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New Data from Silence's Atu027 Anticancer Trial Published at ASCO
Date:5/16/2012

LONDON, May 17, 2012 /PRNewswire/ --

- Atu027, a First in Class RNAi Therapy, Demonstrates Potential

- Antitumour Activity in Cancer Patients and Possible Biomarker Identified

Silence Therapeutics to Announce New Data from Phase I Study of Atu027 in Solid Tumours At 2012 ASCO Annual Meeting

Silence Therapeutics plc (AIM: SLN) ("Silence" or the "Company"), a leading global RNA interference (RNAi) therapeutics company, today announces that top line data from its ongoing Phase I trial of Atu027 show that of the 33 patients treated in the first 10 cohorts of the study, 10 patients experienced stable disease after three months. Two patients with neuroendocrine cancers had disease stabilisation for nine and 12 months respectively, including partial regression of liver metastases in one patient. Another patient with breast cancer demonstrated regression of liver metastases. Importantly, among various biomarkers tested, sVEGFR-1 plasma levels decreased significantly upon treatment further confirming a potential biological effect of Atu027.  

Silence will publish the latest data from its ongoing Phase I study of Atu027, its lead internal therapeutics candidate, at the 2012 American Society of Clinical Oncology ("ASCO") Annual Meeting in Chicago, Illinois, 1-5 June 2012. Further data from the ongoing Phase I Atu027 clinical study will also be the subject of a presentation with the following details:

Abstract Title: Anti-metastatic activity of Atu027, a liposomal small interfering RNA formulation, targeting protein kinase N3 (PKN3): Final results of a phase I study in patients with advanced solid tumours. Abstract #: 98347 Presentation Date/Time: Mon, June 04, 2012 / 16:00 - 18:00 Location: Networking Lounge, Level 3, North Presenters: Klaus Giese [http://silence-therapeutics.com/about-us/man
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SOURCE Silence Therapeutics Plc
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