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New Data for Abbott's TRILIPIX(R) (fenofibric acid) in Combination with Rosuvastatin Calcium Shows Improvement on Key Lipids for Cholesterol Management
Date:3/29/2009

ased when TRILIPIX is used with a statin.

"More comprehensive treatment is often needed in certain patients with mixed dyslipidemia to help reach targets for all three key lipids," said Eli Roth, M.D., University of Cincinnati College of Medicine, and Sterling Research Group, Cincinnati, Ohio. "The results from this study are encouraging because TRILIPIX combined with the lowest available dose of rosuvastatin calcium improved LDL cholesterol, HDL cholesterol and triglycerides."

More than 100 million American adults have lipid problems, and 35 percent reported being treated with lipid-altering medications. Of the patients being treated, fewer than one in three (30 percent) were at recommended levels for all three key lipids. Treatment guidelines endorsed by the National Cholesterol Education Panel, the American College of Cardiology and the American Heart Association have called for more aggressive management of lipids, including a lower LDL goal for many patients, as well as more aggressive management of HDL and triglycerides.

About the Study Design

The efficacy and safety of TRILIPIX in combination with rosuvastatin calcium was evaluated in a multicenter, randomized, double-blind, parallel group, 12-week, Phase III study of 760 patients with mixed dyslipidemia. Patients included in the study had multiple lipid problems, with an LDL greater than or equal to 130 mg/dL, triglycerides greater than or equal to 150 mg/dL and HDL less than 40 mg/dL for men and less than 50 mg/dL for women.

Following a six-week period in which patients were not allowed to take cholesterol medications, patients were randomized to receive TRILIPIX 135 mg alone, rosuvastatin calcium 5 mg alone or TRILIPIX 135 mg in combination with rosuvastatin calcium 5 mg. The primary efficacy comparisons were mean percent changes in triglycerides and HDL with the combination versus rosuvastatin calcium al
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SOURCE Abbott
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