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New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma
Date:5/30/2008

of given genes and the clinical response induced by the MAGE-A3 ASCI in metastatic melanoma(2).

In addition, GSK presented data on the genetic profiling of patients with NSCLC. In a retrospective analysis, a predictive gene signature similar to that observed in melanoma was associated with a lower rate of disease recurrence in the MAGE-A3 treated group(3).

"These phase II data mark another significant milestone for the development of the MAGE-A3 ASCI as a potential novel cancer therapy. Validation of a predictive gene signature, combined with selection of patients who express cancer antigens of interest, may allow GSK to improve predictions of a patient's clinical response to treatment with cancer immunotherapeutics," said Johan Vansteenkiste, Professor of Internal Medicine, Faculty of Medicine, Catholic University of Leuven, Belgium. "They also provide further positive proof-of-concept Phase II data which highlight the importance of the ongoing MAGRIT Phase III trial in Non-Small Cell Lung Cancer."

Phase II Melanoma Data: abstract # 9065(1)

A randomized, open-label Phase II study designed to evaluate MAGE-A3 recombinant protein combined with two different Adjuvant Systems was conducted. A total of 72 patients with measurable metastatic MAGE-A3-positive cutaneous melanoma (unresectable or in transit stage III or stage IV M1a) were randomized to receive immunization with MAGE-A3 protein combined with either AS15 or AS02B as first-line metastatic treatment. Patients were to receive a maximum of 24 immunizations over four years. Clinical activity is assessed by the RECIST criteria, the international standards for evaluation of solid tumors. Complete response (CR) and partial response (PR) i.e, disappearance or significant reduction of tumor, were reported in four patients in the AS15 group (3 CR and 1 PR) with two of these ongoing for more than two years; in the AS02B arm, one patient showed a partial response which lasted for 6 months.1 The
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SOURCE GlaxoSmithKline (GSK)
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