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New Deep Vein Thrombosis (DVT) Registry Data Show Clot Quickly Removed, Blood Flow Restored in Large Patient Registry
Date:3/17/2008

g interventional radiologists with physical assistance to break up the clot faster. Because the device disperses the drug throughout the clot, it allows the clot-dissolving drug to work much more quickly -- and often less drug is used, which may lead to a decrease in the risk of bleeding.

Currently, most patients are put on anticoagulation medication (blood thinners), which prevents future clots but does not break up the existing clot.

DVT can lead to serious consequences, including pulmonary embolism (PE) or post-thrombotic syndrome (PTS). Approximately 200,000 individuals die annually as a result of pulmonary embolism. The standard initial treatment with blood thinners is important to prevent a life-threatening pulmonary embolism, but does not treat the existing clot.

Removing these clots is important because about 50 percent of the time, untreated clots will cause PTS, a condition characterized by chronic leg pain, swelling and ulcers. The clot may eventually dissolve on its own, but in the meantime the veins are permanently damaged. PTS is caused by a combination of vein valve damage and blocked blood flow in the vein from residual thrombus (clot).

"My Trellis patients not only felt better right away, but they continued to feel good months later. With anticoagulation alone, it may take days to months for patients to feel better, and some never feel better," said O'Sullivan. Some larger clots do not break up on their own. This leaves the patient with an underlying obstruction or lesion that should be corrected to prevent a future clot. PTS -- while not life threatening -- limits a person's ability to walk or stand for a period of time and can be disabling.

There is growing awareness in the medical community about the need to aggressively treat DVT. Increased focus and awareness of DVT is being brought by new initiatives and standards from a variety of organizations including the Office of the U.S. Surgeon General, the
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SOURCE Society of Interventional Radiology
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