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New Data Shows Prescription Omega-3 Acid Ethyl Esters Reduced the Incidence of Death in Heart Failure Patients
Date:9/4/2008

mortality, compared with the placebo group. The study also demonstrated that patients in the omega-3 acid ethyl esters group had an eight percent relative risk reduction in death or hospital admissions for cardiovascular reasons compared to the placebo group.

GSK acquired the rights to LOVAZA early this year when it completed an acquisition of Reliant Pharmaceuticals Inc. Since then, GSK has committed significant resources to better educate U.S. doctors and patients on LOVAZA's role in treating very high triglycerides.

About The GISSI-HF Trial

The GISSI Heart Failure Project is a multicenter, randomized, double blind, placebo controlled study from 357 cardiology and internal medicine centers in Italy that evaluated patients with symptomatic heart failure. Patients 18 years and older with clinical evidence of heart failure of any cause classified according to the European Society of Cardiology guidelines as New York Heart Association class II-IV were randomized to receive 1g daily omega-3 acid ethyl esters (3,494 patients) or placebo (3,481 patients). Median age of study participants was 67 years and 42 percent of participants were older than 70 years. At study admission, patients were already on optimal therapy for heart failure e.g. 94 percent of patients were on ACE Inhibitors / ARBs, 65 percent on beta blockers and 39 percent on spironolactone. Co-primary endpoints were time to death, and time to death or admission to hospital for cardiovascular reasons.

Patients were followed for a median of 3.9 years. Results from the study showed that long term treatment with omega-3 acid ethyl esters resulted in a nine percent relative risk reduction in all cause mortality; 955 patients in the omega-3 acid ethyl esters group (27%) died, compared with 1014 (29%) in the placebo group. The study also demonstrated that patients in the omega-3 acid ethyl esters group had an eight percent relative risk reduction in death or hospital admissions for cardi
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SOURCE GlaxoSmithKline
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