Navigation Links
New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma
Date:5/30/2008

Gene Expression Profiling of Tumor is Correlated With Clinical Response

CHICAGO, May 30 /PRNewswire-FirstCall/ -- New data presented by GlaxoSmithKline (GSK) today highlighted the potential of its investigational MAGE-A3 Antigen-Specific Cancer Immunotherapeutic (ASCI) through results of three studies evaluating highly targeted immunotherapy as a treatment for metastatic melanoma and non-small cell lung cancer (NSCLC). These data were presented at the 2008 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago (Abstract Nos: 9065(1), 9045(2) and 7501(3)).

A randomized, open label Phase II study designed to evaluate two different formulations of the MAGE-A3 ASCI in patients with metastatic melanoma has been conducted. In this study, the ASCI, which is a combination of MAGE-A3 recombinant protein and a GSK proprietary Adjuvant System, was evaluated and resultant data suggest a positive trend for clinical response. These data also demonstrate the induction of a desirable immune response, including humoral and cellular responses. These study results represent a second positive trend for clinical activity for the novel MAGE-A3 cancer immunotherapeutic, following encouraging clinical results reported in a separate double-blind, placebo-controlled Phase II study of patients with NSCLC(4). The encouraging results from the Phase II NSCLC study have led to a Phase III safety and efficacy trial in MAGE-A3-positive NSCLC patients (stage IB, II and IIIA) who have undergone complete surgical resection (MAGRIT; MAGE-A3 Adjuvant Non-Small Cell LunG CanceR ImmunoTherapy).

At this year's ASCO, GSK also presented data regarding the use of the genetic profiling of melanoma in predicting clinical outcomes of treatment with MAGE-A3 ASCI. Biopsies performed on the melanoma tumors prior to immunization were used to identify genetic markers expressed by the disease. These markers enabled researchers to establish a correlation between the expression
'/>"/>

SOURCE GlaxoSmithKline (GSK)
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Presentation of Data on Progens Cancer Epigenetic Targets Platform
2. Genmab Announces Updates on Phase III Cancer Studies
3. Access Pharmaceuticals Presents Favorable Ovarian Cancer Data and Clinical Update on ProLindac(TM) Development at Prestigious International Symposium
4. Sunesis Pharmaceuticals to Present Interim Clinical Data From Voreloxin (Formerly SNS-595) Ovarian Cancer Trial at 44th ASCO Annual Meeting and Acute Myeloid Leukemia Trials at 13th EHA Congress
5. BiPar Sciences Expands Clinical Development of BSI-201, A Novel PARP Inhibitor, With Phase 2 Trial in Uterine Cancer
6. Prostate Cancer Treatment Offers Results Without Side Effects
7. TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)
8. First Patient Enrolled in Global Phase III Study of Bevacizumab and Trastuzumab in Early Breast Cancer
9. Node-Negative Early Stage Breast Cancer Patients Benefit from Taxotere(R)-Based Chemotherapy
10. Exiqon Forms Research Collaboration With M. D. Anderson Cancer Center
11. Ovarian Cancer Vaccine Clinical Trial Begins at Cancer Treatment Centers of America
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... , Dec. 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... pharmacy, is proud to announce Jennifer Hagerman , ... Diplomat, will take office as the president of the ... induction ceremony will take place Feb. 28, 2015, at ... held at the Renaissance Center in Detroit, ...
(Date:12/24/2014)... KENNEWICK, Wash. , Dec. 23, 2014 /PRNewswire/ ... stage development company engaged primarily in the development ... and therapeutic applications, today announced that it has ... the Food and Drug Administration ("FDA") for marketing ... to Section 513(f)(2) of the U.S. Food, Drug ...
(Date:12/24/2014)... DALLAS , Dec. 23, 2014  Lockton ... operation of Lockton Companies, announced the addition of ... Foerster will join Lockton Dunning,s Pharmacy Consulting team, ... years of relevant industry experience to the position.  ... Managed Market Sales at Diplomat Specialty Pharmacy, where ...
Breaking Medicine Technology:Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3Kim Foerster Joins Lockton Companies 2
... /PRNewswire-Asia-FirstCall/ -- China Medicine Corporation (OTC Bulletin Board: ... manufacturer, developer and distributor of Western pharmaceuticals, traditional ... the People,s Republic of China, today announced that ... to stockholder approval, the 2011 Long-Term Incentive Plan ...
... N.C., March 3, 2011 Recent ... Corporate governance changes announced Term loan repaid ... Fourth quarter 2010 financial results announced ... CSA ), healthcare,s preferred real estate partner, is a REIT ...
Cached Medicine Technology:China Medicine Corporation Adopts New Incentive Compensation Plans 2China Medicine Corporation Adopts New Incentive Compensation Plans 3Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 2Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 3Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 4Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 5Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 6Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 7Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 8Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 9Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 10Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 11Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 12Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 13Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 14Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 15Cogdell Spencer Announces Fourth Quarter 2010 Results and Completion of Strategic Plan 16
(Date:12/25/2014)... 2014 “Every three months the trends for ... sweetheart evening dress will be one of the hottest styles ... Yunx.co.uk says. Today, the company releases 26 A-line sweetheart evening ... 80% off. , “We are trying our best to ... our latest designs. Along with affordable prices, we provide discounted ...
(Date:12/25/2014)... CA (PRWEB) December 25, 2014 The short ... was created in honor of a true 9/11 hero, ... two film festivals including the 24 hours of Nuremberg International ... in Bangladesh. , Actress, screenwriter and director Luciana ... produce this film together with her husband, Gregory Graham ...
(Date:12/25/2014)... 25, 2014 Helen Harris’ RP (Retinitis ... Hills, California after an 8 year battle with breast ... Eve evening in her home in Woodland Hills California ... cancer. , As the founder and ... she pioneered and championed many of today's greatest breakthroughs ...
(Date:12/25/2014)... Thompson HealthDay Reporter WEDNESDAY, ... complex chronic illnesses can receive effective, less expensive care from ... access to a team of dedicated health care professionals, a ... seriously ill and need either hospitalization or a trip to ... medical home clinic at the University of Texas in Houston ...
(Date:12/25/2014)... -- Among early stage breast cancer patients who undergo ... percent will eventually develop leukemia as a result of ... comes from a review of more than 20,000 breast ... suggests that the risk for developing treatment-related leukemia, though ... "The frequency of bone marrow cancers such as ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... Drug Spending Despite Higher Use - - Cancer ... - ... LAKES, N.J., May 15 Diabetes,treatments are now the leading driver ... a decade of,reigning in the top position, as generic drugs cut ...
... May 15 Alexza,Pharmaceuticals, Inc. (Nasdaq: ALXA ) ... during the Seventh Annual JMP Securities,Research Conference on Monday, ... the Citi Investment Research Global Healthcare Conference on Wednesday,May ... JMP presentation will be webcast from The Ritz-Carlton Hotel ...
... May 15 MS -- "Eat your vegetables!" is ... it that many young children,don,t seem to like vegetables? ... prenatally," says Jane Kostelc, early childhood specialist,at Parents as ... Pennsylvania State University shows that unborn babies may detect,taste ...
... UCLAs Jonsson Cancer Center and the Department of Urology have ... in a Western diet helps prevent prostate cancer in mice, ... that closely mimics human cancer, researchers said. , The study, ... journal Cancer Research, focused on fat from corn oil, which ...
... May 20, 2008 Transplantation of muscle-derived stem ... for patients suffering from urinary incontinence following a ... 103rd Annual Scientific Meeting of the American Urological ... from iatrogenic sphincter damage may benefit from this ...
... National Eating,Disorders Association (NEDA) and the Academy for ... rights, launching a statewide initiative,in Washington to help ... disorders., Entitled the Worldwide Charter for Action ... among patients, families and their,treatment team to ensure ...
Cached Medicine News:Health News:Diabetes Drugs Emerge as Top Force in Drug Spending Growth 2Health News:Diabetes Drugs Emerge as Top Force in Drug Spending Growth 3Health News:Diabetes Drugs Emerge as Top Force in Drug Spending Growth 4Health News:Diabetes Drugs Emerge as Top Force in Drug Spending Growth 5Health News:Alexza's Corporate Presentation to be Webcast at the Seventh Annual JMP Securities Research Conference and the 2008 Citi Investment Research Global Healthcare Conference 2Health News:Alexza's Corporate Presentation to be Webcast at the Seventh Annual JMP Securities Research Conference and the 2008 Citi Investment Research Global Healthcare Conference 3Health News:Eat Your Vegetables - That Means You, Parents! 2Health News:Reducing intake of dietary fat prevents prostate cancer in mice 2Health News:Eating Disorder Experts, Advocates Introduce Patient Bill of Rights To Ensure Quality Care in Washington State and Throughout U.S. 2
... Cross-match tubes are available ... serum tube contains a clotting ... cross-match tests where serum is ... EDTA cross-match tube is suitable ...
Inquire...
... K2 / gel tubes are for ... molecular diagnostics and for viral load ... blood remain stable at room temperature ... optimal results, it is recommended to ...
Glass Whole Blood Tube with K3EDTA...
Medicine Products: