The study team also found an association between ulcerative colitis and genes on the major histocompatiblity complex (MHC) on chromosome 6. The MHC is a large group of genes with important roles in the immune system, and this finding may help refine diagnostic techniques that would allow physicians to administer more specific therapies to their patients.
The Center for Pediatric Inflammatory Bowel Disease at Children's Hospital currently treats 1,400 children annually for IBD, and has one of the world's largest clinical research programs for IBD. The Center for Applied Genomics, directed by Hakonarson, is currently the largest pediatric genotyping program in the world. The Center's highly automated analytic equipment scans each DNA sample for over half a million genetic markers.
Financial support for the study came from the National Institutes of Health, the IBD Family Research Council, the Crohn's and Colitis Foundation of America, the Koss Foundation, the NIH General Clinical Research Center of the Medical College of Wisconsin, the Primary Children's Medical Center Foundation, the Edmunds Fund, the Heineman Foundation, the Cotswold Foundation, and The Children's Hospital of Philadelphia, which funded all genotyping performed in the study.
Baldassano's and Hakonarson's co-authors included Struan Grant, Ph.D.,
Jonathan Bradfield, Ph.D., David A. Piccoli, M.D., Petar Mamula, M.D.,
Robert Grundmeier, M.D., and Dimitri Monos, Ph.D., all of Children's
Hospital. Other co-authors were Subra Kugathasan, M.D. (formerly of the
Medical College of Wisconsin and currently at Emory University), who is
co-first author with Baldassano; Stephen Guthery, M.D., of the University
of Utah; Gitit Tomer, M.D., and Lee Denson, M.D., of Cincinnati Children's
Hospital Medical Center; Salvatore Cucchiara, M.D., Ph.D., of Sapienza
University, Rome, Italy; and Vito Annese, M.D., of "Casa Sollievo della
|SOURCE Children's Hospital of Philadelphia|
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