In the study, bile acid tracers were given to the men after they had eaten their evening meal. The researchers then recorded blood samples at 13, 17.5, 24, 37, 46, 63, 70 and 91 hours after the bile acid tracers were administered. No differences between the two groups were observed for cholic acid (CA) or the chenodeoxycholic acid (CDCA) pool sizes, CDCA synthesis rate, or bile acid fractional turnover rates.
However, compared to the healthy cohort (HC), the men with type 2 diabetes showed a significantly higher CA synthesis rate (15.9 plus or minus 3.1 vs. HC 9.5 plus or minus 3.2 micro mol/kg/d; p<0.01), DCA input rate (9.0 plus or minus 1.5 vs. HC 4.9 plus or minus 2.4 micro mol/kg/d; p<0.01), DCA pool size (21.4 plus or minus 6.5 vs. HC 13.7 plus or minus 6.3 micro mol/kg; p<0.05) and total bile acid synthesis (28.1 plus or minus 6.7 vs. HC 18.5 plus or minus 6.4 micro mol/kg; p<0.05). The researchers concluded that these changes in bile acid metabolism may contribute to altered glucose, fat, and energy metabolism in patients with type 2 diabetes.
About KineMarker(TM) Technology
KineMed's KineMarker technology is designed to quickly demonstrate,
preclinically and clinically, whether compounds are "on mechanism" or are
acting upon specific metabolic pathways that are the basis for particular
diseases. KineMed's technology measures the kinetics of these pathways
using a stable isotope labeling te
|SOURCE KineMed, Inc.|
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