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New Data Shows Investigational Triple Antihypertensive Combination Therapy Significantly Lowers Blood Pressure in Hard-to-Treat Patients with Hypertension and Diabetes
Date:6/28/2010

diabetes cohort compared to the dual combination therapy groups (38.5/21.5 mm Hg versus 28.9 to 31.9/14.7 to 17.8 mm Hg, respectively, p<0.0001).(1) Mean baseline blood pressure for the non-diabetes cohort was 167.4/101.4 mm Hg in the triple combination therapy group compared to 167.3-168.6/101.2-101.6 mm Hg in the dual combination therapy groups.(1)

Publication-Only Abstract on Ethnicity and BMI Subgroup Analysis

Two additional pre-specified subgroup analyses of the TRINITY study by ethnicity (Hispanic/Latino or non-Hispanic/Non-Latino) and body mass index (BMI) category of <30 kg/m2 or greater than or equal to 30 kg/m2 found that the triple combination therapy was similarly more effective than dual regimens, regardless of the ethnicity and BMI of the patient.(4)

It is estimated that hypertension affects 21 percent of Hispanic adults (18 years or older) in the U.S.(5)  Additionally, the majority of patients with high blood pressure are overweight, with the condition being six times more frequent in obese people.(6)

Results for the ethnicity subgroup analysis [Hispanic or Latino (n=369, 14.8 percent) and non-Hispanic or non-Latino (n=2,122)] showed that the olmesartan medoxomil / amlodipine / hydrochlorothiazide (40/10/25 mg) triple combination therapy produced a significantly greater mean reduction in seated diastolic blood pressure (P less than or equal to 0.0236) and a greater reduction in seated systolic blood pressure from baseline to week 12 compared with each dual combination therapy regardless of ethnicity.(4)  Additionally, in both non-obese patients (n=937, BMI of <30 kg/m2) and obese patients (n=1,555, BMI of greater than or equal to 30 kg/m2), the triple combination therapy (40/10/25 mg) resulted in significantly greater LS mean reductions in seated diastolic blood pressure (P less than or equal
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SOURCE Daiichi Sankyo
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