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New Fermented Soy Ingredient Containing S-equol Significantly Reduced Hot Flash Frequency
Date:1/4/2012

ducer status, based on results of a soy challenge test during the screening period. 

The trial used supplement tablets which each contained 5 mg of S-equol, and the trial participants took one tablet twice daily.  SE5-OH is the product of fermentation of soy germ by the bacterial strain Lactococcus 20-92 using a patented and proprietary process by the Otsuka Pharmaceutical Co., Ltd.  The process results in the conversion of the daidzein to S-equol.  SE5-OH is created under current Good Manufacturing Practices.  Following fermentation, the bacteria undergo heat denaturation and are deactivated.  The process is designed to produce a S-equol-rich product, or nutraceutical ingredient.  The ingredient has self-affirmed GRAS (Generally Recognized As Safe) status.  Development and ongoing research of SE5-OH containing S-equol is conducted by the Saga Nutraceuticals Research Institute of Otsuka Pharmaceutical Co., Ltd.  Pharmavite, a subsidiary of Otsuka, is studying SE5-OH containing S-equol as a dietary supplement for the management of menopausal symptoms.

Otsuka Pharmaceutical Co. Ltd. supported the study. The study data were presented in an oral presentation at the North American Menopause Society annual meeting in October 2009.

Preliminary evidence from other, observational studies suggests that Japanese women who produce S-equol naturally may have fewer menopausal symptoms.  Controlled clinical trials have documented that SE5-OH containing S-equol reduces the frequency of hot flashes as well as muscle discomfort associated with menopause, both in women in Japan and the United States. 

S-equol binds to the same estrogen receptors as naturally occurring estrogen, but with a stronger affinity for the estrogen beta receptor.  On binding to these receptors, S-equol mimics some, but not all, activities of estrogen.&#
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SOURCE Pharmavite LLC
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