Navigation Links
New Data Shows Investigational Triple Antihypertensive Combination Therapy Significantly Lowers Blood Pressure in Hard-to-Treat Patients with Hypertension and Diabetes
Date:6/28/2010

to 0.0042) and seated systolic blood pressure (P less than or equal to 0.0003) compared with each dual combination group.(4)

Additionally, in both the ethnicity and BMI subgroups of the study, the triple combination of olmesartan medoxomil / amlodipine / hydrochlorothiazide (40/10/25 mg) resulted in a greater percentage of patients reaching blood pressure goal compared with each dual combination group.(4) The incidence of treatment-emergent events in the BMI and ethnicity subgroup analyses was comparable between groups and adverse events were mild or moderate.(4)

TRINITY Study Design

At total of 2,492 patients with moderate to severe hypertension were enrolled into the Phase 3, multicenter, randomized, double-blind, parallel-group study, which examined the safety and efficacy of the triple combination of olmesartan medoxomil / amlodipine / hydrochlorothiazide (40/10/25 mg).(1,4) Patients were randomized to receive one of three dual combination therapies (n=2,456) or placebo (n=36) for the first two weeks of the study: olmesartan medoxomil (40 mg) / amlodipine (10 mg); olmesartan medoxomil (40 mg) / hydrochlorothiazide (25 mg); or, amlodipine (10 mg) / hydrochlorothiazide (25 mg).(1,4)  After the first two weeks, until week four, the 36 patients on placebo were switched to one of the dual combination therapies.(1,4) At four weeks, a subset of patients from each of the three dual combination groups were switched to the triple combination therapy of olmesartan (40 mg) / amlodipine (10 mg) / hydrochlorothiazide (25 mg) and continued for 12 weeks (n=627).(1,4) The 12 week double-blind treatment period was followed by a 40 week open-label treatment period.(1,4) The 12-week results were presented at the American Society of Hypertension (ASH) annual meeting earlier this year, which found that the blood pressure-lowering and percentage of patients reaching the current
'/>"/>

SOURCE Daiichi Sankyo
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Phase 2 Data for Ultra-Long-Acting Insulin Degludec Shows the Potential to Effectively Lower Blood Sugar, Including When Used Three Times a Week
2. Syndax Pharmaceuticals Entinostat Shows Clinical Promise in Patients with Advanced Hormone Refractory Breast Cancer
3. Highmark Study Shows Integrated Medical and Pharmacy Benefits Lower Costs, Promote Better Health
4. New Report Shows Record Number of Medicines Currently in Development to Treat Diabetes
5. Drug in New Class of Targeted Therapies Shows Early Promise Against Blood-Related Cancers
6. New Study Shows ENJUVIA® Significantly Reduced Sleep Time Awakenings Caused by Hot Flashes in Postmenopausal Women
7. Implanted Sleep Device Shows Promising Early Results
8. Data Shows Ambulance Fees Will Deter Emergency Calls for Help
9. New Study Shows 84 Percent Reduction in Post-Cesarean Section Infections Through Comprehensive Prevention Strategy
10. Novavaxs Seasonal Influenza VLP Vaccine Candidate Shows Positive Results in a Phase II Clinical Trial in Older Adults
11. Study Shows Superior Efficacy for TAXUS(R) Express(R) Stents at One Year Compared to Bare-Metal Stents in Diabetic Patients Experiencing Heart Attack
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... , July 22, 2014 The National ... operate the Center for Space Radiation Research (CSRR) under ... Boerma is an Associate Professor of Pharmaceutical Sciences within ... of Pharmacy Division of Radiation Health. She is located ... will direct a team of investigators working across four ...
(Date:7/22/2014)... Mass. , July 22, 2014  Decision Resources Group ... Canada will remain relatively stagnant at ... despite the fact that percutaneous coronary intervention (PCI) volumes are ... other developed markets, such as the United States ... will be largely driven by the increase in penetration of ...
(Date:7/22/2014)... , July 22, 2014  Decision Resources ... multiple sclerosis (MS) patients currently treated with ... have ever experienced flushing and/or gastrointestinal events ... patients are currently experiencing these side effects, ... effective medical management of such events. In ...
Breaking Medicine Technology:Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 2Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 3The Canadian Interventional Cardiology Device Market Will Remain Relatively Stagnant Through 2022 at Around $80 Million 2The Canadian Interventional Cardiology Device Market Will Remain Relatively Stagnant Through 2022 at Around $80 Million 3Over Half of Audited Multiple Sclerosis Patients Currently Treated with Biogen Idec's Tecfidera Have Experienced Minor Side Effects Although Impact on Use Appears Muted 2Over Half of Audited Multiple Sclerosis Patients Currently Treated with Biogen Idec's Tecfidera Have Experienced Minor Side Effects Although Impact on Use Appears Muted 3
... 2011 /PRNewswire-Asia/ -- After 3 months of customer opinion ... between Shenzhen Wuzhou Changlian International Trading Co. and their ... brand new series of health-care products including digital thermometers, ... blood pressure monitors . The newly arrived ...
... Polar ( www.polarusa.com ), the leader in ... it has been named a " Best Company to Work ... York State Society for Human Resource Management, Inc., the Business ... 22 in the under 250 employees group. The award honors ...
Cached Medicine Technology:Polar USA Named a Best Company to Work for in New York for Second Straight Year 2
(Date:7/22/2014)... (PRWEB) July 22, 2014 United Benefit ... organization, announces that Les McPhearson, an insurance veteran with ... CEO effective immediately and be based in the company's ... "I am delighted that Les chose to accept this ... qualified to address the many challenges facing UBA and ...
(Date:7/22/2014)... A Florida woman has filed a Xarelto ... death of her husband was the result of uncontrollable ... LLP reports. According to her complaint, which was filed ... District of Florida on June 23rd, the decedent began ... hemorrhage the following June. Despite emergency treatment, his doctors ...
(Date:7/22/2014)... Steven Reinberg HealthDay Reporter ... who are obese during pregnancy may be more likely to ... suggests. "We found that, compared with children born from ... obese during pregnancy had up to 20 to 30 percent ... an assistant professor of pediatrics at Children,s Hospital of Pittsburgh. ...
(Date:7/22/2014)... The American Society of Hematology (ASH) will honor ... Medicine, and Robert P. Hebbel, MD, of the University ... Lecture and Prize for their significant research advances in ... Beutler Lecture, named for the late Ernest Beutler, MD, ... than 50 years, is a two-part lectureship that recognizes ...
(Date:7/22/2014)... of the Clean Plate Club you eat pretty much ... A new Cornell University study shows that the average ... his or her plate. "If you put it ... Wansink Ph.D., author of the forthcoming book, Slim by Design, ... Brand Lab. , Wansink and co-author Katherine Abowd Johnson analyzed ...
Breaking Medicine News(10 mins):Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 2Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 3Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 4Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 5Health News:Xarelto Lawsuit Filed by Florida Woman Alleges Uncontrollable Bleeding Led to Husband’s Death, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit Filed by Florida Woman Alleges Uncontrollable Bleeding Led to Husband’s Death, Bernstein Liebhard LLP Reports 3Health News:Obesity During Pregnancy Linked to Raised Asthma Risk in Kids 2Health News:Obesity During Pregnancy Linked to Raised Asthma Risk in Kids 3Health News:Michael DeBaun, M.D., M.P.H., and Robert P. Hebbel, M.D., to present 2014 ASH Beutler Lecture 2Health News:Michael DeBaun, M.D., M.P.H., and Robert P. Hebbel, M.D., to present 2014 ASH Beutler Lecture 3Health News:Michael DeBaun, M.D., M.P.H., and Robert P. Hebbel, M.D., to present 2014 ASH Beutler Lecture 4
... 17 When most people go,out to mow the lawn, ... the last thing they think about is protecting their eyes, ... Eye Injury Prevention Month, and Eye M.D.s across the,country are ... caused by the most ordinary of activities., "More than ...
... from the California Institute of Technology (Caltech) have created ... biological computer--that is capable of taking in and responding ... a time. , In the future, such devices could ... used as sensors to sniff out tumor cells or ...
... candy,Thanksgiving turkey, holiday eggnog, cookies and cake: We,re nearing ... becomes especially,challenging. One group of people faces a different ... For frail elderly with memory,impairment, preventing weight loss, not ... memory-impaired seniors may forget to eat or they,may not ...
... Schering-Plough,Corporation (NYSE: SGP ) today announced the ... Ruurd Stolp, D.V.M., Ph.D., to Raul E. Kohan, ... Health unit. In his role as,senior vice president ... to Fred Hassan, chairman and chief,executive officer., ...
... SalesForce4Hire, LLC ( www.salesforce4hire.com ) announced today the ... a division of a leading Medical Device company ... This initiative is designed to support and enhance ... sales force and takes advantage of SalesForce4Hire’s Beta ...
... blood sugar , , FRIDAY, Oct. 17 (HealthDay News) -- Spices ... a shake of this and a pinch of that could ... herbs and spices and found that many appear to have ... by high blood-sugar levels in the body. , The study ...
Cached Medicine News:Health News:The Most Ordinary Things Can Cause the Most Extraordinary Eye Injuries, Says the Oklahoma Academy of Ophthalmology 2Health News:Caltech engineers build first-ever multi-input 'plug-and-play' synthetic RNA device 2Health News:A Different Kind of Weight Control Issue: Keeping Pounds On, Not Off 2Health News:Schering-Plough Announces Transition of Animal Health Leadership 2Health News: SalesForce4Hire Builds Custom Sales Force for Division of Leading Worldwide Health Care Company 2Health News:Spices, Herbs Boost Health for Diabetics 2
The flexible endoscope was mainly developed for the pure neuroendoscopy. Due to the working channel it is ideal suitable for therapeutic indications e.g. subdural hematomas, cysts or intraventricular...
Bipolar gingivoplasty loop. Individual sterile packs....
... Performance Instrument System. It is the only ... electric power with the unparalleled high performance ... The advanced design of this instrument system ... cooling system, advanced control circuitry, and the ...
... is a high speed pneumatic ... dissection of bone, biometals, bioplastics ... not only provides speed 80,000 ... the control and precision that ...
Medicine Products: