the love of a Buddhist teacher for teaching and helping others. ...
(Date:2/12/2016)... WA, and Washington, DC (PRWEB) , ... ... ... PATH and the Siemens Foundation today announced a new initiative—the Siemens Foundation-PATH ... for low-resource settings. The partnership will recruit top students from U.S. universities ...
(Date:2/12/2016)... ... February 12, 2016 , ... CDRH Enforcement Trends: , Back to the Future , Feb. ... , As Winston Churchill said, “Those who don’t learn from history are doomed to repeat ... when they come knocking this year. But that takes time. , Take a close ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Each year, ... will be held in Anaheim, CA at the Anaheim Convention Center. Almost 10,000 physical ... see new therapy products in action, learn more about their chosen field and network ...
Breaking Medicine News(10 mins):