Navigation Links
New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma
Date:5/30/2008

Gene Expression Profiling of Tumor is Correlated With Clinical Response

CHICAGO, May 30 /PRNewswire-FirstCall/ -- New data presented by GlaxoSmithKline (GSK) today highlighted the potential of its investigational MAGE-A3 Antigen-Specific Cancer Immunotherapeutic (ASCI) through results of three studies evaluating highly targeted immunotherapy as a treatment for metastatic melanoma and non-small cell lung cancer (NSCLC). These data were presented at the 2008 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago (Abstract Nos: 9065(1), 9045(2) and 7501(3)).

A randomized, open label Phase II study designed to evaluate two different formulations of the MAGE-A3 ASCI in patients with metastatic melanoma has been conducted. In this study, the ASCI, which is a combination of MAGE-A3 recombinant protein and a GSK proprietary Adjuvant System, was evaluated and resultant data suggest a positive trend for clinical response. These data also demonstrate the induction of a desirable immune response, including humoral and cellular responses. These study results represent a second positive trend for clinical activity for the novel MAGE-A3 cancer immunotherapeutic, following encouraging clinical results reported in a separate double-blind, placebo-controlled Phase II study of patients with NSCLC(4). The encouraging results from the Phase II NSCLC study have led to a Phase III safety and efficacy trial in MAGE-A3-positive NSCLC patients (stage IB, II and IIIA) who have undergone complete surgical resection (MAGRIT; MAGE-A3 Adjuvant Non-Small Cell LunG CanceR ImmunoTherapy).

At this year's ASCO, GSK also presented data regarding the use of the genetic profiling of melanoma in predicting clinical outcomes of treatment with MAGE-A3 ASCI. Biopsies performed on the melanoma tumors prior to immunization were used to identify genetic markers expressed by the disease. These markers enabled researchers to establish a correlation between the expression
'/>"/>

SOURCE GlaxoSmithKline (GSK)
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Presentation of Data on Progens Cancer Epigenetic Targets Platform
2. Genmab Announces Updates on Phase III Cancer Studies
3. Access Pharmaceuticals Presents Favorable Ovarian Cancer Data and Clinical Update on ProLindac(TM) Development at Prestigious International Symposium
4. Sunesis Pharmaceuticals to Present Interim Clinical Data From Voreloxin (Formerly SNS-595) Ovarian Cancer Trial at 44th ASCO Annual Meeting and Acute Myeloid Leukemia Trials at 13th EHA Congress
5. BiPar Sciences Expands Clinical Development of BSI-201, A Novel PARP Inhibitor, With Phase 2 Trial in Uterine Cancer
6. Prostate Cancer Treatment Offers Results Without Side Effects
7. TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)
8. First Patient Enrolled in Global Phase III Study of Bevacizumab and Trastuzumab in Early Breast Cancer
9. Node-Negative Early Stage Breast Cancer Patients Benefit from Taxotere(R)-Based Chemotherapy
10. Exiqon Forms Research Collaboration With M. D. Anderson Cancer Center
11. Ovarian Cancer Vaccine Clinical Trial Begins at Cancer Treatment Centers of America
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... March 5, 2015  BioPhotas, Inc., an FDA registered ... patented photo-therapeutic technologies to treat skin, muscle and joint ... Semper Fi Fund to provide BioPhotas, flagship product, the ... pain management solutions.  Commenting on the ... who used the Celluma at the Warrior Hope and ...
(Date:3/5/2015)... HAMILTON, N.J. , March 5, 2015 /PRNewswire/ ... laboratory which specializes in high complexity, state-of-the-art, automated ... offering new Human Papillomavirus (HPV) testing which utilizes ... platforms. Each year, approximately 12,000 women ... the United States . Genital Human Papillomaviruses ...
(Date:3/5/2015)... March 5, 2015  ANI Pharmaceuticals, Inc. ("ANI") ... it has acquired the approved abbreviated new drug ... 100mg and 150mg, previously marketed by Teva Pharmaceuticals.  ... this product was approximately $39 million in 2014. ... President and CEO of ANI Pharmaceuticals, stated, "This ...
Breaking Medicine Technology:BioPhotas, Inc. and the Semper Fi Fund Work Together to Provide Pain Relief to Injured Service Members 2BioPhotas, Inc. and the Semper Fi Fund Work Together to Provide Pain Relief to Injured Service Members 3Medical Diagnostic Laboratories, L.L.C., the Institute for Biomarker Research Announces New HPV Tests 2Medical Diagnostic Laboratories, L.L.C., the Institute for Biomarker Research Announces New HPV Tests 3ANI Pharmaceuticals Acquires Generic Drug Product from Teva Pharmaceuticals 2ANI Pharmaceuticals Acquires Generic Drug Product from Teva Pharmaceuticals 3
(Date:3/5/2015)... March 05, 2015 Risperdal lawsuits ... a Pennsylvania mass tort litigation currently underway in ... jury has begun hearing testimony in the proceeding’s ... antipsychotic medication can cause gynecomastia, or male breast ... question was filed on behalf of a plaintiff ...
(Date:3/5/2015)... HomeCEUConnection.com is proud to support ... on their nutrition CEUs. To raise awareness ... HomeCEUConnection.com is offering 10% off selected nutrition ... NUTRITION2015 . , High Quality Continuing Education ... high-quality continuing education courses for Physical Therapists, ...
(Date:3/5/2015)... Battle Creek, Michigan (PRWEB) March 05, 2015 ... celebrates the opportunity to shatter myths about drug and ... Forever Recovery has released a Fact Sheet with information ... substance abuse. Launched in 2010 by the National Institute ... about drugs and alcohol aims to counteract the illusions ...
(Date:3/5/2015)... Calif. (PRWEB) March 05, 2015 ... beverages, today announced at Natural Products Expo West that ... are now 100 percent soy and dairy free. Califia ... single serve bottle and are packed with six grams ... protein that includes fiber, B vitamins and magnesium. , ...
(Date:3/5/2015)... 2015 Supply & Demand Chain Executive ... “Pros to Know” in the supply chain industry, and ... MEBC’s leadership team were included on this year’s list! ... this award due to their hard work, their commitment ... meeting and resolving client needs and challenges. ...
Breaking Medicine News(10 mins):Health News:Risperdal Lawsuits Move Forward in Pennsylvania, as Bernstein Liebhard LLP Comments on Start of Second Gynecomastia Trial 2Health News:Risperdal Lawsuits Move Forward in Pennsylvania, as Bernstein Liebhard LLP Comments on Start of Second Gynecomastia Trial 3Health News:HomeCEUConnection.com Offers Nutrition CEUs this March to Celebrate Nutrition Month 2Health News:A Forever Recovery Issues New Tips for Sobriety for National Drug Facts Week 2Health News:Califia Farms Vegan Protein and New Single Serve Almondmilks to Hit Supermarket Shelves this Month 2Health News:Califia Farms Vegan Protein and New Single Serve Almondmilks to Hit Supermarket Shelves this Month 3Health News:MEBC Leaders Awarded Supply Demand Chain Executive Pros to Know Title For 2015 2
... Food Including Health ... Ratings, ... flying than ever before. In fact, according to the Airline,Transportation Association (ATA) ... what are the "best" and,"worst" food choices is a valuable tool for ...
... Barometer tracks the business issues, and best practices of privately-held companies ... the views of, 291 CEOs: 130 from companies in the product ... ... sector., NEW YORK, Nov. 14 ...
... Health Status; Anthem Develops Innovative ... Health of Hoosiers, INDIANAPOLIS, Nov. 14 Anthem Blue ... Health Index, a program that,incorporates public health data to identify ... assembled a dedicated team to collaborate,with local and state officials, ...
... say seniors first diagnosed in childhood , , WEDNESDAY, Nov. 14 (HealthDay ... he still remembers the day he was first diagnosed with ... hospital at five years of age, and I thought to myself, ... hospital before, I just thought that,s where you went to die," ...
... Calif., Nov. 14 Weighing in with a ... Naturals most,popular Omega-3 fatty acid formula, is now ... called Ultimate Omega 500 provides,the same exceptionally high ... soft gel allows for easier swallowing. Ideal for ...
... (NYSE: MYL ),announced that it has priced ... 6.50% mandatory convertible preferred stock ("preferred,stock") at $1,000 ... stock at $14,per share pursuant to a shelf ... Commission. The underwriters have options to,purchase approximately 279,000 ...
Cached Medicine News:Health News:2007 DietDetective.com Airline Snack Food Investigation 2Health News:Health Care Costs are Hurting 57% of Fast-Growing Private Businesses 2Health News:Health Care Costs are Hurting 57% of Fast-Growing Private Businesses 3Health News:Health Care Costs are Hurting 57% of Fast-Growing Private Businesses 4Health News:Anthem Blue Cross and Blue Shield in Indiana Releases State Health Index 2Health News:Anthem Blue Cross and Blue Shield in Indiana Releases State Health Index 3Health News:Anthem Blue Cross and Blue Shield in Indiana Releases State Health Index 4Health News:A Full and Long Life, Despite Diabetes 2Health News:A Full and Long Life, Despite Diabetes 3Health News:A Full and Long Life, Despite Diabetes 4Health News:Nordic Naturals Introduces Ultimate Omega 500 - Their Best Selling Formula Now Available in a Smaller Size Soft Gel! 2Health News:Mylan Prices Offerings of Common Stock and Mandatory Convertible Preferred Stock 2Health News:Mylan Prices Offerings of Common Stock and Mandatory Convertible Preferred Stock 3
... ORTHOSET Radiopaque Bone Cement ... system: a sterile,ampule containing bone ... pack, and a sterile polyethylene ... a peelable pouch. The interiors ...
Antibiotics (Gentamicin) loaded, high viscosity bone cement for digital use with an average setting time of approx. 6-8 Min., 41.6g of powder and 14.4g of liquid....
... new thinking to address common problems associated ... mm diameter outer arthroscope sheath, the shorter, ... Videoscope has superior access and mobility in ... and especially in the elbow and ankle. ...
... The OMEGA 180 features a wide ... One-Step Small and Variable Pupil Control (U.S. ... pupil sizes down to 1.2mm. Heine's unique ... illumination, making learning BIO easier, and simplifying ...
Medicine Products: