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New Data Support Role of Prometheus Laboratories' Novel Assay in Optimizing IBD Treatment Management
Date:5/22/2012

SAN DIEGO, May 22, 2012 /PRNewswire/ -- Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, announced today the thirteen abstracts relating to its proprietary diagnostic platform presented at Digestive Disease Week (DDW) 2012.

The abstracts (see full list below) highlight Prometheus's innovative technologies aimed at helping healthcare providers personalize patient care with the goal of ultimately helping to improve patient outcomes.  Topics span across a wide spectrum of scientific and clinical research that offers novel solutions to current and future patient needs.  "We are proud to continue to lead the way toward personalized medicine. We are committed to continue to advance our novel technology platforms and partner with the GI community to help bring valuable products to market with the goal of continuing to improve patient outcomes," said Joseph M. Limber, President and Chief Executive Officer of Prometheus.

In the Feagan et al abstract, antibody-to-infliximab (ATI) levels proved highly predictive of disease activity, as measured by median C-reactive protein (CRP) concentrations - regardless of serum infliximab (IFX) levels.   Both ATI and IFX levels were measured using the novel Prometheus mobility shift assay among more than 1,487 samples from 532 participants in four prospective Crohn's disease randomized controlled trials.  CRP concentrations were higher among ATI positive patients with IFX levels < 3 ug/ml (8.4 vs. 5.65; p < 0.001) as well as IFX levels > 3 ug/ml (9.9 vs. 1.5; p < 0.01), as compared to ATI negative patients.

The development of these antibodies can shorten the duration of clinical response to IFX and decrease the likelihood of an IBD patient remaining in remission.

"Knowing exactly what factors contribute to a patient's loss of response to a biologic therapy is ideal for accurately and efficiently determining an appropriate c
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SOURCE Prometheus Laboratories Inc.
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