Navigation Links
New Drugs May Improve Quality of Life for People with Parkinson's Disease
Date:3/14/2013

SAN DIEGO, March 14, 2013 /PRNewswire-USNewswire/ -- Three studies released today present possible positive news for people with Parkinson's disease. The studies, which will be presented at the American Academy of Neurology's 65th Annual Meeting in San Diego, March 16 to 23, 2013, report on treatments for blood pressure problems, the wearing-off that can occur when people have taken the main drug for Parkinson's for a long time, and for people early in the disease whose symptoms are not well-controlled by their main drugs.

"All of these treatments are promising news for people with Parkinson's disease, which is the second most common neurodegenerative disease after Alzheimer's disease," said Robert A. Hauser , MD, MBA, of the University of South Florida in Tampa and a Fellow of the American Academy of Neurology, who was an author of all three studies.

The first study dealt with the rapid drop in blood pressure that people with Parkinson's can experience when standing up, which can lead to dizziness, fainting and falls. The problem, which affects about 18 percent of people with the disease, occurs because the autonomic nervous system fails to respond to changes in posture by releasing enough of the chemical norepinephrine.

In the study, 225 people were randomized to receive either eight weeks of stable dose treatment with a placebo or the drug droxidopa, which converts to norepinephrine. After one week of stable treatment, those who received the drug had a clinically meaningful, two-fold decrease in the symptoms of dizziness and lightheadedness, when compared to placebo. They also had fewer falls, or 0.38 falls per patient per week, compared to 1.73 for those receiving a placebo on average over the entire 10-week study duration.

The second study looked at treatment with a new drug for "wearing-off" that occurs with people who have been taking levodopa for several years. As each dose wears off, people experience longer periods of time where the motor symptoms do not respond to levodopa. For the study, 420 people who were experiencing an average of six hours of "off" time per day received a placebo or one of four dosages of the drug tozadenant in addition to their levodopa for 12 weeks. People receiving two of the dosages of the drug had slightly more than an hour less off time per day at the end of 12 weeks than they had at the start of the study. They also did not have more troublesome involuntary movements during their "on" time, called dyskinesia, that can occur.

The third study looked at 321 people with early Parkinson's disease whose symptoms were not well-controlled by a dopamine agonist drug. For the 18-week study, the participants took either the drug rasagiline or a placebo in addition to their dopamine agonist. At the end of the study, those taking rasagiline had improved by 2.4 points on a Parkinson's disease rating scale. In addition, rasagiline was well tolerated with adverse events similar to placebo.

The blood pressure study was supported by Chelsea Therapeutics. The "wearing-off" study was supported by Biotie Therapies, Inc., The early Parkinson's disease study was supported by Teva Pharmaceuticals.

Learn more about Parkinson's disease at http://www.aan.com/patients.

The American Academy of Neurology, an association of more than 25,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer's disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson's disease and epilepsy.

For more information about the American Academy of Neurology, visit http://www.aan.com or find us on Facebook, Twitter, Google+ and YouTube.


'/>"/>
SOURCE American Academy of Neurology
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Ophthalmic Drugs: World Market Prospects 2012-2022
2. Antithrombotic/Anticoagulant Drugs: World Market 2012-2022
3. INTAC™ Technology Combats Misuse of Extended Release Drugs
4. Contract Research Organizations Set to Experience Rapid Growth as Development Costs for New Drugs Continue to Rise
5. Cell Therapeutics Aequus BioPharma Validates its Proprietary GlycoPolymer Technology for the Extension of the Half-life of Therapeutic Protein Drugs
6. Bilcare and CSIR to Partner on nonClonableID Technology for Authentication of Drugs
7. Frost & Sullivan: Launch of New Classes of Oral Antidiabetic Drugs by 2014 will Uplift Prospects for the European Diabetes Therapeutics Market
8. Genitourinary Drugs: Technologies and Global Markets
9. Pricing and Reimbursement in Russia - Big Pharma Take Advantage of Reimbursement for Costly Drugs Through the DLOs Seven Nosologies Program
10. Partnership Aims to Prevent Students from Misusing Prescription Drugs
11. Global Kidney Cancer Drugs Industry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... -- According to the new market ... by Components (Software, Service), Delivery Modes (Web-based, On-premises, ... Companies, Clinical Research Organization, Medical Device Companies) Global ... 2022", published by Scalar Market Research, the global ... to grow at a healthy CAGR of 14.30% ...
(Date:12/7/2016)... Dec. 7, 2016   TraceLink Inc ., ... connecting the Life Sciences supply chain and eliminating ... announced that Tjoapack has selected TraceLink,s serialization solutions ... comply with the rapidly approaching serialization deadlines for ... in 2017 and the EU Falsified Medicines Directive ...
(Date:12/7/2016)... Dec. 7, 2016  Varian Medical Systems (NYSE: ... previously announced plans to separate its Imaging Components business.  ... tax-free distribution to Varian stockholders of common stock in ... will hold the Imaging Components business.  As part of ... by the end of January 2017, Varian will receive ...
Breaking Medicine Technology:
(Date:12/7/2016)... ... December 07, 2016 , ... Castle Dermatology Institute is ... ways to restore a more youthful appearance to the face. Dr. Peyman Ghasri and ... with a variety of other treatments, to rejuvenate and renew the facial appearance. ...
(Date:12/7/2016)... MA (PRWEB) , ... December 07, 2016 , ... They ... They are sisters and wives, brothers and fathers, from New England and around the ... and its stigma, and are brought together in a beautiful and compelling new photographic ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... consultation services from offices located in South Lyon, Dewitt, Williamston, East Lansing, Ann ... basketball coach who needs treatment for a brain tumor. , Jason Bauer and ...
(Date:12/7/2016)... ... ... One of two inventors from Glen Burnie, Md., has a granddaughter who uses ... why the co-inventor and I have designed a new and better way to secure ... the patent-pending AV-AIR, a device that serves as an alternative to conventional methods of ...
(Date:12/7/2016)... AUSTIN, TX (PRWEB) , ... OCTOBER XX, 2016 ... ... may help solve another mystery. A new study entitled “Canine Filamentous Dermatitis ... Morgellons disease can occur in dogs. The study was published in the prestigious ...
Breaking Medicine News(10 mins):