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New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma
Date:5/30/2008

IIIA NSCLC in the large MAGRIT trial. The gene profiling data presented at ASCO will be further validated during the ongoing NSCLC MAGRIT Phase III trial.

"This is an exciting time to be amongst those at the forefront of cancer immunotherapy research," said Dr. Vincent Brichard, Vice-President, Head of Cancer Immunotherapeutics at GSK Biologicals. "These data presented today and the launch of the large MAGRIT trial are indicative of GSK's ongoing commitment to researching new ways of treating cancer and focus on developing the right medicine tailored to identify the patients most likely to benefit from it. We are keenly anticipating the results of the Phase III trial and what it may mean for the future of cancer treatment."

About ASCIs and MAGE-A3 ASCI

GSK's ASCIs represent a novel class of medicines designed to train the immune system to recognize and eliminate cancer cells in a highly specific manner. These novel cancer immunotherapeutics combine tumor antigens, delivered as purified recombinant proteins, and GSK's proprietary Adjuvant Systems which are specific combinations of immunostimulating compounds selected to increase the anti-tumor immune response. ASCIs will be investigated to support their use to reduce the risk of tumor recurrence following surgery, or to impact tumor growth in an early metastatic setting.

The highly specific mode of action of GSK's ASCIs may not only avoid harming the normal tissue but also aid in selecting patients eligible for the treatment, depending on the expression of the tumor antigens.

MAGE-A3 is a tumor-specific antigen that is expressed in a large variety of cancers, including Melanoma, Non-Small Cell Lung Cancer, Head and Neck Cancer, Bladder Cancer, with no expression in normal cells. Expression of the MAGE-A3 gene has been observed in testicular cells but without antigen presentation capabilities.

MAGE-A3 protein has been in-licensed by GSK from the Ludwig Institute for Cancer Re
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SOURCE GlaxoSmithKline (GSK)
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