NORTHRIDGE, Calif., Jan. 4, 2012 /PRNewswire-USNewswire/ -- Daily doses of a soy germ-based nutritional supplement containing S-equol significantly improved menopausal symptoms, including significantly reducing hot flash frequency after 12 weeks according to a placebo-controlled study in postmenopausal Japanese women published in the peer-reviewed Journal of Women's Health.

"It is believed that S-equol, produced from the isoflavone daidzein during the fermentation of soy germ, interacts with specific estrogen receptors to promote the improvement in menopausal symptoms.  Data from this study and other clinical studies, including those done in U.S. women, shows that the supplement SE5-OH containing S-equol may serve as a promising alternative for reducing the frequency of hot flashes and perhaps other menopausal symptoms," said Belinda H. Jenks, Ph.D., director of Scientific Affairs & Nutrition Education at Pharmavite LLC, the makers of NatureMade^® vitamins and minerals.

In the double-blind, randomized study, the daily frequency of the women's hot flashes after 12 weeks of treatment decreased by 58.7 percent (-1.9 +/- 1.8 daily compared to 3.2 +/- 2.4 daily at the study start) for the 66 women receiving a daily dose of 10 milligrams (mg) of S-equol contained in SE5-OH , significantly more than the 34.5 percent reduction (-1.0 +/- 2.0 daily vs. 2.9 +/- 2.1 daily at study start) experienced by the 60 women receiving a placebo (P=0.009).  Of the 34 women who enrolled with at least three hot flashes daily, the women receiving SE5-OH had a 62.8 percent reduction in their daily hot flash frequency (-2.9 +/- 2.0), significantly greater than 23.6 percent reduction experienced by the 28 women in the placebo group (-1.2 +/- 2.9) (P=0.009).   

Moreover, the women in the SE5-OH with S-equol group experienced significant decreases in the severity of their hot flashes (P=0.01
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