Navigation Links
New Data Shows Veramyst Effectively Treats Symptoms of Perennial Allergic Rhinitis
Date:11/11/2007

Study Also Demonstrated Significant Improvement in Eye Symptoms

DALLAS, Nov. 11 /PRNewswire/ -- Veramyst(TM) (fluticasone furoate) Nasal Spray demonstrated significant improvement in the treatment of nasal and ocular allergy symptoms of perennial allergic rhinitis (PAR) in patients 12 years of age and older, according to a clinical study presented today at the annual scientific meeting of the American College of Allergy, Asthma & Immunology (ACAAI).

Perennial allergic rhinitis, or PAR, refers to allergy symptoms that occur year-round in response to triggers such as dust mites, animal dander and mold. Seasonal allergic rhinitis, or SAR, refers to only seasonal symptoms, for example an allergic response to springtime pollen.

Results of this 6-week global clinical study showed that Veramyst 110 mcg administered once-daily was significantly more effective than placebo in relieving overall nasal allergy symptoms (nasal congestion, rhinorrhea, sneezing and nasal itching), the primary efficacy endpoint. Veramyst also showed statistically significant improvement in relieving overall eye symptoms (itching/burning, tearing/watering and eye redness), a secondary study endpoint. Veramyst administered once-daily also provided sustained, 24-hour efficacy for both nasal and eye symptoms of perennial allergies.

"This study demonstrated the efficacy of Veramyst for patients suffering from both nasal and ocular symptoms all year long, not just during spring and fall allergy seasons," said study author Eli Meltzer, M.D., co-director of the Allergy & Asthma Medical Group and Research Center in San Diego, Calif. "The 24-hour relief from symptoms is also a key patient benefit."

In the 6-week double-blind, placebo-controlled study, 302 individuals 12 years of age and older, were randomized to receive either Veramyst 110 mcg once daily or placebo. Patients rated their nasal symptoms (nasal congestion, itching, rhinorrhea and sneezing) and eye symptoms (eye itching/burning, tearing/watering and redness) on a patient-rated scale at baseline and after six weeks.

Veramyst was associated with statistically significantly greater improvement in nasal symptoms than placebo; the mean change from baseline was -3.95 for Veramyst versus -2.69 for placebo (p<0.001). Patients taking Veramyst likewise reported significantly greater improvement in eye symptoms versus those taking placebo (-1.92 mean change from baseline versus -1.41 for placebo; p=0.004). Furthermore, patients taking Veramyst experienced sustained 24-hour relief from nasal symptoms, as measured by the mean change from baseline in next-day pre-dose symptom scores (-3.82 for Veramyst versus -2.36 for placebo; p<0.001) and eye symptoms (-1.76 for Veramyst versus -1.26 for placebo; p=0.007).

In this study, the most common drug-related adverse event reported was epistaxis or nosebleed (8% Veramyst 110 mcg; 4% placebo group). The incidence of laboratory abnormalities was low, and ECG and vital sign changes were minor and similar between the two groups.

About Veramyst

Veramyst Nasal Spray is indicated for the treatment of symptoms of seasonal and perennial allergic rhinitis in adults and in children age two years and older.

In a prior 4-week study, patients 12 years of age and older with perennial allergic rhinitis who were treated with Veramyst 110 mcg once daily did not experience statistically significant improvement in ocular symptom scores.

Veramyst is delivered using a device that has a side-actuated "mist release" button that, when pressed, delivers the same amount of medicine every time* in a gentle fine mist.

*Veramyst should not be used after 120 sprays (after initial priming) because consistent dosing cannot be assured even though the bottle may not be completely empty.

Important Information about Veramyst

Side effects include nosebleed or nasal sores. Nasal fungal infection, glaucoma or cataracts may occur. Have regular eye exams. Do not spray in eyes.

For best results use Veramyst once daily. Maximum relief may take several days. Results may vary. To learn more about prescription Veramyst, talk to your doctor.

About Intranasal Corticosteroids

The way intranasal corticosteroids (INSs) work is not fully understood but by acting early and throughout the allergy process, INSs work a on whole range of chemicals that lead to symptoms such as nasal congestion, sneezing and runny or itchy nose. This class of medicine is considered first-line therapy when nasal congestion is the primary symptom of the patient's rhinitis.

About Allergic Rhinitis

Allergic rhinitis (AR), known as nasal allergies, is an inflammatory reaction of the nasal passages to allergens, such as dust mites, animal dander, mold spores, and pollens. One of the most prevalent and chronic diseases in the U.S., nasal allergies affect up to 40 million people annually, including 10 to 30 percent of adults and up to 40 percent of children. Within minutes of exposure to an allergen, immune response cells release inflammatory mediators that lead to inflammation and produce symptoms including nasal congestion, sneezing and runny or itchy nose. Seasonal allergic rhinitis, triggered by pollens, occurs during certain seasons and lasts a few weeks to a few months. Perennial allergic rhinitis, triggered by dust mites, animal dander, and mold, occurs year-round.

About GlaxoSmithKline

GlaxoSmithKline (NYSE: GSK) is one of the world's leading research-based pharmaceutical and healthcare companies. GlaxoSmithKline is committed to improving the quality of human life by enabling people to do more, feel better, and live longer. For company information visit http://www.gsk.com.


'/>"/>
SOURCE GlaxoSmithKline
Copyright©2007 PR Newswire.
All rights reserved

Related medicine technology :

1. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
2. Study Shows Combination Therapy Incorporating AVODART(R) and Tamsulosin Provides Continuous Symptom Improvement Over 2 Years
3. Largest Study to Date Shows Significant Reductions in Risks of Blood Clots and Reintervention With CYPHER(R) Sirolimus-eluting Coronary Stent Compared to Taxus Stent
4. Kosans Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
5. Study Shows Plasma-Derived Human Thrombin Equivalent to Bovine Thrombin in Achieving Hemostasis in Surgery
6. Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure
7. New Data From Large Safety Analysis of MYCAMINE Shows Favorable Clinical Safety Profile
8. Feeling Anxious or Distracted? New Research Shows a Cup of Tea Could Help
9. New Study Shows Once-Monthly Boniva(R) is as Clinically Effective as Once-Weekly Fosamax(R) at Increasing Bone Mineral Density in Postmenopausal Women With Osteoporosis
10. Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
11. Newly Published Phase II Study Shows the Investigational Drug Vandetanib Prolongs Progression-Free Survival in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... One of Australia,s successful biotechnology ... a new biotechnology company, Noxopharm Limited [ABN 50 608 966 123] ... to list on the ASX. Noxopharm is a clinic-ready ... a Phase 1 clinical study later this year. ... the biggest problems facing cancer patients - the ability of cancers ...
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... Antitrust Improvements Act of 1976, as amended ("HSR"), with ... ("Celator"; Nasdaq: CPXX ) expired effective June ... As previously announced on May 31, 2016, Jazz ... under which Jazz Pharmaceuticals has commenced a tender offer ...
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, Inc. ... will take whatever measures required to build a strong ... which is currently listed on the OTC Markets-pink current ... Chairman and CEO, "We are seeing an anomaly in ... understand, not only by the Company, but shareholders and ...
Breaking Medicine Technology:
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are confused ... endometriosis. These women need a treatment plan to not only alleviate symptoms and ... help for preservation of fertility and ultimately achieving a pregnancy. The specialists at ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
Breaking Medicine News(10 mins):