New Data on SEROQUEL XR(TM) in Treatment of Both Major Depressive Disorder and Generalized Anxiety Disorder Presented at APA Annu...(il to achieve a satisfactory response.(6...),Health

Date:5/5/2008

il to achieve a satisfactory response.(6,7) GAD affects about 6.8 million adults in the U.S., with women twice as likely to develop it compared to men, and approximately 30% of patients do not achieve an adequate response to short-term treatment.(8-10) AstraZeneca has investigated the use of SEROQUEL XR, an atypical antipsychotic, in the treatment of MDD as well as GAD, aiming to develop another potential treatment option for patients.

SEROQUEL XR MDD Clinical Studies

In the SEROQUEL XR clinical development program in MDD, short-term monotherapy studies (Studies 1, 2, 3, and 4) and short-term adjunct therapy studies (Studies 6 and 7) used the change in Montgomery-Asberg Depression Rating Scale (MADRS)* scores as the primary assessment of depression symptoms. In the long-term study (Study 5), the primary assessment was time to a depressed event using criteria including the MADRS. Doses of 50 mg, 150 mg and 300 mg of SEROQUEL XR were studied in the MDD program.(11)

"New MDD therapy options are clearly needed. Studies have shown that at least one-third of MDD patients who are treated with antidepressants fail to achieve a satisfactory response," said Dr. Richard Weisler, Adjunct Professor of Psychiatry at University of North Carolina School of Medicine, Adjunct Assistant Professor at Duke University Medical Center and lead investigator on the MDD short-term monotherapy study presented today. "Additionally, for those patients who do achieve a response from treatment with antidepressants, it may often take a few weeks of treatment before a benefit is seen. In the short- term monotherapy study presented today at APA, patients taking SEROQUEL XR had a significant improvement in depressive symptom scores as early as the fourth day of treatment compared with patients taking placebo."

The following MDD studies were presented at the APA meeting:

-- Study 1 (Poster # NR3-101) -- In a six-week, multicenter, double-blind

study, 72
'/>"/>

SOURCE AstraZeneca Copyright©2008 PR Newswire. All rights reserved

0 GOOD

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Related medicine technology :

1. AstraZeneca Submits sNDAs for SEROQUEL XR(TM) for the Treatment of Bipolar Mania and Bipolar Depression
2. SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia
3. INVEGA(TM) Significantly Reduced Symptoms of Schizophrenia Compared to SEROQUEL(R) in Acutely Ill, Hospitalized Patients
4. Keppra XR(TM) Extended-Release Tablets Filed with the FDA
5. UCB Announces Positive Phase III Trial Results for Keppra XR(TM) (levetiracetam) Extended-Release Tablets
6. Shire to Present Additional Scientific Data on ADHD Treatment Portfolio at American Psychiatric Association Annual Meeting
7. Vicus Therapeutics Records Last Patient Visit of Phase 2, VT-122 Trial for the Treatment of Cachexia in Patients With Advanced Lung Cancer
8. Data Show Preoperative Assessment of Breast Cancer Patients Enables Early Diagnosis, Successful Treatment of Lymphedema
9. Statement From the Lupus Foundation of America Regarding the Release of Top-Line Results From a Study of Rituxan for the Treatment of Lupus
10. ROXRO PHARMA Announces Positive Clinical Proof of Concept Results for Novel Intranasal Migraine Treatment
11. Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL