Navigation Links
New Genes Found for Inflammatory Bowel Disease in Children
Date:8/31/2008

childhood tends to be more severe than adult-onset disease, and is more likely to affect the colon than other areas of the GI tract. Those age-related differences in IBD spurred the current research team to do their gene hunting in childhood-onset disease. "Although the gene variants we found may have a stronger signal in pediatric IBD than in adult- onset IBD, we do not believe them to be limited to varieties of the disease that begin in childhood," said Baldassano.

The researchers performed a genome-wide association study, searching for genetic variations in DNA samples from 1,000 patients with childhood-onset IBD, compared to samples from 4,250 healthy subjects. Both patients and controls were of European ancestry.

In addition to finding gene variations previously reported by other groups, the study team identified two novel gene variants, one on chromosome 20 and the other on chromosome 21. They then replicated their findings with studies using additional samples from other sources.

The researchers say that the TNFRSF6B gene on chromosome 20 is a compelling candidate, because it is already known to participate in the biological pathway of a protein called tumor necrosis factor (TNF). TNF is a cytokine, a chemical messenger that plays a key role in the harmful inflammation characteristic of IBD.

Some current treatments for IBD use monoclonal antibodies that selectively bind to a type of TNF involved in the disease (Among those drugs are infliximab, adalimumab and certolizumab). "As we better understand the complex gene interactions in IBD, we may be able to diagnose patients by their genetic profile to predict who will better respond to anti-TNF drugs," said Hakonarson. Anti-TNF medications such as those mentioned above are currently given intravenously or as injections, said Baldassano, who added, "If better knowledge of the disease pathway enables pharmaceutical companies to develop anti-TNF drugs in pill form, the medications will b
'/>"/>

SOURCE Children's Hospital of Philadelphia
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. National Jewish, Brigham and Womens Awarded $37 Million to Identify Genes and Other Risk Factors that Influence the Development of COPD
2. KineMed Presents Preclinical Data for Investigational Agent Demonstrating Neurogenesis and Confirming Improvements in Behavioral Model
3. Intradigm Study Shows Ability of siRNAs Systemically Delivered With TargeTran(TM) System to Suppress Tumor-Induced Angiogenesis in Mice
4. Interim Analysis Supports Continuation of Cell Genesys VITAL-1 Phase 3 Clinical Trial of GVAX Immunotherapy for Prostate Cancer
5. Steps Toward Stopping Autoimmune Disease: International Consortium Identifies Genes Linked to Lupus
6. Genomic Health Announces Identification of Genes Associated With Colon Cancer Recurrence Across Multiple Studies
7. ADVENTRX to Present ANX-201 Preclinical Data at Keystone Symposia HIV Pathogenesis Conference
8. deCODE Launches a DNA-Based Test for Assessing Risk of Prostate Cancer on the Back of the Discovery of New Prostate Cancer Genes
9. Cell Genesys Reports Association Between Immune Response and Patient Survival in Phase 2 Trial of GVAX Immunotherapy for Prostate Cancer
10. CorMatrix(R) Announces Intramyocardial Injection of Emulsified ECM Technology(TM) Demonstrates Enhanced Angiogenesis and Improved Cardiac Function in a Preclinical Model
11. Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... July 31, 2015 According to ... by Product (Bioimpedance Analyzers (BIA), Dual-Energy X-ray Absorptiometry (DEXA), ... - Global Analysis & Forecast to 2019", published by ... at $911.1 Million 2014 and is estimated to grow ... of 9.4% from 2014 to 2019. ...
(Date:7/30/2015)... DIEGO , July 30, 2015 /PRNewswire/ ... it has signed a definitive agreement to ... of non-invasive ventilation and sleep-disordered breathing medical ... clinical, innovation and market reputation in China, combined with ResMed,s global leadership in ... people in China ...
(Date:7/30/2015)... , July 30, 2015  EP Global Communications, ... have recently contacted the Company about discussing EPGL,s ... early as Monday, August 3, 2015.  Novartis CEO ... saying that the coming electronic contact lens market ... over the next several years.  Novartis partnered with ...
Breaking Medicine Technology:Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3
... Novel Biomarkers Displaying 90% Sensitivity in Breast ... ... announced today the,discovery and validation of the most frequent DNA alterations detected ... appeared in PLoS ONE. The study entitled, "Identification of,Novel High-Frequency DNA Methylation ...
... GeoVax Labs, Inc. (OTC,Bulletin Board: GOVX), an Atlanta-based ... has retained Financial,Relations Board (FRB), as its Investor ... HIV-1/AIDS vaccine human trial results need to be,conveyed ... AIDS,pandemic," stated Kathy Waller, co-president of FRB., ...
Cached Medicine Technology:Orion Genomics Announces the Discovery of Novel Breast Cancer Biomarkers 2GeoVax Labs, Inc. Selects Financial Relations Board as Investor Relations Counsel 2GeoVax Labs, Inc. Selects Financial Relations Board as Investor Relations Counsel 3GeoVax Labs, Inc. Selects Financial Relations Board as Investor Relations Counsel 4
(Date:7/31/2015)... ... July 31, 2015 , ... Recently, ZKB filed ... Ohio, Western Division (Case No. 3:15-cv-00397) involving the Implanon® contraceptive implant . ... migration of their Implanon® implants, inability to locate the implants, unsuccessful and invasive ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... The alarm was ringing. Hugh Chatfield, survivor ... out of the window, he recalled that his equipment was set up to depict the ... he jumped out of bed. , The photo speaks for itself. Chatfield is also a ...
(Date:7/31/2015)... ... July 31, 2015 , ... Patients with higher levels of ... study published today in Nature Communications and led by researchers from the Icahn School ... variations in the gene RTN1 led to greater production of the related RNT1 protein, ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... proud to announce that their latest designer handbag line will be named for ... an Internet sensation as the first globally recognized model with Down syndrome, gracing ...
(Date:7/31/2015)... ... July 31, 2015 , ... Healthpointe ... a newly redesigned website at Healthpointe.net. The new website will feature a sleek ... The redesign serves to provide smoother interactions between patients and the Healthpointe clinics ...
Breaking Medicine News(10 mins):Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 2Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 3Health News:Mount Sinai Researchers Find Key Gene Drives Kidney Disease Severity 2Health News:Mount Sinai Researchers Find Key Gene Drives Kidney Disease Severity 3Health News:everMaya to Launch Madeline Stuart Handbag Line 2Health News:everMaya to Launch Madeline Stuart Handbag Line 3Health News:Healthpointe Announces Newly Redesigned Website 2
... to reduce levels of bad cholesterol in the blood. Scientists ... the genes that bring about this beneficial effect. ... in the open-access journal PLoS Genetics, the research group has ... infarction and stroke can be prevented if levels of the ...
... writing, helps to ease patients, burden , , FRIDAY, March 14 ... University,s Lombardi Comprehensive Cancer Center for treatment of lymphoma, he ... how his cancer had changed him and how he felt ... IV in his left arm and a pen in his ...
... D.C., and Meet with Elected,Officials, WASHINGTON, March 14 ... Washington, D.C., this April 1 to meet with,congressional leaders ... Disabilities Act, support for epilepsy public health,programs and more ... is one of 50 young people with epilepsy participating ...
... Washington, D.C., and,Meet with Elected Officials, WASHINGTON, ... Schliesmann of Holmen will travel to Washington,D.C., this ... gain their,support for restoration of the Americans with ... more research toward a cure for,epilepsy., Benishek ...
... to Visit Washington, D.C., and Meet With Elected,Officials, ... travel to Washington, D.C., this April 1 to meet ... the,Americans with Disabilities Act, support for epilepsy public health,programs ... Zachery, 15, is one of 50 young people with ...
... NHS Choices ( http://www.nhs.uk ), the,digital ,front ... Live Well package on,pregnancy, aimed at helping ... during,pregnancy., Based on NHS accredited information, ... information about staying healthy and fit during ...
Cached Medicine News:Health News:Fighting Cancer With a Pen 2Health News:Fighting Cancer With a Pen 3Health News:Colorado Youth Named National Epilepsy Spokesperson 2Health News:Wisconsin Youths Named National Epilepsy Spokespersons 2Health News:Tennessee Youth Named National Epilepsy Spokesperson 2
... A necessary addition to ... the Reichert Trial Frame ... and smooth controls for ... robust design, high-quality materials, ...
... The Ultramatic Rx Master is ... years of reliable service and ... that measurably improve procedures. It ... need and want most, including ...
The Maverick Over-The-Wire balloon catheter delivers a new level of performance to meet the changing demands of interventional cardiology....
... Illumination is provided by a cool-running, ... light only what you need to see ... best of all they are maintenance free ... light bulb. Every Phoroptor comes with a ...
Medicine Products: