Navigation Links
New Data Shows Breakthrough microRNA-Targeted Therapy Developed Using Santaris Pharma A/S Proprietary LNA Technology Holds Promise as New Treatment for Hepatitis C
Date:12/3/2009

C3649 inhibits miR-122, an important microRNA involved in HCV replication, the HCV is blocked from replicating without the apparent selection of resistant mutants. SPC3649 has other important properties that make it attractive as a therapeutic agent for HCV. The preclinical data show changes in the expression of key genes that may help patients who do not respond to interferon treatment to become responsive.

SPC3649 is the first microRNA-targeted drug to enter human clinical trials and is currently undergoing Phase 1 clinical studies in healthy volunteers. These preclinical data provide even greater impetus to further examine the potential of SPC3649 for treating patients infected with HCV.

"Advancing the first microRNA-targeted therapy, SPC3649, into human clinical trials was certainly a breakthrough in science and we are very encouraged by these preclinical findings demonstrating that SPC3649 has the potential to be an effective treatment for patients infected with the Hepatitis C virus," said Henrik 0rum, PhD, Vice President and Chief Scientific Officer of Santaris Pharma A/S. "In drug discovery and development programs internally and with our partners, we continue to demonstrate that our proprietary LNA Drug Platform is fundamental in developing effective RNA-targeted therapies with high affinity, target specificity and remarkable potency for a range of diseases."

Santaris Pharma A/S has a robust product pipeline based on its proprietary LNA technology including mRNA and microRNA drug discovery and development partnerships and collaborations with Shire (rare genetic disorders), Wyeth, now part of Pfizer, (delivery of lead candidates against up to ten targets), GlaxoSmithKline (four viral disease drug candidates) and Enzon Pharmaceuticals (eight cancer targets successfully delivered).

About Locked Nucleic Acid (LNA) Drug Platform

The Locked Nucleic Acid (LNA) Drug Platform developed b
'/>"/>

SOURCE Santaris Pharma A/S
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
2. Study Shows Combination Therapy Incorporating AVODART(R) and Tamsulosin Provides Continuous Symptom Improvement Over 2 Years
3. Largest Study to Date Shows Significant Reductions in Risks of Blood Clots and Reintervention With CYPHER(R) Sirolimus-eluting Coronary Stent Compared to Taxus Stent
4. Kosans Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
5. Study Shows Plasma-Derived Human Thrombin Equivalent to Bovine Thrombin in Achieving Hemostasis in Surgery
6. Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure
7. New Data From Large Safety Analysis of MYCAMINE Shows Favorable Clinical Safety Profile
8. Feeling Anxious or Distracted? New Research Shows a Cup of Tea Could Help
9. New Study Shows Once-Monthly Boniva(R) is as Clinically Effective as Once-Weekly Fosamax(R) at Increasing Bone Mineral Density in Postmenopausal Women With Osteoporosis
10. Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
11. Newly Published Phase II Study Shows the Investigational Drug Vandetanib Prolongs Progression-Free Survival in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)...  Neurocrine Biosciences, Inc. (NASDAQ: NBIX ) today ... the company as Vice President, Medical Affairs. ... Bill Aurora to the Neurocrine team as our ... President and Chief Executive Officer of Neurocrine Biosciences. "Bill,s ... coupled with his extensive network and influence with psychiatric ...
(Date:5/4/2015)... 4, 2015 Microbrush International, a leading developer, ... dental restorative procedures, today announced the acquisition of ... innovative sectional matrix system used in dental restorative ... the opportunity to add DentiSmart to our growing ... , VP and General Manager of Microbrush. "DentiSmart,s ...
(Date:5/4/2015)... , May 4, 2015  The board of directors of ... a dividend for the second quarter of 2015 of $0.50 ... dividend is payable June 10, 2015, to shareholders of record ... About Eli Lilly and Company Lilly is a global healthcare ... for people around the world. We were founded more than ...
Breaking Medicine Technology:Neurocrine Biosciences, Inc. Announces Appointment of Dr. Bill Aurora as Vice President, Medical Affairs 2Neurocrine Biosciences, Inc. Announces Appointment of Dr. Bill Aurora as Vice President, Medical Affairs 3Microbrush International Announces Acquisition of DentiSmart 2
... Inc.,announced today that a new analysis of pivotal ... Institute at Harbor-UCLA Medical Center,showed that initial treatment ... CIII had similar effects on subjects, regardless of,weight ... were presented today,at the 2008 Endocrine Society Annual ...
... 17 Champions,Biotechnology, Inc. (OTC Bulletin Board: CSBR), ... platforms and tumor specific data to,enhance the value ... begun,preclinical development of the lead Benzoylphenylurea (BPU) sulfur ... compound has shown,promising activity against in vitro and ...
Cached Medicine Technology:New Subset Analysis of AndroGel(R) Data Highlights Efficacy - Regardless of BMI 2New Subset Analysis of AndroGel(R) Data Highlights Efficacy - Regardless of BMI 3New Subset Analysis of AndroGel(R) Data Highlights Efficacy - Regardless of BMI 4Champions Biotechnology Begins Preclinical Development of Its Lead Oncology Drug Candidate 2Champions Biotechnology Begins Preclinical Development of Its Lead Oncology Drug Candidate 3
(Date:5/4/2015)... May 04, 2015 McNeil & ... announces the expansion of coverage for its Emergency ... provider of industry-tailored insurance and proactive risk management to ... we are dedicated to providing our customers with unparalleled ... many evolving needs. We are excited to launch over ...
(Date:5/4/2015)... The Lymphoma Research Foundation (LRF) – the ... lymphoma research and serving the lymphoma community through a ... services – is set to host its annual Ace ... Orange, NJ on June 1, 2015. Since 2010, the ... through LRF. , This year, the Lymphoma Research Foundation ...
(Date:5/4/2015)... 04, 2015 METTLER TOLEDO has ... of Data Integrity in a GXP Regulated Laboratory ... presenter. This webinar will be presented on May ... Data integrity is a critical component of pharmaceutical ... agencies. However, in recent years an increasing number ...
(Date:5/4/2015)... City, OK and Seattle, WA (PRWEB) May 04, 2015 ... announced the formation of a collaboration to facilitate development ... number of ophthalmic disorders that lead to blindness, including ... to the MiDROPS™ formulation platform developed by EyeCRO, which ... the eye via a topical eyedrop. , Under ...
(Date:5/4/2015)... CCL, a top-ranked, global provider of leadership ... other leadership development consultancies. “The CCL Partner Network ... practitioners, expanding our capacity to drive results for individual ... Ryan, CCL President and CEO. , As soon as ... , it will schedule a one-on-one conference with a ...
Breaking Medicine News(10 mins):Health News:Insurance Leader McNeil & Company Expands Coverage for Emergency Services Insurance Program (ESIP), Launches Enhancements to Property and Casualty Insurance Package 2Health News:Insurance Leader McNeil & Company Expands Coverage for Emergency Services Insurance Program (ESIP), Launches Enhancements to Property and Casualty Insurance Package 3Health News:Lymphoma Research Foundation Set to Host Annual Ace Lymphoma Luncheon at Mayfair Farms in West Orange, NJ 2Health News:METTLER TOLEDO Announces Live Webinar on the Importance of Data Integrity in a GXP Regulated Laboratory 2Health News:EyeCRO and NeuMedics Announce Collaboration to Utilize MiDROPS™ Technology for the Development of NM108 2Health News:EyeCRO and NeuMedics Announce Collaboration to Utilize MiDROPS™ Technology for the Development of NM108 3Health News:The Center for Creative Leadership Is Partnering with Lead Star to Create the CCL Partner Network 2
... Report finds youngsters worse off than adults; biggest gaps found ... Kids in the United States aren,t getting the health care ... study shows. , "Children in the U.S. receive only 46 ... they receive worse care than adults in this country, who ...
... tick movement; ... WESTBROOK, Maine, Oct. 10 Ticks have long posed both ... Northeast, but this,fall, new areas of the country may experience ... active during the fall months,and data compiled by the veterinary ...
... 10 Health and nutrition researcher,Kimberly Day tested ... the,market to determine if they are delivering the ... samples of MonaVie, Xango, and Thai-Go to Brunswick,Laboratories, ... The drinks were tested to determine their ORAC ...
... and gene ... therapy -, PHILADELPHIA, ... Katherine A. High,M.D., has been elected to the Institute of Medicine. Dr. ... (Photo: http://www.newscom.com/cgi-bin/prnh/20071010/DCW020 ) The Institute of Medicine (IOM) today ...
... ... Foundation, SAN FRANCISCO, Oct. 10 ... (Oct. 10) the,creation of an innovative national training, awareness and action program,to ... The program will be funded through a $300,000 grant from the ...
... and Organ,Transplantation, WASHINGTON, Oct. 10 The National Kidney,Foundation ... Annual,Kidney Walk on Saturday, October 13, 2007. Registration begins at ... or 1K walk along the scenic C&O,Canal in Georgetown will ... 3222 M Street NW in Washington, DC., The Walk ...
Cached Medicine News:Health News:U.S. Kids Not Getting Needed Health Care 2Health News:U.S. Kids Not Getting Needed Health Care 3Health News:U.S. Kids Not Getting Needed Health Care 4Health News:Migrating Tick Populations Pose Year-Round Disease Threat for People and Pets 2Health News:Migrating Tick Populations Pose Year-Round Disease Threat for People and Pets 3Health News:Children's Hospital Physician Elected to Institute of Medicine 2Health News:World Institute on Disability and American Red Cross Partner to Provide Innovative Training to Better Assist Those With Disabilities 2Health News:World Institute on Disability and American Red Cross Partner to Provide Innovative Training to Better Assist Those With Disabilities 3Health News:World Institute on Disability and American Red Cross Partner to Provide Innovative Training to Better Assist Those With Disabilities 4Health News:The National Kidney Foundation's 6th Annual Kidney Walk to Be Held on Saturday, October 13 2Health News:The National Kidney Foundation's 6th Annual Kidney Walk to Be Held on Saturday, October 13 3
... drugs of abuse tests are highly accurate in ... recommended cut-off as confirmed by GC/MS testing. This ... specific alternative method (such as GC/MS) must be ... Professional judgment should be applied to any drug ...
... Screen Tests are available in 14 configurations ... Designed using Microgenics Antibody Technology, the SureStep ... of care immunoassay targeted to detect MDMA ... and MDEA but no cross-reactivity to any ...
... bottle becomes preservative-free on eye contactits ... and water on eye contact. It ... to moderate dryness or eyes that ... you can have the benefits of ...
... Contact Lens Comfort Drops improve comfort on contact ... contact lenses from your disinfecting system or from ... your finger and place one or two drops ... it in your eyethe lens will go in ...
Medicine Products: