Navigation Links
New Gene Study of ADHD Points to Defects in Brain Signaling Pathways
Date:12/4/2011

PHILADELPHIA, Dec. 4, 2011 /PRNewswire-USNewswire/ -- Pediatric researchers analyzing genetic influences in attention-deficit/hyperactivity disorder (ADHD) have found alterations in specific genes involved in important brain signaling pathways. The study raises the possibility that drugs acting on those pathways might offer a new treatment option for patients with ADHD who have those gene variants—potentially, half a million U.S. children.

"At least 10 percent of the ADHD patients in our sample have these particular genetic variants," said study leader Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at The Children's Hospital of Philadelphia. "The genes involved affect neurotransmitter systems in the brain that have been implicated in ADHD, and we now have a genetic explanation for this link that applies to a subset of children with the disorder."

The study appears online today in Nature Genetics.

ADHD is a common but complex neuropsychiatric disorder, estimated to occur in as many as 7 percent of school-age children and in a smaller percentage of adults. There are different subtypes of ADHD, with symptoms such as short attention span, impulsive behavior and excessive activity. Its causes are unknown, but it tends to run in families and is thought to be influenced by many interacting genes. Drug treatment is not always effective, particularly in severe cases.

The study team did whole-genome analyses of 1,000 children with ADHD recruited at The Children's Hospital of Philadelphia, compared to 4,100 children without ADHD. The researchers searched for copy number variations (CNVs), which are deletions or duplications of DNA sequences. They then evaluated these initial findings in multiple independent cohorts that included nearly 2,500 cases with ADHD and 9,200 control subjects. All the study subjects were children of European ancestry.

Among those cohorts, the research team identified fo
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. RECITAL Study Presents Excellent Outcomes and Rapid Patient Recovery With Revolutionary Femoral Access Procedure
2. Auxilium Pharmaceuticals, Inc. Announces First Patient Dosed in XIAFLEX® Study for Frozen Shoulder Syndrome
3. Ceregene Completes Enrollment of Second Phase 2 Study of CERE-120 for the Treatment of Parkinsons Disease
4. Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Combination Study of MM-121 and Multiple Anticancer Therapies in Patients with Advanced Solid Tumors
5. BioMarin Initiates Phase 2 Study for GALNS in Patients Under Five Years of Age With MPS IVA
6. New Study Points to Novel Mechanism by Which Tumors Escape Recognition by the Immune System
7. Inspiration Biopharmaceuticals Initiates Second Pivotal Clinical Study of Innovative Hemophilia Therapy OBI-1
8. Cara Therapeutics Initiates Phase I Study with Oral Formulation of Novel Peripherally-Acting Kappa Opioid Agonist
9. Updated Survival Data from Study Comparing TTF™ (Tumor Treating Fields) Therapy to Best Standard Chemotherapy for Recurrent Glioblastoma Reported at the 16th Annual Scientific Meeting of the Society for NeuroOncology
10. Perceptive Informatics® Global Survey Results Indicate Wide Use of Industry-Standard Medical Imaging Metrics to Meet Study Milestones
11. Merrimack Pharmaceuticals Initiates Enrollment in Phase 2 Study of MM-121 in Combination with Erlotinib in Three Groups of Patients with Non-Small Cell Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... , Aug. 20, 2014 Reportbuyer.com has added ... Defibrillators Industry https://www.reportbuyer.com/product/98394/Global-Cardiac-Defibrillators-Industry.html ... in US$ Million by the following Product Segments: Implantable/Internal ... comprehensive analytics for the US, Canada ... , Asia-Pacific , ...
(Date:8/20/2014)... -- The National Necrotizing Fasciitis Foundation (NNFF) today announced that ... treated for a life threatening form of necrotizing fasciitis, or ... Medical Director of Inpatient Wound Care and founder of The ... Rancho Mirage, California . Dr. Gauto ... at Seton Hospital in Daly City, California ...
(Date:8/20/2014)... 20, 2014 Reportlinker.com announces that ... in its catalogue: Wireless Opportunities ... Zigbee, UWB WWAN, WMAN, WLAN and other ... Kalorama Information,s Wireless Opportunities in ... UWB WWAN, WMAN, WLAN and other technologies) ...
Breaking Medicine Technology:Global Cardiac Defibrillators Industry 2Global Cardiac Defibrillators Industry 3Global Cardiac Defibrillators Industry 4Global Cardiac Defibrillators Industry 5Global Cardiac Defibrillators Industry 6Global Cardiac Defibrillators Industry 7Global Cardiac Defibrillators Industry 8Global Cardiac Defibrillators Industry 9Global Cardiac Defibrillators Industry 10Global Cardiac Defibrillators Industry 11Global Cardiac Defibrillators Industry 12Global Cardiac Defibrillators Industry 13Global Cardiac Defibrillators Industry 14Global Cardiac Defibrillators Industry 15Global Cardiac Defibrillators Industry 16Global Cardiac Defibrillators Industry 17Global Cardiac Defibrillators Industry 18Global Cardiac Defibrillators Industry 19Global Cardiac Defibrillators Industry 20Rancho Mirage, California Physician Saves Casino Worker from Deadly 'Flesh Eating Disease' 2Rancho Mirage, California Physician Saves Casino Worker from Deadly 'Flesh Eating Disease' 3Rancho Mirage, California Physician Saves Casino Worker from Deadly 'Flesh Eating Disease' 4Rancho Mirage, California Physician Saves Casino Worker from Deadly 'Flesh Eating Disease' 5Rancho Mirage, California Physician Saves Casino Worker from Deadly 'Flesh Eating Disease' 6Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 2Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 3Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 4Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 5Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 6Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 7Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 8Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 9Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 10Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 11Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 12
(Date:8/21/2014)... Los Angeles, CA (PRWEB) August 21, 2014 ... sleep doctors across the U.S. This provides doctors with a ... Patients who find a doctor are that much closer to ... this condition have no idea they are experiencing this ... do not receive treatment at all. , Thanks to Sleep ...
(Date:8/21/2014)... found that the low-expression variant of fatty acid-binding ... Finns, reduces the risk of heart attack and ... to customise a potentially preventive drug for atherosclerosis. ... long-term research project of the Department of Neurology ... (HUS) focuses on carotid atherosclerosis. It is a ...
(Date:8/21/2014)... August 21, 2014 ... Peripheral Vascular Devices Market by Angioplasty ... Catheter (IVUS, OCT), IVC Filter (Retrievable), ... 2018" analyzes and studies the major ... the U.S. and Canada. , Browse ...
(Date:8/21/2014)... Minn. (PRWEB) August 21, 2014 ... social wellness solutions, announced today that it has entered ... medical best practices, mobile technology and predictive analytics for ... communities. , According to Michael Emerson , ... applied for two patents on the technology used in ...
(Date:8/21/2014)... Jupiter, FL (PRWEB) August 21, 2014 ... Ed Begley, Jr., scheduled to broadcast on Monday, August ... PST, via Discovery Channel. , In this episode, ... Park encourages social participation and improves human performance. Audiences ... social sustainability for public spaces by installing and providing ...
Breaking Medicine News(10 mins):Health News:Sleep Apnea Doctors US is Now Offering Complimentary Listings to Sleep Apnea Doctors Across the United States 2Health News:A novel pathway for prevention of heart attack and stroke 2Health News:North American Interventional Cardiology and Peripheral Vascular Devices Market worth $5.9 Billion by 2018 - Research Report by MarketsandMarkets 2Health News:North American Interventional Cardiology and Peripheral Vascular Devices Market worth $5.9 Billion by 2018 - Research Report by MarketsandMarkets 3Health News:North American Interventional Cardiology and Peripheral Vascular Devices Market worth $5.9 Billion by 2018 - Research Report by MarketsandMarkets 4Health News:North American Interventional Cardiology and Peripheral Vascular Devices Market worth $5.9 Billion by 2018 - Research Report by MarketsandMarkets 5Health News:Hunhu Healthcare Enters into Licensing Agreement with Mayo Clinic 2Health News:Announcing New Episode Airing of Innovations on Monday August 25, 2014 via Discovery Channel 2
... 9 (HealthDay News) -- Drinking light to moderate amounts ... both Alzheimer,s and some forms of age-related dementia, new ... abuse accounts for about 10 percent of all dementia ... to two drinks a day appears to protect ...
... study of a common etiquetteholding a door for someonesuggests that ... to reduce the work for those involved. The research, by ... University, is the first to combine two fields of study ... be published in a forthcoming issue of Psychological Science ...
... Maureen Salamon HealthDay Reporter , WEDNESDAY, March ... and family life, fueled by constant availability via cell ... women, a new study finds. Researchers from the ... American workers to determine gender differences in how men ...
... 9, 2011) University of Minnesota researchers are using salmonella ... of U.S. residents each year to do what was ... Center researchers believe salmonella may be a valuable tool in ... such as the liver, spleen, and colon since that,s ...
... 2011 Human social interactions are shaped by our ability ... some of the key features that enable us to identify ... gender, age, and body size, that lead to a unique ... neuroimaging research has already determined the various brain regions responsible ...
... process many more stimuli than we become aware of. Often ... being processed, but does not reach consciousness, that is, we ... the difference between conscious and unconscious perception, and can both ... important not only for basic research, but also for the ...
Cached Medicine News:Health News: A Little Alcohol May Stave Off Alzheimer's 2Health News:More reasons to be nice: It's less work for everyone 2Health News:Women Feel More Guilt, Distress About Work Intrusions at Home, Study Says 2Health News:Women Feel More Guilt, Distress About Work Intrusions at Home, Study Says 3Health News:U of M researchers using salmonella to fight cancer 2Health News:How do we combine faces and voices? 2Health News:Learning to see consciously 2Health News:Learning to see consciously 3
... Ad-Techs Model CMU Cortical Mapping Unit offers ... recording EEGs from exposed cortex during surgery. ... electrode plate can be positioned independently over ... provides two alternative mounting locations and each ...
... Selenia full field digital mammography system ... era in the world of mammography. ... combines the latest advances in digital ... capabilities to bring you the total ...
... The Stellate Harmonie workstation is a medical ... loads, high quality video capability, and archiving ... and review functions A framework that helps ... archiving of data A centralized database and ...
... features is the PupilFit software which automatically ... the pupil images, producing accurate, repeatable measurements ... circle is shown as a dotted line ... measurement ismeaningful, and not just a number ...
Medicine Products: