Navigation Links
New Drug Application for Ibrutinib Submitted to the U.S. FDA
Date:7/10/2013

nt.

In CLL, the genetic mutation del 17p occurs when the short arm of chromosome 17 is missing. Del 17p CLL is associated with abnormalities of a key tumor suppressor gene, TP53, which results in poor response to chemoimmunotherapy and worse treatment outcomes. It occurs in about seven percent of treatment naïve CLL patients, with approximately 20-40 percent of relapsed/refractory patients harboring the mutation.

About Mantle Cell Lymphoma
MCL is a B-cell malignancy, an aggressive type of B-cell non-Hodgkin lymphoma (NHL) that usually occurs in older adults.2 The disease typically begins in the lymph nodes, but can spread to other tissues, such as bone marrow, liver, and spleen3. Patients typically survive an average of five years.4 In the U.S., there are approximately 5,000 new cases of MCL each year.3

About Ibrutinib
Ibrutinib is an investigational agent designed to provide potent and sustained inhibition of an enzyme called Bruton's tyrosine kinase (BTK). BTK is a key mediator of at least three critical B-cell pro-survival mechanisms occurring in parallel – regulation of apoptosis, adhesion, and cell migration and homing. Through these multiple signals, BTK regulation helps to direct malignant B-cells to lymphoid tissues, thus allowing access to a micro-environment necessary for survival.

The effectiveness of ibrutinib alone or in combination with other treatments is being studied in several B-cell malignancies, including chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Waldenström's macroglobulinemia and multiple myeloma. To date, 7 Phase III trials have been initiated with ibrutinib and a total of 31 trials are currently registered on www.clinicaltrials.gov. Janssen and Pharmacyclics entered a collaboration and license agreement in '/>"/>

SOURCE Pharmacyclics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Zogenix Submits New Drug Application (NDA) to U.S. Food and Drug Administration (FDA) for Zohydro™ for Treatment of Chronic Pain
2. Ventana Receives FDA Clearance for p53 (DO-7) Image Analysis and Digital Read Applications
3. Bio-AMD, Inc.; Patent Application for Cartridge Test Cap
4. Global Ablation Technologies Market (2011-2016) - By Application and Devices in Radiofrequency, Cryoablation, Microwave, Ultrasound, Hydrothermal, Radiation, Electrical, Light/Laser and Hydromechanical - Global Trends & Competitive Analysis
5. Rubicon Genomics Launches ThruPLEX™ Family of Sample Preparation Products for Next Generation Sequencing Applications
6. Ambit Biosciences and Teva Announce Clearance of an Investigational New Drug (IND) Application for CEP-32496, A Novel BRAF(V600E) Inhibitor
7. CSL Behring Announces FDA Filing of Biologics License Application for 4-Factor PCC for Urgent Reversal of Vitamin K Antagonist Anticoagulant Therapy
8. Janssen Research & Development Submits New Drug Application to U.S. FDA for Canagliflozin to Treat Patients with Type 2 Diabetes
9. Philips demonstrates innovations in nuclear medicine imaging with a comprehensive portfolio of NM applications for IntelliSpace Portal
10. Clinical Safety Data for ChromaDex®s Patented pTeroPure® (pterostilbene) Released at 6th World Congress on Polyphenols Applications in Paris
11. UltraTape announces Cleanroom Labels for Cryogenic Laboratory applications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... 2014 Today, the Obama Administration issued ... "accommodation" but still require religious organizations to facilitate ... effect, including Plan B (the "morning after pill") ... Administration also announced that it is investigating expanding ... The regulations issued today keep the ...
(Date:8/22/2014)... , Aug. 22, 2014  Dr. Mark ... with the Diamond Lifetime Achievement Award in the field ... CEO of Cardiovascular Clinical Associates. Dr. Rasak ... managing all major aspects of the business; overseeing the ... as primary coronary intervention. In addition, he is an ...
(Date:8/22/2014)... LA JOLLA , Cali ., Aug. ... Annual International Papillomavirus Conference shows that a therapy being developed ... including the two that cause 70 percent of all cervical ... models, HTI-1968 blocked the replication of HPV-16, HPV-18 and HPV-11 ... Thomas Broker , Ph.D., who presented the findings at ...
Breaking Medicine Technology:Liberty Institute: Government "Accommodation" Still Requires Employers To Facilitate Coverage Of Abortifacient Drugs 2Dr. Mark Rasak, MD is recognized by Continental Who's Who with the Diamond Lifetime Achievement Award 2Study shows Hera Therapeutics experimental compound shuts down human papillomavirus that causes most cervical cancer 2
... In the USA, each state is responsible for its Women ... the purchase of supplies. A state bid notification for breastpumps ... unusual feature that needs further attention. The bid,s breastpump requirement ... of the women. The state felt that it was acceptable ...
... Reportlinker.com announces that a new market research ... Reportlinker Adds Chugai Pharmaceutical Co. ... http://www.reportlinker.com/p0155101/Reportlinker-Adds-Chugai-Pharmaceutical-Co-Ltd-PharmaVitae-Profile.html , Introduction , ... performance for Chugai in the prescription pharmaceutical ...
Cached Medicine Technology:Do Women Have a Right to a Breastpump That Works? Asks Hygeia 2Reportlinker Adds Chugai Pharmaceutical Co. Ltd: PharmaVitae Profile 2Reportlinker Adds Chugai Pharmaceutical Co. Ltd: PharmaVitae Profile 3Reportlinker Adds Chugai Pharmaceutical Co. Ltd: PharmaVitae Profile 4Reportlinker Adds Chugai Pharmaceutical Co. Ltd: PharmaVitae Profile 5Reportlinker Adds Chugai Pharmaceutical Co. Ltd: PharmaVitae Profile 6Reportlinker Adds Chugai Pharmaceutical Co. Ltd: PharmaVitae Profile 7
(Date:8/22/2014)... (PRWEB) August 22, 2014 Japantown Dental ... a new teeth whitening technique. Air polishing is a ... appointments. , Dark teeth can be caused by a ... external stains and internal stains. External stains include coffee, ... be caused by certain medications, such as tetracycline, and ...
(Date:8/22/2014)... Princeton, Indiana (PRWEB) August 22, 2014 ... because Toyota Indiana is on the grow ... add 300 jobs by summer 2016 to boost production ... expansion will bring Toyota Indiana’s overall investment to $4 ... in North America while providing additional flexibility to adjust ...
(Date:8/22/2014)... LSU Health New Orleans School of Nursing was ... to increase access to advanced nursing education and ... as well as veterans. The Health Resources and ... and Human Services awarded the two-year grant. Scharalda ... project director., The Advanced Education Nursing Traineeship (AENT) ...
(Date:8/22/2014)... Millennium Treatment Group, a drug ... recently launched a new website. Patients, parents, loved ... now find Millennium Treatment Group at http://www.millenniumtreatmentgroup.com ... at the beginning of July. Everything anyone would ... found on the website. There’s an About Us ...
(Date:8/22/2014)... August 22, 2014 Mi40x , the ... research to show people how they can use a simple ... only a matter of weeks has caught the attention of ... is one of the most well-known bodybuilders in the industry, ... he has today, that in itself is a testament to ...
Breaking Medicine News(10 mins):Health News:Japantown Dental Introduces Air Polishing 2Health News:Toyota Indiana Adding 300 Jobs to Build More Highlanders 2Health News:Millennium Treatment Group Has a New Website 2Health News:Mi40x: Review Exposes Ben Pakulski’s Guide to Packing on Lean Muscle Fast 2
... 20 A team of medical,professionals from the ... services in Germany impressive. The NRH team has ... the US Army,s Europe Regional,Medical Command (ERMC) in ... and capability of our military health care system ...
... life of adolescents who think they are too fat ... This was a result of the all Germany Health ... of the Robert Koch Institute, as presented by Brbel-Maria ... Deutsches rzteblatt International (Dtsch Arztebl Int 2008, ...
... Symmetry Medical Inc.,(NYSE: SMA ), a leading ... and other medical markets, announced today that,it will release ... 2008 before the market opens on Tuesday, June 24, ... 8:00 a.m. ET on,Tuesday, June 24., A live ...
... 20 Women in Ireland will,soon be able ... by,Quest Diagnostics Incorporated (NYSE: DGX ), the ... with the Irish,National Cancer Screening Service (NCSS), Quest ... medical outcomes and,reduce anxiety wait time for women ...
... Hearing, TORONTO, June 20 /PRNewswire-FirstCall/ - Predictive ... announced the successful completion,of its agreement with one ... result of the completion of this project, PreMD ... for further product development and,other skin testing initiatives., ...
... Put Millions at Risk, SAN FRANCISCO, June 20 ... theft epidemic by making it easy for,people with access ... using,stolen information. Hospital workers, lab technicians and even janitors,with ... able to manipulate,the automated systems used by such industry ...
Cached Medicine News:Health News:National Rehabilitation Hospital Team Calls Work of US Army's Europe Regional Medical Command Impressive 2Health News:National Rehabilitation Hospital Team Calls Work of US Army's Europe Regional Medical Command Impressive 3Health News:National Rehabilitation Hospital Team Calls Work of US Army's Europe Regional Medical Command Impressive 4Health News:'Feeling fat' is worse than being it 2Health News:Symmetry Medical to Report First Quarter 2008 Financial Results on June 24, 2008 2Health News:Quest Diagnostics to Provide Diagnostic Testing Services for the Women of Ireland through Ireland's First Nationwide Cervical-Cancer Screening Program 2Health News:Quest Diagnostics to Provide Diagnostic Testing Services for the Women of Ireland through Ireland's First Nationwide Cervical-Cancer Screening Program 3Health News:Quest Diagnostics to Provide Diagnostic Testing Services for the Women of Ireland through Ireland's First Nationwide Cervical-Cancer Screening Program 4Health News:PreMD Successfully Completes Project for Health & Beauty Company 2Health News:Credit Card Companies Fueling Healthcare Associated Identity Theft (HAIT) Crimes 2
Ergotec Vetriretinal Instrument System. Reverse action jaws. 0.4 mm cupped tips....
Designed for peeling delicate epiretinal membrane in cases of premacular fibroplasia. Positive action closure. Barrel design with straight 20 gauge 40 gauge long shaft. 1 x 1.5 mm lightly serrated ja...
Triangular shaped tips. Marked for 5 mm and 10 mm tucks. Round knurled handle with polished finish....
Angled shafts with 9 mm scaled jaws. 1 mm teeth on one jaw fit into holes on the other jaw. Slide lock and serrated handle with polished finish. Left....
Medicine Products: