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New Data for Abbott's TRILIPIX(R) (fenofibric acid) in Combination with Rosuvastatin Calcium Shows Improvement on Key Lipids for Cholesterol Management
Date:3/29/2009

one and mean percent change in LDL with the combination versus TRILIPIX alone.

About the Study Results

Patients treated with the combination of TRILIPIX 135 mg and rosuvastatin calcium 5 mg had an increase in HDL of 23 percent compared to 12.4 percent increase with rosuvastatin calcium 5 mg alone (p<0.001), and decrease in triglycerides of 40.3 percent compared to a reduction of 17.5 percent with rosuvastatin calcium 5 mg alone (p<0.001). LDL was reduced by 28.7 percent with the combination compared to a 4.1 percent reduction with TRILIPIX 135 mg alone (p<0.001).

The results of this study were consistent with those of the previous studies of TRILIPIX in combination with the other two most commonly used doses of rosuvastatin calcium (10 mg and 20 mg). The combinations both showed greater improvement in HDL and triglycerides compared to rosuvastatin calcium alone and greater improvements in LDL than TRILIPIX alone. The combination of TRILIPIX with the highest dose of rosuvastatin calcium (40 mg) has not been studied.

"The recent approval of TRILIPIX and the results of this combination study further support Abbott's clinical program and demonstrate how this combination therapy improves lipid levels," said Eugene Sun, M.D., vice president, Global Pharmaceutical Clinical Development, Abbott.

TRILIPIX Clinical Development Program

The TRILIPIX clinical program studied 3,458 patients with mixed dyslipidemia in four controlled studies where patients received TRILIPIX alone, TRILIPIX in combination with one of the three most commonly prescribed statins (atorvastatin, simvastatin or rosuvastatin) or statin alone. The clinical program also included a 52-week, long-term, open-label extension study.

TRILIPIX Indications

TRILIPIX(R) is a prescription medicine that can be used along with diet to lower triglycerides and LDL (bad) cho
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SOURCE Abbott
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