Navigation Links
New Gene Discovery Suggests Which Patients CTI's Brostallicin May Benefit
Date:4/13/2008

Cancer drug development guided by genomics

SAN DIEGO, April 14 /PRNewswire-FirstCall/ -- Systems Medicine LLC (SM), a wholly-owned subsidiary of Cell Therapeutics, Inc. (CTI) (Nasdaq and MTAX: CTIC), presented data from a preclinical study identifying the genetic markers in patients more likely to respond to treatment with the experimental drug, brostallicin, at the 2008 American Association for Cancer Research (AACR) annual meeting. These findings will be used to guide future development of brostallicin by suggesting which patients are most likely to respond when treated with brostallicin, potentially making the drug's development more efficient. This method of drug development is known as the context of vulnerability approach. The study was co-directed by Jeffrey A. Kiefer, Ph.D., and Holly Yin, Ph.D. in the Translational Genomics Research Institute's Pharmaceutical Genomics Division located in Scottsdale, Arizona.

"This study is an example of using a pharmacogenomic screening approach to find insights that guide the selection of specific contexts of vulnerability for brostallicin. These results provide information on which genetic characteristics to look for in determining whether or not a patient might benefit from treatment with brostallicin. In SM and CTI's continued efforts to make cancer more treatable, results like these broaden our knowledge of brostallicin's context of vulnerability, and bring us closer to being able to offer the right drug to each patient," said Jeffrey Jacob, CEO of SM.

In the study, the NCI-60 cell line panel was profiled for brostallicin response and correlated with specific genomic information derived from the cell line panel. The NCI-60 is a group of 59 human cancer cell lines derived from tumor tissue -- brain, blood and bone marrow, breast, colon, kidney, lung, ovary, prostate, and skin. Scientists often use cell lines, also called models, in preclinical studies in a laboratory setting. The
'/>"/>

SOURCE Systems Medicine LLC
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007
2. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722
3. Ono Enters into a New Fragment-Based Drug Discovery Agreement with Evotec
4. deCODE Launches a DNA-Based Test for Assessing Risk of Prostate Cancer on the Back of the Discovery of New Prostate Cancer Genes
5. FASgen Announces a New Discovery in Obesity Research
6. Orion Genomics Announces the Discovery of Novel Breast Cancer Biomarkers
7. Nobel Prize-Winning Discovery
8. FASgen Announces New Discovery for Treatment of Stroke
9. Ambrx Enters FGF-21 Type 2 Diabetes Drug Discovery Collaboration with Merck and Co. Inc.
10. Five Clinical Studies to Receive $2.5 Million Under Foundations 2007 Clinical Discovery Program
11. ARCA Discovery Announces Data Demonstrating Potential for Bucindolol as Targeted Therapy in Heart Failure, Atrial Fibrillation, and Ventricular Arrhythmia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2015)... 2015  IRIDEX Corporation (NASDAQ: IRIX ) today ... year 2014 financial results after the market closes on ... the Company will host a conference call with the investment ... Thursday, March 5, 2015 to discuss the results of ... may access the live conference call via telephone by dialing ...
(Date:2/26/2015)... 26, 2015 Legislation passed today by the ... to help prevent inappropriate prescriptions in Medicare Part D ... Integrity of Medicare Act (PIMA) of 2014 , introduced ... Brady (R-TX) and Ranking Member Jim McDermott (D-WA), ... epidemic and implement the right policies, said the Pharmaceutical ...
(Date:2/26/2015)... , Feb. 26, 2015 Research and Markets ... the "Radiation Therapy Equipment - Global Strategic Business ... This report analyzes the worldwide markets for Radiation Therapy ... Linear Accelerator, Treatment Planning Systems, and Radiation Therapy Simulator. ... Canada , Japan ...
Breaking Medicine Technology:IRIDEX Announces Fourth Quarter and Full Year 2014 Conference Call and Release Date 2PCMA Statement on the 'Protecting the Integrity of Medicare Act' 2Radiation Therapy Equipment - Global Strategic Business Report 2015-2020: Linear Accelerator, Treatment Planning Systems, and Radiation Therapy Simulator 2
... , SOMERVILLE, N.J. , Jan. ... has completed the acquisition of Acclarent, Inc., following clearance ... privately held medical technology company dedicated to designing, developing ... nose and throat (ENT). Ethicon announced its agreement ...
... Jan. 20 IDEXX Laboratories, Inc. (Nasdaq: IDXX ), ... results for Friday, January 29 , at approximately 7:00 a.m. ... 9:00 a.m. (eastern) on that day. , Individuals can access ... IDEXX Web site, www.idexx.com . An archived edition of the call ...
Cached Medicine Technology:IDEXX Laboratories to Release 2009 Fourth Quarter and Full-Year Financial Results 2
(Date:2/28/2015)... 28, 2015 My Shiney Hiney® LLC., the ... team to Las Vegas, Nevada for the annual ASD Market ... of the leading consumer-goods tradeshows and My Shiney Hiney will ... event. My Shiney Hiney can be found at booth number ... for the at-home personal hygiene brush and cleansing system exclusively ...
(Date:2/27/2015)... A new study published in the Journal ... cycle on a regular basis and prostate cancer. While cycling ... the more hours per week a man spends cycling, the ... an increased importance on prostate cancer screening methods. , “This ... closely at patents’ risk factors for developing prostate cancer,” says ...
(Date:2/27/2015)... Clinovo, a leading provider of cloud-based eClinical ... (EDC) at the CALBIO2015 conference taking place ... 3rd at Booth # 141. , ClinCapture ... edit-check builder allowing Clinical Trials Managers to create CRFs ... any programming experience. Clinovo’s new pricing model offers a ...
(Date:2/27/2015)... 2015 In New York City, a ... providing free dental care from his Sheepshead Bay­neighborhood practice. ... Dentistry from the Heart, and will be hosting a ... 50 patients who are in need of fillings, extractions, ... have access to high­quality service of Dr. Umanoff's practice ...
(Date:2/27/2015)... 2015 Dr. Andrew Campbell, one of ... pleased to announce the expansion of Quintessa Aesthetic Center ... Quintessa has begun seeing patients on February 18, 2015. ... will offer a variety of state-of-the-art surgical and ... micro laser peels, chemical peels, microdermabrasion, ProFractional Laser, Broad ...
Breaking Medicine News(10 mins):Health News:My Shiney Hiney® to Participate in ASD Market Week 2015 2Health News:Study Finds That Cycling Increases Risk For Prostate Cancer 2Health News:Study Finds That Cycling Increases Risk For Prostate Cancer 3Health News:Clinovo to Demo Its Self-Service, Cloud-Based EDC Solution at CALBIO2015 on March 2nd and 3rd, 2015 2Health News:Dr. Umanoff Unites with Dentistry from the Heart to Provide Community with Charitable Dental Care 2Health News:Dr. Umanoff Unites with Dentistry from the Heart to Provide Community with Charitable Dental Care 3Health News:Dr. Andrew Campbell Expands Quintessa Aesthetic Center into Delafield 2Health News:Dr. Andrew Campbell Expands Quintessa Aesthetic Center into Delafield 3
... yesterday in the lawsuit brought in Superior Court in ... during the,U.S. Medical Licensing Examination (USMLE). "Fairness to ... the,overriding concerns of the exam,s sponsors," said Joseph F. ... which co-sponsors the,exam and was named in the suit ...
... the September issue of the Journal of Periodontology (JOP) found ... plastic surgery than non-smokers. , The study followed 10 smokers ... of cigarette smoke on the long term outcomes of a ... of the teeth. After two years, residual gum recession ...
... symptoms may be mild, study finds , , TUESDAY, Sept. ... that tested positive for Gaucher disease, an inherited condition ... chose abortions, raising questions about the use of certain ... , The study authors also question the use of ...
... of Health (NIH) has awarded the University of Wisconsin-Madison,s new ... largest grants in the history of the UW School of ... an ambitious NIH plan to transform the country,s clinical and ... plan is to find ways to do a better job ...
... 3.0T Endorectal Coil for Prostate MR Now Available for All Three ... ... MEDRAD today announced the,availability of the 3.0T Prostate eCoil (TM) ... and Siemens. MEDRAD,introduced the 3.0T prostate eCoil for GE scanners in ...
... new grants will speed development of TB vaccines, diagnostic tests, ... drugs in support of the Global Plan ... & Melinda Gates,Foundation announced today grants totaling $280 million to ... earth and,kills nearly 2 million yearly - mostly in the ...
Cached Medicine News:Health News:Massachusetts State Court Hears Suit by Breastfeeding Mother on Medical Licensing Exam 2Health News:Study Questions Genetic Screening for Treatable Diseases 2Health News:Study Questions Genetic Screening for Treatable Diseases 3Health News:Major grant advances UW's clinical and translational research enterprise 2Health News:Major grant advances UW's clinical and translational research enterprise 3Health News:MEDRAD Announces eCoil(TM) for Siemens, Philips 3.0T MR Scanners 2Health News:MEDRAD Announces eCoil(TM) for Siemens, Philips 3.0T MR Scanners 3Health News:Gates Foundation Commits $280 Million for Research to Fight Global TB Epidemic 2Health News:Gates Foundation Commits $280 Million for Research to Fight Global TB Epidemic 3Health News:Gates Foundation Commits $280 Million for Research to Fight Global TB Epidemic 4
... is a versatile solution designed to optimize ... from preparation to diagnosis and therapy, for ... Artis dTC, your cath lab becomes an ... leaves you free to concentrate on what ...
The AXIOM Artis TC is ideal for applications above and beyond standard cardioangiography, and features:, Single plane C-Arm, ceiling-mounted, Full-size CCD camera, ...
... Artis BC is a biplane ... architecture ideal for cardiological diagnostics ... ergonomic architecture enables you to ... to focus on:, Interventional ...
The ACUSON Sequoia C512 system elevates imaging and Doppler performance through new, high-density acoustic sampling, precise control of the transmitted acoustic waveform, and new transducer technolog...
Medicine Products: