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New Discovery of Key Difference in Bile Acid Metabolism in Patients with Type 2 Diabetes May Suggest Underlying Disorder
Date:6/9/2008

e administering any interventions, researchers recorded baseline values of bile acids in nine men with type 2 diabetes and in 12 healthy men. The men ranged in age from 42 to 56 years old and were also matched for body mass index. From study outset, those subjects with type 2 diabetes had significantly higher blood glucose levels, as measured by A1C (A1C gives a reading of the average blood glucose levels for the past two to three months). The men with type 2 diabetes also had significantly higher fasting glucose as well as triglyceride levels.

In the study, bile acid tracers were given to the men after they had eaten their evening meal. The researchers then recorded blood samples at 13, 17.5, 24, 37, 46, 63, 70 and 91 hours after the bile acid tracers were administered. No differences between the two groups were observed for cholic acid (CA) or the chenodeoxycholic acid (CDCA) pool sizes, CDCA synthesis rate, or bile acid fractional turnover rates.

However, compared to the healthy cohort (HC), the men with type 2 diabetes showed a significantly higher CA synthesis rate (15.9 plus or minus 3.1 vs. HC 9.5 plus or minus 3.2 micro mol/kg/d; p<0.01), DCA input rate (9.0 plus or minus 1.5 vs. HC 4.9 plus or minus 2.4 micro mol/kg/d; p<0.01), DCA pool size (21.4 plus or minus 6.5 vs. HC 13.7 plus or minus 6.3 micro mol/kg; p<0.05) and total bile acid synthesis (28.1 plus or minus 6.7 vs. HC 18.5 plus or minus 6.4 micro mol/kg; p<0.05). The researchers concluded that these changes in bile acid metabolism may contribute to altered glucose, fat, and energy metabolism in patients with type 2 diabetes.

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