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New Fermented Soy Ingredient Containing S-equol Significantly Reduced Hot Flash Frequency
Date:1/4/2012

2), as measured by the Climacteric Symptom Evaluation Form Checklist, which measured the severity of 22 menopausal symptoms as well as the hot flash frequency. The women recorded the severity of their menopausal symptoms in a diary at the study start, and at the end of the treatment (week 12) using a four-point scale (0: none, 1: mild, 2: moderate and 3: severe). A decrease in a symptom score of one or more points was classified as an improvement.

The women receiving SE5-OH with S-equol had significant improvements in the severity of their neck or shoulder muscle stiffness scores compared to those in the placebo group (P=0.004).  Of note, women in Japan in general experience fewer hot flashes but experience more neck and shoulder stiffness than women in the United States.

The severity of hot flashes, sweating, sleeplessness, depression, and neck or shoulder muscle stiffness, were measured by the validated assessment tool, the Visual Analog Scale(VAS).  The VAS indicated a significant decrease in neck and shoulder stiffness for women receiving SE5-OH with S-equol compared to those in the placebo group (-11.9 +/- 26.7 mm vs. -1.6 +/- 17.1 mm, P=0.007).  Also, scores on the sub-scales of the Greene Climacteric Scale revealed a significant difference on the somatic subscale in the SE5-OH group compared to the placebo group (P=0.043) and a strong positive trend on the vasomotor subscale score the SE5-OH group, compared to the placebo group (P=0.052).  The women also rated their quality of life using a standardized Short Form 36 Health Survey, its general health perception scale scoring trended positively toward improvement in the SE5-OH containing S-equol group compared to the placebo group (P=0.090).

The trial also evaluated safety and adverse treatment-related effects.  No adverse events were reported in this study and the supplement was well tolerated.  The use of SE5-OH containing S-equol
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