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New Gene Study of ADHD Points to Defects in Brain Signaling Pathways
Date:12/4/2011

tested in clinical trials as a potential therapy for ADHD in patients harboring particular CNVs. He added that further preclinical studies must first be done to evaluate candidate drugs.

Joseph T. Glessner, a Ph.D. trainee at the Center for Applied Genomics, is also a co-first author of the study along with Elia. Other collaborators were from numerous U.S. and European centers. Funding for the study came from an Institutional Development Award to the Center for Applied Genomics from The Children's Hospital of Philadelphia. Funding also came from the National Institutes of Health, the Cotswold Foundation, a University of Pennsylvania National Center for Research Resources Clinical and Translational Science Awards grant, the U.S. Department of Health and Human Services, and other sources.

"Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder, Nature Genetics, advance online publication on Dec. 4, 2011. doi: 10.1038/ng.1013

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking third in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 516-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu.

Contact: John Ascenzi
The Children's Hospital of Philadelphia
Phone: (267) 426-6055

SOURCE The Children's Hospital of Philadelphia
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