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New Data Shows Investigational Triple Antihypertensive Combination Therapy Significantly Lowers Blood Pressure in Hard-to-Treat Patients with Hypertension and Diabetes
Date:6/28/2010

Approximately 70 percent of people with diabetes have high blood pressure,(3) which puts them at greater risk of developing long-term complications such as cardiovascular and renal disease.(2) In order to achieve recommended blood pressure control of <130/80 mm Hg, the majority of people with diabetes are likely to need to take two or more antihypertensive medications.(2)

About 15.5 percent (387 of 2,492) of the entire patient population of the TRINITY study were hypertensive patients with diabetes, and were thus included in this subgroup analysis.(1) In these patients, the triple combination therapy was well tolerated with most reported adverse events defined as mild or moderate in severity.(1)

"In addition to taking medications to treat high blood pressure, patients with diabetes often need to take several other medications to ensure glucose and cholesterol levels also are within recommended target levels," said Suzanne Oparil, MD, Professor of Medicine and Physiology and Biophysics at the University of Alabama School of Medicine. "Therefore, having a blood pressure-lowering treatment option that combines three medications into one pill will likely help patients take all of their medications as prescribed. Results of this subgroup analysis are important because it shows that this investigational triple combination therapy can help some of the most challenging patients significantly lower their blood pressure."

The triple combination therapy (40/10/25 mg) also demonstrated superior efficacy in the non-diabetes cohort with 68.6 percent of patients achieving goal compared to 39.0 to 52.8 percent in the dual combination therapy groups (P<0.0001).(1) Treatment with the triple combination therapy (40/10/25 mg) also resulted in greater LS mean reductions in systolic and diastolic blood pressure in the non-
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SOURCE Daiichi Sankyo
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