Navigation Links
New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study
Date:6/7/2008

Results Presented at the ADA's Annual Scientific Sessions

SAN FRANCISCO, June 7 /PRNewswire-FirstCall/ -- Sanofi-aventis announced today that the results of the dose-finding study for its new injectable diabetes compound AVE0010, a GLP-1 agonist, were presented at the American Diabetes Association's (ADA) 68th Annual Scientific Sessions meeting in San Francisco, California.

The study found that AVE0010 was well tolerated and significantly improved glycemic control versus placebo in type 2 diabetes patients inadequately controlled with metformin alone. The once daily regimen demonstrated a clear dose response with a similar HbA1c reduction to twice daily regimen. AVE0010 was also found to be associated with weight loss and reductions in postprandial glucose.

"The results of the once daily AVE0010 regimen are very promising and this new GLP-1 agonist has a potential to become an important addition to the treatment armamentarium for type 2 diabetes," said Robert Ratner, from the MedStar Research Institute Washington DC, Principal Investigator of the dose-finding study.

About the Study

The dose-finding study involved 542 type 2 diabetes patients inadequately controlled on metformin monotherapy (1.6-1.9 g/day). In this double-blind study, patients were randomized to receive for 13 weeks, either AVE0010 subcutaneously at the doses of 5, 10, 20 and 30 micron(g) once daily or twice daily, or placebo. The primary endpoint was change in HbA1c from baseline. Secondary endpoints included weight change and 2-hour post-prandial plasma glucose (PPG).

Baseline characteristics were similar among groups in terms of mean age (56 +/-9 years), diabetes duration (6.6 +/-5 years), HbA1c (7.5 +/-0.6%) and Body Mass Index (31.9 +/-4 kg/m2). Despite mildly elevated baseline HbA1c, the results of the study demonstrated a highly statistically significant dose response with a net decrease in mean HbA1c from baseline subtracted from placebo f
'/>"/>

SOURCE sanofi-aventis
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Monotherapy BYETTA(R) (exenatide) Injection Study Results Presented at ADA 2008 Showed Adults with Type 2 Diabetes Experienced Improved Glycemic Control and Weight Loss
2. DURABLE Clinical Trial Results Show GlycoMark is Key Test for Managing Patients with Diabetes
3. Study Shows Lantus(R) Helped People Living with Type 2 Diabetes Reach the ADAs Recommended Target for Blood Sugar Control
4. The Largest Ever Study of Diabetes Shows Intensive Glucose Control Reduces Serious Complications
5. International Diabetes Federation Grant Supports Lifestyle Intervention Study to Prevent Type 2 Diabetes in India
6. Naturally Occurring Compounds in Cocoa Tied to Blood Flow Improvements for Adults With Type 2 Diabetes
7. Blood Spot Technology at ZRT Highlighted in March Issue of Journal of Diabetes Science & Technology - A Convenient Alternative to Serum Testing for Health Screening
8. Continued Funding to Help Advance Exciting Moment in Diabetes Research
9. CureDMs Diabetes Therapy Achieves Major Development Milestone
10. Drug Combo Could Lower Diabetes Complications and Costs
11. Discovery Leads to Earlier Diagnosis of Type 1 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... SAN DIEGO , July 30, 2014  Eisai Inc. ... today that an article based on post-hoc analyses from the ... Loss While on Lorcaserin, Diet, and Exercise as a Predictor ... online issue of Obesity , the official peer reviewed ... was to identify whether there is an early treatment milestone ...
(Date:7/30/2014)... NEW YORK , July 30, 2014 /PRNewswire/ ... new products for oncology supportive care, announced that its ... been featured in an article on OncLive.com titled, "Study ... and Neck Cancers."  Dr. Steve Sonis , a ... growing demand seen in the oncology community for evidence-based ...
(Date:7/30/2014)... July 30, 2014 /PRNewswire-iReach/ -- This is a ... Chinese Heparin sodium (CAS 9041-08-1) & calcium (CAS ... information of Heparin sodium (CAS 9041-08-1) & calcium ... technology. The report then explores global and China,s ... calcium (CAS 37270-89-6) listing their product specification, capacity, ...
Breaking Medicine Technology:Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 2Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 3Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 4Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 5Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 6Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 7Access Pharmaceuticals Featured On OncLive.com 2Access Pharmaceuticals Featured On OncLive.com 3Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 2Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 3Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 4Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 5
... SAN DIEGO, April 26, 2011 Cadence ... company focused on in-licensing, developing and commercializing proprietary products ... that the company,s President and CEO Theodore Schroeder will ... during the month of May: Deutsche ...
... 2011 Rochester Medical Corporation (NASDAQ: ROCM ) ... May 5, 2011.  The Company will then hold a quarterly ... begin at 3:30 p.m. central time (4:30 p.m. eastern time). ... can be accessed at Rochester Medical,s website at www.rocm.com ...
Cached Medicine Technology:Rochester Medical Announces Second Quarter 2011 Earnings Conference Call Thursday, May 5, 2011 2
(Date:7/31/2014)... Daily Gossip reveals in its review that the Flat Belly ... loss tips. , The author of the new method ... to implement. Users don’t have to worry, as they will ... counting calories. , The Flat Belly Forever program was ... weeks weight loss program to help sufferers model the perfect ...
(Date:7/31/2014)... its latest blog post, Best Drug Rehabilitation , which ... during a stay in rehab can make a big difference ... at 10 tips to help drug or alcohol addicts cope ... process, and one that former addicts and those who support ... Drug Rehabilitation’s CEO Per Wickstrom . , According ...
(Date:7/31/2014)... The study, The Truth Behind ... episode of care payments for four clinical areas—congestive heart ... replacements (hips and knees). Using the definition of ... Care Improvement program, the study examines these clinical areas ... the country. , “Our study reaffirms that, in most ...
(Date:7/30/2014)... 30, 2014 The Mesothelioma ... Penn's Abramson Cancer Center, will host a regional ... experts in the field of mesothelioma. September 26 marks ... is open to the public, and specifically aimed at ... who have been exposed to asbestos. , The conference ...
(Date:7/30/2014)... events experienced during deployment, returning National Guard soldiers ... if faced with civilian life setbacks, including job ... legal problemsall commonplace in military families. Results of ... School of Public Health are published online in ... , Alcohol abuse is a major concern for ...
Breaking Medicine News(10 mins):Health News:New Best Drug Rehabilitation Blog Posts Looks at 10 Tips for Coping After Drug or Alcohol Rehab 2Health News:Recent Research Finds a New Driver of Cost Variation in Episode Payments 2Health News:Recent Research Finds a New Driver of Cost Variation in Episode Payments 3Health News:September Events: Regional Conference on Mesothelioma in Philadelphia 2Health News:September Events: Regional Conference on Mesothelioma in Philadelphia 3Health News:Vets' alcohol problems linked to stress on the home front 2
... Company (NYSE: PG ) announced net sales growth of ... Organic sales were up five,percent, delivering at the mid-point of ... led by strong growth in the Beauty, Fabric,Care & Home ... earnings,per share increased 12 percent to $1.03 for the quarter., ...
... /Xinhua-PRNewswire-FirstCall/ -- China Medical,Technologies, Inc. (the "Company") ... device company that develops, manufactures and markets ... it will be attending the,Credit Suisse Asian ... Location: Beijing, China, China Medical ...
... Melting Pot Restaurants join,St. Jude Children,s Research Hospital in ... - Dec. 31 to "give thanks for the healthy ... not.", "From the beginning, our involvement with St. ... said Kendra Sartor, vice president,of brand development for The ...
... growth, the global fluoroscopy and mobile C-arms market is forecast to ... form a large chunk of total market, particularly in the developed ... Asia-Pacific. , ... San Jose, CA (PRWEB) October 29, ...
... campaign against the threat of Coronary Heart Disease joined by Royle Family ... ... Tomlinson has warned British men against the threat of Coronary Heart Disease ... that he did not take his heart health seriously in the past ...
... 28 Today the ... responded to a request ... to hold an unnecessary,debate., ... letters, please visit:, http://www.noonprop8.com/downloads/FSchubert102808.pdf ...
Cached Medicine News:Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 2Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 3Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 4Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 5Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 6Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 7Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 8Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 9Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 10Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 11Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 12Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 13Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 14Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 15Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 16Health News:P&G Reports First Quarter EPS of $1.03 Up 12% on 9% Sales Growth 17Health News:The Melting Pot Joins St. Jude Children's Research Hospital(R) for the Fifth Annual Thanks and Giving(R) Campaign 2Health News:The Melting Pot Joins St. Jude Children's Research Hospital(R) for the Fifth Annual Thanks and Giving(R) Campaign 3Health News:Fluoroscopy and Mobile C-arms Unit Sales to Reach 9.6 Thousand Units by 2012, According to New Report by Global Industry Analysts 2Health News:Fluoroscopy and Mobile C-arms Unit Sales to Reach 9.6 Thousand Units by 2012, According to New Report by Global Industry Analysts 3Health News:Ricky Tomlinson Joins Lloydspharmacy Against Coronary Heart Disease 2Health News:Ricky Tomlinson Joins Lloydspharmacy Against Coronary Heart Disease 3
... System provides anterior column support for single ... T1 to L5. The system consists of ... cages that are stacked to a desired ... Carbon Fiber Reinforced Polymer material emulates the ...
... provides anterior column support for single or ... to L5. The system consists of one ... that are stacked to a desired height, ... Fiber Reinforced Polymer material emulates the biomechanical ...
... Cage system is a carbon fiber reinforced ... and biologic functions of posterior lumbar interbody ... provides a device designed to meet the ... cancellous bone, the best possible bone for ...
... is highly adaptable and therefore suitable for ... to its extraordinary small outer diameter and ... of a simple but secure and reliable ... steering instruments around the corner. These characteristics ...
Medicine Products: