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New Data Support Role of Prometheus Laboratories' Novel Assay in Optimizing IBD Treatment Management
Date:5/22/2012

ourse of action to restore treatment response," said Brian Feagan, M.D., Director, Robarts Clinical Trials, Robarts Research Institute.  "Our data suggest that antibodies-to-infliximab are highly predictive of disease activity and may help establish a new standard of care that includes combined IFX-ATI monitoring for IBD patients treated with biologics."

Oral presentations:

  • Novel infliximab (IFX) and antibody-to-infliximab (ATI) assays are predictive of disease activity in patients with Crohn's disease (CD), presentation #565 in Research Forum by Brian G. Feagan et al on May 20 (4:30-4:45 p.m. PDT)
  • Antibodies to infliximab can either be persistent or transient: a retrospective case-control study in IBD patients treated with infliximab maintenance therapy, presentation #563 in Research Forum by Niels Vande Casteele et al on May 20 (4:00-4:15 p.m. PDT)
  • Combined serologic, genetic, and inflammatory markers can accurately differentiate non-IBD, Crohn's disease, and ulcerative colitis patients, presentation #166 in Research Forum by Scott E. Plevy et al on May 19 (3:30-3:45 p.m. PDT)
  • Blood microRNA (miRNA) Expression Patterns Can Identify Inflammatory Bowel Disease (IBD) Patients with Dysplasia and Cancer, presentation #108 in Research Forum by Francis A. Farraye et al on May 19 (10:30-10:45 a.m. PDT)

Poster presentations:

  • New assay to detect infliximab levels and anti-infliximab antibodies from a single serum sample is useful in measuring efficacy of treatment with infliximab in children with IBD (#Sa2037), May 19
  • Accelerated clearance of serum infliximab therapy for acute ulcerative colitis is associated with treatment failure (#Sa2031), May 19
  • Association of serum infliximab and antibodies to infliximab to long term clinical outcome in acute ulcerative colitis (#Sa2047), May 19
  • Comparis
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SOURCE Prometheus Laboratories Inc.
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