Navigation Links
New Gene Study of ADHD Points to Defects in Brain Signaling Pathways
Date:12/4/2011

ur genes with a significantly higher number of CNVs in children with ADHD. All the genes were members of the glutamate receptor gene family, with the strongest result in the gene GMR5. Glutamate is a neurotransmitter, a protein that transmits signals between neurons in the brain. "Members of  the GMR gene family, along with genes they interact with, affect nerve transmission, the formation of neurons, and interconnections in the brain, so the fact that children with ADHD are more likely to have alterations in these genes reinforces previous evidence that the GRM pathway is important in ADHD," said Hakonarson. "Our findings get to the cause of the ADHD symptoms in a subset of children with the disease."

"ADHD is a highly heterogeneous disorder, and separating out the different subgroups of genetic mutations that these children have is very important," said co-first author Josephine Elia, M.D., a child psychiatrist at Children's Hospital and an ADHD expert. She added that thousands of genes may contribute to the risk of ADHD, but that identifying a gene family responsible for 10 percent of cases is a robust finding in a common neuropsychiatric disorder such as ADHD. Overall, according to the CDC, 5.2 million U.S. children aged 3 to 17 have been diagnosed with ADHD.

Elia said the fact that their study identified gene variants involved in glutamate signaling is consistent with studies in animal models, pharmacology and brain imaging showing that these pathways are crucial in a subset of ADHD cases. She added, "This research will allow new therapies to be developed that are tailored to treating underlying causes of ADHD. This is another step toward individualizing treatment to a child's genetic profile."

Hakonarson expects this study will set the stage for further discoveries of ADHD-related genes along GMR signaling pathways. Moreover, the current research strongly suggests that selective GRM agonists could be
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. RECITAL Study Presents Excellent Outcomes and Rapid Patient Recovery With Revolutionary Femoral Access Procedure
2. Auxilium Pharmaceuticals, Inc. Announces First Patient Dosed in XIAFLEX® Study for Frozen Shoulder Syndrome
3. Ceregene Completes Enrollment of Second Phase 2 Study of CERE-120 for the Treatment of Parkinsons Disease
4. Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Combination Study of MM-121 and Multiple Anticancer Therapies in Patients with Advanced Solid Tumors
5. BioMarin Initiates Phase 2 Study for GALNS in Patients Under Five Years of Age With MPS IVA
6. New Study Points to Novel Mechanism by Which Tumors Escape Recognition by the Immune System
7. Inspiration Biopharmaceuticals Initiates Second Pivotal Clinical Study of Innovative Hemophilia Therapy OBI-1
8. Cara Therapeutics Initiates Phase I Study with Oral Formulation of Novel Peripherally-Acting Kappa Opioid Agonist
9. Updated Survival Data from Study Comparing TTF™ (Tumor Treating Fields) Therapy to Best Standard Chemotherapy for Recurrent Glioblastoma Reported at the 16th Annual Scientific Meeting of the Society for NeuroOncology
10. Perceptive Informatics® Global Survey Results Indicate Wide Use of Industry-Standard Medical Imaging Metrics to Meet Study Milestones
11. Merrimack Pharmaceuticals Initiates Enrollment in Phase 2 Study of MM-121 in Combination with Erlotinib in Three Groups of Patients with Non-Small Cell Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 21, 2014  Early symptoms of diabetic eye ... but new technology, coupled with yearly, comprehensive eye ... earlier detection of eye diseases, including those associated ... If left untreated, these diseases can potentially lead ... Recently, optometric researchers have deployed a new ...
(Date:10/22/2014)... Oct. 22, 2014 Sanomedics International Holdings, Inc. ... by Global Research & Data Services, demand for thermometers ... 2014 through 2018, as demand for more accurate digital ... is the world,s largest market for thermometers, and one ... is Sanomedics International Holdings, Inc. Sanomedics International ...
(Date:10/22/2014)... , Oct. 22, 2014  Recently published clinical ... bolstered the already substantial database of evidence. This data ... of Stretta therapy for sufferers of refractory ... clinical evidence supporting Stretta therapy as a safe ... that make Stretta therapy available to nearly 50 million ...
Breaking Medicine Technology:Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2Recent Clinical Study Data Confirms Efficacy of Stretta Therapy - Spurs Additional Insurance Coverage and Financing Round 2
... June 30, 2011 Xlumena, Inc., a ... and endoscopic surgeon, announced today that it has received ... The NAVIX is a multi-function system that enables exchange-free ... endoscopic pancreatic pseudocyst drainage.  The NAVIX will join the ...
... Cardica, Inc. (Nasdaq: CRDC ) today announced ... for its proprietary Microcutter XPRESS™ 30 surgical cutting and ... this product for commercial use in Europe. Cardica plans ... selected European centers starting in July. ...
Cached Medicine Technology:Xlumena Receives CE Mark for NAVIX™, Second Product to Enter European Market 2Cardica Applies CE Mark to Microcutter XPRESS™ 30 Surgical Cutting and Stapling Device 2Cardica Applies CE Mark to Microcutter XPRESS™ 30 Surgical Cutting and Stapling Device 3
(Date:10/22/2014)... Steven Reinberg HealthDay ... Infants who quickly add weight and length may be showing ... suggests. In adults, certain genes have been linked to ... proportionate gains in fat and lean muscle, the researchers said. ... heavier and taller. By ages 2 and 3, however, these ...
(Date:10/22/2014)... Tara Haelle HealthDay Reporter ... among young adult men may lead to increased blood pressure, ... cause a similar rise in blood pressure for young adult ... when young adult women drank lightly or moderately, their risk ... found. "This finding parallels studies in older adult men ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter , ... on Monday officially tightened guidelines for health workers treating Ebola ... and use of a respirator at all times. The ... the tougher rules after two Dallas nurses contracted Ebola while ... States, Liberian national Thomas Eric Duncan. Nina Pham is currently ...
(Date:10/20/2014)... October 20, 2014 With a mere ... Charlie Crist made a brief fundraising stop at the ... Thursday. , Fresh from a debate last night with ... the stage for the first seven minutes because Crist ... governor described the incident in one word: "weird." , ...
(Date:10/20/2014)... NY (PRWEB) October 20, 2014 ... non-profit organization that helps New Yorkers living with ... changes toward health, housing, recovery and self-sufficiency. Each ... transformed the local community through their tireless efforts. ... Marc Shapses , has been selected as ...
Breaking Medicine News(10 mins):Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 2Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 3
... million fine, CARMEL, Ind., May 7 ... settlement among state insurance regulators and two of,its ... Bankers Life and Casualty Company. The settlement concludes ... Texas and Florida related to long-term care claims ...
... - CEO John Cassin Brings 30 Years of Business Experience To Vail ... ... The Board of Directors of the Vail,Valley Medical Center announced today ... more than 30 years of healthcare,leadership experience to the Vail Valley Medical ...
... third language may have an unexpected advantage later in ... Knowing and speaking many languages may protect the brain ... a clinical neuro-psychologist from the Herczeg Institute on Aging ... Eyal, Aviva Shorek, and Jiska Cohen-Manfield, discovered recently that ...
... Following the impact of,Cyclone Nargis on Myanmar, which ... million more, Amnesty International is calling urgently,on the government ... aid is,provided on the basis of need without discrimination., ... lives, while some,donors are delaying aid in the fear ...
... NHS Choices ( http://www.nhs.uk ), the new,digital ... Live Well bundle aimed to,help people stay healthy ... accredited information, the Live Well Travel health guide,( ... seconds and provides them,with clinically approved guidance to ...
... Consumer,Healthcare, marketer of the leading smoking cessation products ... applauds,the release of the updated 2008 U.S. Public ... Dependence. Too many smokers lower their,chances of quitting ... The Guideline is an important validation of the ...
Cached Medicine News:Health News:Conseco Reaches Settlement of Multistate Market Conduct Examination 2Health News:Vail Valley Medical Center Board of Directors Announces Appointment of New President & CEO, John Cassin 2Health News:Tel Aviv University finds connection between mental fitness and multi-lingualism 2Health News:Myanmar Government Must Cooperate With International Community to Ensure Appropriate Aid for Victims, Urges Amnesty International 2Health News:A Statement from GlaxoSmithKline Consumer Healthcare on 2008 Update to the U.S. Public Health Service Guideline on Treating Tobacco Use and Dependence 2Health News:A Statement from GlaxoSmithKline Consumer Healthcare on 2008 Update to the U.S. Public Health Service Guideline on Treating Tobacco Use and Dependence 3
... The Auto Suture CONCORDE ... time the instrument handles are ... the skin and are then ... together. There are different staple ...
... Single Use Skin Staple Remover is ... design that is packaged 12 units ... remove skin staples. , ,The ... jaws of the extractor under the ...
... Single Use Articulating linear ... ,The Auto Suture™ ... and ROTICULATOR™ 55 single ... in abdominal, gynecological, pediatric ...
... Reloadable Linear Staplers deliver two staggered rows of ... They may be reloaded up to three times ... fire heavy wire staples for thick tissue. The ... interchangeable., ,Benefits include: , Parallel jaw closure ...
Medicine Products: