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New Data Support Role for Monitoring of Cell-Mediated Immunity in Adult Patients Following Renal Transplantation
Date:8/21/2008

rs state that this was an insufficient number of patients to validate the role of the ImmuKnow assay in monitoring risk for organ rejection. The mean ATP level of the three patients who underwent acute organ rejection was 247 +/- 193 ng/mL.

"We are pleased to see the data from this study support earlier published data on the use of the ImmuKnow assay in monitoring adult patients after a renal transplant," stated Brad L. Stewart, president of Cylex. "Clearly there is further research needed to elucidate the appropriate standards for use of cell-mediated immunity to monitor risk for infection and rejection in selected patient categories. However, this publication further illustrates the potential risks for infection associated with over-immunosuppression in renal transplant patients, and the potential value of the ImmuKnow assay in monitoring immune status."

*Sanchez-Velasco P, Rodrigo E, Valero R, et al. Intracellular ATP concentrations of CD4 cells in kidney transplant patients with and without infection. Clin Transplant. 2008;22:55-60.

About ImmuKnow(R)

ImmuKnow is the immune cell function assay cleared by the FDA to detect cell-mediated immunity (CMI) in adult patient populations undergoing immunosuppressive therapy for organ transplantation by measuring the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation.

The ImmuKnow test is a qualitative assay and does not directly quantify the level of immunosuppression. Results of ImmuKnow assays should be used in conjunction with clinical presentation, medical history, and other clinical indicators when assessing the immune status of any individual patient. The uses of the ImmuKnow assay as described in these studies have not been approved or cleared by the FDA. The Company may use data from these or similar studies to support future FDA marketing applications for similar indications.

About Cylex, Inc.

Cylex(TM) is a privately h
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SOURCE Cylex(TM)
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