Navigation Links
New Gene Discovery Suggests Which Patients CTI's Brostallicin May Benefit
Date:4/13/2008

ertain drugs in an effort to discover cells' vulnerabilities (weak spots) and where the drugs are the strongest. With these data, investigators can target those patients with the highest probability of benefiting from a particular drug. By treating only the patients with the genetic characteristics known to react well to the drug, scientists may be able to decrease the time and money necessary to develop a drug and bring it to market. This approach also has the potential to improve the rate of treatment success and increase the number of approved drug products across the drug development industry.

About Brostallicin

Brostallicin, a novel synthetic second-generation DNA minor groove binder, has potent cancer killing activity and has demonstrated synergism in combination with standard cytotoxic agents as well as with newer targeted therapies in preclinical experimental tumor models. Brostallicin binds covalently to DNA within the DNA minor groove, interfering with DNA division and leading to tumor cell death. More than 200 patients have been treated with brostallicin in single-agent and combination studies. Brostallicin had predictable and predominantly hematologic toxicities. Activity was demonstrated in a number of solid tumor types. A phase II study of brostallicin in relapsed/refractory soft tissue sarcoma met its pre-defined activity and safety hurdles and resulted in a first-line phase II study that is currently being conducted by the European Organization for Research and Treatment of Cancer (EORTC).

About Systems Medicine (SM)

In July 2007, CTI acquired Systems Medicine (SM), a privately-held oncology company, in a stock-for-stock merger. SM applies a systems biology approach to drug development, combining pharmacogenomics and bioinformatics with experienced preclinical, clinical, and regulatory expertise to find and exploit a specific cancer's 'context of vulnerability.' Specifically, SM defines the molecular and genetic alteration
'/>"/>

SOURCE Systems Medicine LLC
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007
2. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722
3. Ono Enters into a New Fragment-Based Drug Discovery Agreement with Evotec
4. deCODE Launches a DNA-Based Test for Assessing Risk of Prostate Cancer on the Back of the Discovery of New Prostate Cancer Genes
5. FASgen Announces a New Discovery in Obesity Research
6. Orion Genomics Announces the Discovery of Novel Breast Cancer Biomarkers
7. Nobel Prize-Winning Discovery
8. FASgen Announces New Discovery for Treatment of Stroke
9. Ambrx Enters FGF-21 Type 2 Diabetes Drug Discovery Collaboration with Merck and Co. Inc.
10. Five Clinical Studies to Receive $2.5 Million Under Foundations 2007 Clinical Discovery Program
11. ARCA Discovery Announces Data Demonstrating Potential for Bucindolol as Targeted Therapy in Heart Failure, Atrial Fibrillation, and Ventricular Arrhythmia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... April 1, 2015  The first national study ... supplements to treat attention-deficit/hyperactivity disorder (ADHD) among children ... of children with ADHD were receiving behavioral therapy ... Control and Prevention (CDC) study, "Treatment of Attention-Deficit/Hyperactivity ... published today in The Journal of Pediatrics ...
(Date:4/1/2015)... 31, 2015 Research and Markets ... the "Metabolic Testing Market by Product (CPET, ... (Critical Care, Lifestyle Diseases), by Technology (REE, Body ... - Global Forecast to 2019 " report ... testing market is expected to reach $475.75 million ...
(Date:4/1/2015)... -- The fairness of the proposed acquisition of Auspex Pharmaceuticals ... ("Teva") is being investigated by WeissLaw LLP, a national ... on possible breaches of fiduciary duty and other violations ... for agreeing to sell the Company to Teva.  On ... for Teva to acquire ASPX in a transaction valued ...
Breaking Medicine Technology:CDC publishes first national study on use of behavioral therapy, medication and dietary supplements for ADHD in children 2CDC publishes first national study on use of behavioral therapy, medication and dietary supplements for ADHD in children 3CDC publishes first national study on use of behavioral therapy, medication and dietary supplements for ADHD in children 4Global Metabolic Testing (CPET, Body Composition Analysis, ECG, Portable System) Market 2015-2019 - REE, Body Composition Analysis for Gyms, Sports & Hospital 2WeissLaw LLP: Auspex Pharmaceuticals Inc. Acquisition By Teva Pharmaceutical Industries May Not Be In The Best Interest of ASPX Shareholders 2
... Neogen Corporation (Nasdaq: NEOG ) announces the ... Results WebcastWhen: , Thursday, September 23, 2010  @ 11:00 ... over the Internet -- Simply log on to the web ... Neogen Corporation, +1-800-234-5333.If you are unable to participate during the ...
... FORD, Pa., Sept. 22 Endo Pharmaceuticals (Nasdaq: ... U.S. Food and Drug Administration (FDA) that Endo,s new drug ... which is designed to be crush resistant, has been granted ... under the Prescription Drug User Fee Act (PDUFA) for Jan. ...
Cached Medicine Technology:
(Date:4/2/2015)... FL (PRWEB) April 02, 2015 As ... and Field gets its start! Runners have been putting ... ready to start racing. Zensah®, a premium compression apparel ... help ensure the athletes are benefiting from compression ... Zensah® is a Miami-based company, committed to using the ...
(Date:4/2/2015)... Oregon (PRWEB) April 02, 2015 ... sweeteners and custom sweetening solutions, recently announced the ... portfolio are Erysweet+ with stevia and Erysweet+ 100 ... and Stevia Blend fine powder, respectively. , Erysweet+ ... 95-60 and naturally fermented erythritol. It delivers a ...
(Date:4/1/2015)... BMA Management, a leader in assisted living ... to Gardant Management Solutions this spring. , “The name ... of our company and mirrors the optimistic, forward-looking focus ... we see,” said Rod Burkett, President and CEO of ... the company remains committed to providing a dignified, enriched ...
(Date:4/1/2015)... Royal River Natural Foods, a locally-owned independent natural ... found the amino acid creatine, which athletes typically use to ... pressure. , The report is part of the ... ,” which Royal River Natural Foods publishes each month as ... the latest in nutrition science. Also in the April issue, ...
(Date:4/1/2015)... panel session will look at the need for insurance ... that can grow in a privacy-friendly manner, thus preventing ... This topic has taken on even greater relevance in ... aren’t as secure as the automobile industry thought they ... Snapshot dongles contained very significant security flaws, which allowed ...
Breaking Medicine News(10 mins):Health News:Zensah® Partners With Austin Track Club 2Health News:Zensah® Partners With Austin Track Club 3Health News:Steviva Ingredients Announces Erysweet+ Rebrand 2Health News:New Study Finds Strength-Building Supplement Improves Circulation, Retailer Reports 2Health News:TU-Automotive: Office of The Privacy Commissioner of Canada To Set Out Privacy Considerations Surrounding UBI Products 2Health News:TU-Automotive: Office of The Privacy Commissioner of Canada To Set Out Privacy Considerations Surrounding UBI Products 3
... arthritic symptoms so severe that some victims can,t even walk. ... last up to a year., More than two million people ... Most of the infections have occurred in Southeast Asia, but ... likely because of global travel., With no vaccine available for ...
... Goodwin HealthDay Reporter , WEDNESDAY, April 27 (HealthDay News) ... U.S. population -- live in areas where the air is so ... says. Residents of Honolulu and Santa Fe-Espanola, N.M., on the ... is among the country,s cleanest -- and they were the only ...
... An experimental new drug that may treat hepatitis C more ... panel of experts for the U.S. Food and Drug Administration. ... be prescribed in combination with two existing drugs to help ... damage, according to documents posted by the FDA on its ...
... Serena Gordon HealthDay Reporter , TUESDAY, April 26 ... leaves the house, Nancy Geller worries about the food her ... allergy, and exposure to even a small amount of a ... "It,s a big worry, especially now that she,s a teenager ...
... cycles, known as circadian rhythms, are important for proper ... health. Disruptions of circadian rhythms and sleep-wake cycles have ... study by Douglas Institute researchers unravels a possible basis ... of clock genes in multiple areas of the human ...
... the context of rising levels of cardiovascular disease (CVD) in ... announces that for the first time- the Society will send ... of Cardiology (APCC). The 18th edition of the APCC ... to 8 May 2011. The ESC deputation will present an ...
Cached Medicine News:Health News:University of Houston wins NIH grant for vaccine study 2Health News:University of Houston wins NIH grant for vaccine study 3Health News:Report: California Cities Have Worst Air Pollution in U.S. 2Health News:Report: California Cities Have Worst Air Pollution in U.S. 3Health News:Report: California Cities Have Worst Air Pollution in U.S. 4Health News:Novel Hepatitis C Drug Holds Promise: FDA 2Health News:Anxiety's on the Menu for People With Food Allergies 2Health News:Anxiety's on the Menu for People With Food Allergies 3Health News:Researchers observe disruptions of daily rhythms in Alzheimer's patients' brains 2Health News:The European Society of Cardiology organizes educational program in Asia 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: