Navigation Links
New Insights Provide Promise for Development of Tools to Protect Damaged Tissues
Date:9/13/2010

ly attributed to a decrease in the breakdown of p53 inside such cells. But in 2005, Kastan and his colleagues showed that affected cells also produce more of the protein. Researchers reported that after DNA damage, a protein called RPL26 binds to a molecule called p53 messenger RNA, leading to a dramatic rise in p53 protein. Messenger RNA (mRNA) is part of the cell's protein production machinery that translates the genetic instructions inside cells into needed proteins.

Efforts to better understand how RPL26 functioned led investigators to this latest discovery. Researchers showed that optimal p53 production required RPL26 to bind to a structure in mRNA not previously seen in mammalian cells.

The structure forms when the ends of the normally single-stranded mRNA molecule come together and make a short region of double-stranded RNA. Those ends must obey the rules of RNA pairing and link only with a complementary molecule, or base pair, on the other strand. "We suspect we will find a whole family of stress-related proteins regulated this way," Kastan said.

Investigators showed that blocking the interaction at either end of the mRNA was enough to short-circuit RPL26 binding and lead to a dramatic fall in p53 protein levels in stressed or damaged cells.

Researchers used short pieces of DNA, so small they were absorbed by cells after simply being added to cell culture, to target the interactive bases and successfully disrupt formation of the double-stranded structure. Restoring the ability of the bases to bind the two ends of the mRNA restored RPL26 binding and stimulated p53 protein synthesis.

Work is underway to develop a mouse model to speed efforts to find or design small molecules that target this mechanism. "We have a long way to go in terms of drug development, but the better we can define the interaction between RPL26 and the double-stranded RNA structure the more likely we will be able to develop other small molecules to sp
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. UBM TechInsights Expands Presence in the Medical Devices Sector
2. Adjusting Market Research Structures and Activities to Maximize Payer Access & Insights
3. Thought Leaders Shaping the Emerging Wireless Life Science Space to Share Vision and Insights at WLSA Convergence Summit
4. Craneware Shares Patient Estimation Revenue Integrity Insights
5. Strand to Develop and Market Breakthrough Software Solutions to Manage Insights Associated With Microscopy Images
6. Kendle Executive to Share Insights at World Pharma Trials Asia 2010
7. Looking Ahead to AES 2009: New Insights on Comorbidities and Other Considerations for Epilepsy Treatment
8. Euro RSCG Life Presents Proprietary Survey Insights at Food and Drug Administration Hearing on Pharmaceutical Promotion via Online and Social Media
9. Reportlinker Adds Impact of Counterfeits on Parallel Trade & Pharmaceutical Distribution: Issues, initiatives and insights for supply chain integrity
10. Kendle Experts to Share Insights at the Regulatory Affairs Professionals Society Annual Conference and Exhibition
11. VisEn Molecular Imaging Technology Enables Key Insights Into Newly Discovered Biologic Pathway Published in SCIENCE
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... , July 11, 2014 Patient ... marketing and, consequently, organizations are turning to an ... As part of this evolving approach ... to educate, communicate and engage patients throughout their ... to patient empowerment. By mapping the patient journey ...
(Date:7/11/2014)... July 11, 2014 Research and Markets ... Needles Market 2014-2018" report to their offering. ... hypodermic needle is a hollow needle commonly used with ... or to extract fluids from it. A hypodermic needle ... inject substances that cannot be ingested. Hypodermic needles are ...
(Date:7/11/2014)... DUBLIN , July 11, 2014 ... the addition of the "Immunoprotein Diagnostic Testing ... at the highest CAGR of 6% and is ... report to their offering. ... for immunoprotein diagnostic testing has been segmented according ...
Breaking Medicine Technology:New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2
(Date:7/13/2014)... Advanced boilers are preferred over conventional ... fossil fuels, produce high-capacity power, emit fewer pollutants, ... warming and climate change concerns, many countries have ... emissions and pollutants coming from fossilfuel-based power plants.North ... advance boilers market., The global power rental market ...
(Date:7/13/2014)... New York, New York (PRWEB) July 13, 2014 ... much to bring attention to the cancer risks associated ... a chance to tell their story to federal regulators, ... of a U.S. Food & Drug Administration (FDA) ... Liebhard LLP reports. According to the Rochester Democrat ...
(Date:7/13/2014)... New York (PRWEB) July 13, 2014 ... ( http://www.transvaginalmeshlawsuithelp.com/ ) filed against Johnson & ... second bellwether trial, which is expected to get underway ... issued in the U.S. District Court, Southern District of ... will be held on August 7, 2014 at 3:00 ...
(Date:7/13/2014)... 2014 Fadhits.com is popular among worldwide ... are extremely beautiful. Recently, the company has announced its ... 2014. What’s more, all these outfits are available at ... , Additionally, the supplier is now offering similar discounts ... dresses, it has many other designs for sale, including ...
(Date:7/13/2014)... July 13, 2014 According to the Kidney ... a step by step guide on what to do to ... and quickly. Vkool writes in its review that readers can ... eat to revitalize their kidney health. Vkool also informs in ... people reverse their damaged kidney functions naturally. The book consists ...
Breaking Medicine News(10 mins):Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 3Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 2Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 3Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 4Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 2Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 3Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 4Health News:Fadhits.com Announces a Special Offer on Elegant Quinceanera Dresses 2Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 2Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 3
... in the fight against skin cancer. A study showed ... gives more clarity for referring patients to a skin ... by IDIBAPS-Hospital Clinic, in collaboration with several Catalan and ... relieve the demand of dermatology consultations and reduces dramatically ...
... woman is enough to challenge a man’s decision-making skills, ... Men shown images of lingerie or sexy women before ... accept unfair offers. Furthermore, this effect was more pronounced ... study for the first time highlights that sexual signals ...
... over the past two decades. The current outbreak, the largest ... have begun in late 2005 at a university in eastern ... continuing to spread. ,According to latest information from the ... more than 1,000 cases reported so far, most of them, ...
... Americans whose diet was Mediterranean, that included lots of ... little dairy and meat, certainly had a low risk ... been published in the April issue of Annals of ... diet , Alzheimer’s development is greatly influenced with diet ...
... three persons with a history of fever were admitted Monday ... patients are currently under observation on suspicion of being hit ... 22-year-old Syed Wali, his 8-year-old sister Haleema and a 44-year-old ... of symptoms of bird flu. ,This the first ...
... conducted on a popular anti-ulcer pill used worldwide for inducing ... effective// as the other expensive drugs. Researchers have however urged ... ,The pill – a prostaglandin known generically as misoprostol and ... peptic ulcers and is not approved for use in pregnant ...
Cached Medicine News:Health News:Dermoscopy An Able Tool For The Fight Against Skin Cancer 2Health News:Sexy Images and Lingerie Challenge A Man’s Decision Making Skill 2Health News:Mumps Outbreak In The US 2Health News:Mumps Outbreak In The US 3Health News:Concerns About Popular Anti-Ulcer Pill Used For Inducing Labor 2Health News:Concerns About Popular Anti-Ulcer Pill Used For Inducing Labor 3
Inquire...
Quick Release Holder for the 8000 Series Sliding Microtome. A simple to use hlder for wax cassettes. Accepts standard size wax cassettes (26 x 31 x 5mm). Can be specified instead of standard vice ...
Tilt Adapter for the 8000 Sliding Microtome to allow for orientation of the specimen....
... new SureCut M3500 Radial Microtome has a look ... and a range of functions and capabilities that ... Based on years of experience and knowledge but ... the SureCut M3500 Microtome will be the answer ...
Medicine Products: