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New England Journal of Medicine Publishes Results From a RELISTOR Phase 3 Clinical Study
Date:5/28/2008

Study Demonstrated Efficacy of RELISTOR for Use in Advanced-Illness

Patients with Opioid-Induced Constipation

COLLEGEVILLE, Pa. and TARRYTOWN, N.Y., May 28 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), and Progenics Pharmaceuticals, Inc. (Nasdaq: PGNX) today announced the publication of results from a pivotal phase 3 trial of RELISTOR(TM) (methylnaltrexone bromide) subcutaneous injection in the May 29, 2008 issue of the New England Journal of Medicine. RELISTOR is a newly approved therapy for the treatment of opioid-induced constipation (OIC) in patients with advanced illness who are receiving palliative care, when response to laxative therapy has not been sufficient.

The clinical study showed that significantly more OIC patients with advanced illness experienced bowel movements (laxation) within four hours of receiving their first dose of subcutaneous RELISTOR than patients receiving placebo, without the use of a rescue laxative (48 percent vs. 15 percent; P<0.001). The study also demonstrated that RELISTOR did not impair the ability of opioids to provide pain relief, and the drug was generally well tolerated.

"Effectively managing pain is critical for patients with advanced illness," says Jay Thomas, M.D., Ph.D., a lead author of the study and Clinical Medical Director of The San Diego Hospice and the Institute for Palliative Medicine. "However, the side effects associated with many pain medications can represent a significant barrier to prov
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SOURCE Wyeth Pharmaceuticals
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